70858-46-7

Basic information

• Product Name: (Z)-N-methyl-9-octadecenamide
• Synonyms: (Z)-N-methyl-9-octadecenamide;9-Octadecenamide, N-methyl-, (9Z)-;N-Methyloleic amide
• CAS NO: 70858-46-7
• Molecular Formula: C₁₉H₃₇NO
• Molecular Weight: 295.50318
• EINECS: 274-945-4
• Mol File: 70858-46-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 439.8 °C at 760 mmHg
• Flash Point: 273.3 °C
• Appearance: /
• Density: 0.864 g/cm³
• Vapor Pressure: 6.2E-08mmHg at 25°C
• Refractive Index: 1.46
• CAS DataBase Reference: (Z)-N-methyl-9-octadecenamide(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-N-methyl-9-octadecenamide(70858-46-7)
• EPA Substance Registry System: (Z)-N-methyl-9-octadecenamide(70858-46-7)

Safety Data

• Hazardous Substances Data: 70858-46-7(Hazardous Substances Data)

Usage

General Description

(Z)-N-methyl-9-octadecenamide is a chemical compound also known as Z9-18:1 MeFA or (Z)-9-octadecenamide, N-methyl-. It is a synthetic fatty acid amide that is commonly used as an emulsifier and surfactant in various personal care products, including lotions, creams, and hair care products. It functions as a skin conditioning agent and helps to improve the texture and stability of cosmetic formulations. Additionally, this compound has been found to have potential anti-inflammatory and analgesic properties, making it a potential ingredient for topical pain relief products. It is important to note that (Z)-N-methyl-9-octadecenamide should be used in accordance with industry and regulatory guidelines to ensure safe and effective use in consumer products.

InChI:InChI=1/C19H37NO/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19(21)20-2/h10-11H,3-9,12-18H2,1-2H3,(H,20,21)/b11-10+

Upstream product

• 112-62-9 Methyl oleate 
• 74-89-5 methylamine 
• 112-80-1 cis-Octadecenoic acid 
• 112-77-6 (Z)-9-octadecenoyl chloride 

Relevant articles and documents

IONIZABLE LIPIDS AND NANOPARTICLE COMPOSITIONS THEREOF

Provided herein are ionizable lipids represented by the Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R1, R2, R3, R4, R5,R6, m, and n are as defined herein. Also provided herein are lipid nanoparticle (LNP) compositions comprising an ionizable lipid of the invention and a capsid-free, non-viral vector (e.g., ceDNA). These LNPs can be used to deliver a capsid-free, non-viral DNA vector to a target site of interest (e.g., cell, tissue, organ, and the like).

COMPOSITIONS AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

Synthesis of fatty N-alkyl amides

Fatty N-alkyl amides are synthesized directly from glycerides (preferably triglycerides) and amines in the absence of a catalyst, and preferably without a solvent. The method provides for products suitable for use without further purification, preferably after separating the glycerol and amide products. The disclosed method is also useful for the synthesis of glycerol from glycerides and ammonia and/or primary amines.