71447-81-9

Basic information

• Product Name: Z-ABU-OSU
• Synonyms: Z-L-AMINOBUTYRIC ACID HYDROXYSUCCINIMIDE ESTER;Z-L-ALPHA-AMINOBUTYRIC ACID N-HYDROXYSUCCINIMIDE ESTER;Z-ABU-OSU;Z-AMINOBUTYRIC ACID-OSU;Z-2-ABU-OSU;Z-L-AMINOBUTYRIC ACID HYDROXYSUCCINIMIDESTER;[(1S)-1-[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl]propyl]carbamic acid phenylmethyl ester;Z-L-α-aminobutyric acid N-hydroxysuccinimide ester
• CAS NO: 71447-81-9
• Molecular Formula: C₁₆H₁₈N₂O₆
• Molecular Weight: 334.32
• Mol File: 71447-81-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.33±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Z-ABU-OSU(CAS DataBase Reference)
• NIST Chemistry Reference: Z-ABU-OSU(71447-81-9)
• EPA Substance Registry System: Z-ABU-OSU(71447-81-9)

Safety Data

• Hazardous Substances Data: 71447-81-9(Hazardous Substances Data)

Usage

General Description

Z-ABU-OSU is a novel crosslinker that contains an N-hydroxysuccinimide (NHS) ester and an amino reactive isocyanate group. This chemical allows for the coupling of amine-containing molecules and proteins through formation of stable amide bonds. The NHS ester group allows for specific labeling of primary amines in proteins and peptides, making it an effective tool for protein-protein and protein-ligand conjugation in biochemical and biophysical studies. Z-ABU-OSU is water soluble and stable in aqueous solutions, making it a versatile and useful crosslinking reagent in various research applications.

Upstream product

• 501-53-1 benzyl chloroformate 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
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Downstream Products

• 185212-65-1 N-benzyloxycarbonyl-(2S)-aminobutyryl-L-proline n-pentylamide 
• 185212-69-5 N-benzyloxycarbonyl-(2S)-aminobutyryl-L-proline-(2S)-methylbutylamide 
• 869307-61-9 N-benzyloxycarbonyl-(2S)-aminobutyryl-L-proline (S)-sec-butylamide 
• 869307-60-8 N-benzyloxycarbonyl-(2S)-aminobutyryl-L-proline (R)-sec-butylamide 
• 185212-64-0 N-benzyloxycarbonyl-(2S)-aminobutyryl-L-proline 
• 247259-10-5 [(S)-1-(2-Oxo-octylcarbamoyl)-propyl]-carbamic acid benzyl ester 

Relevant articles and documents

Structure-Activity Study of 5-Substituted 1-Carbobenzoxy-2-iminohydantoins as Potential Anticonvulsant Agents

On the basis of our previous findings, a series of 5-substituted 2-iminohydantoins has been synthesized and tested for anticonvulsant activity to better understand the SAR of 2-iminohydantoins.Among the compounds tested, (S)-(+)-1-carbobenzoxy-2-iminohydantoin analogs with ethyl (6)-, n-propyl (7a)-, isopropyl (8)-, allyl (9)-, and sec-butyl (11)-substituted groups at the C5 of the iminohydanotin ring provided the best activities against the MES test with ED50 values in the range of 52-74 mg/kg.All of the above compounds except 8 also showed activity against the scMET test with ED50 values in the range of 141-223 mg/kg.All significantly active compounds (1, 6, 7a, 8, 9, and 11) possesed aliphatic hydrocarbon side chains of two- to three-carbon lengths at the C5 position.All of the compounds with no or minimal activity had either shorter or longer side chains.The compounds substituted at the C5 position by aryl groups, arylalkyl groups, or alkyl and arylalkyl groups containing heteroatoms also showed no activity against the MES and scMET tests.The results suggested that the C5 side chain with the correct stereochemistry in 2-iminohydantoins provides optimal anticonvulsant activity when the side chains are aliphatic hydrocarbons with a lenght, ignoring branchingg, of two to three carbons.