7148-74-5Relevant articles and documents
Synthesis of functionalized poly(vinyl acetate) mediated by alkyne-terminated RAFT agents
Góis, Joana. R.,Popov, Anatoliy V.,Guliashvili, Tamaz,Serra, Arménio C.,Coelho, Jorge F. J.
, p. 91225 - 91234 (2015)
Two new xanthates with alkyne functionalities were synthesized for the reversible addition fragmentation chain transfer (RAFT) polymerization of vinyl acetate (VAc). The new RAFT agents were fully characterized by 1H and 13C NMR spectroscopy. Unlike the alkyne terminated RAFT agent (AT-X1) the protected alkyne-terminated RAFT agent (PAT-X1) was able to conduct the RAFT polymerization of VAc with a good control over the molecular weight (MW) and relatively narrow MW distributions (n with conversion as well as the close agreement between Mn,th and Mn,GPC values confirmed the controlled features of the RAFT system. It is worth mentioning that the polymer dispersity remained very low (1H NMR, FTIR-ATR and UV-Vis absorption analysis. The "livingness" of the obtained polymer was confirmed by a successful chain extension experiment. The deprotection of the alkyne functionality in the PVAc, allowed a further copper catalyzed azide-alkyne [3 + 2] dipolar cycloaddition reaction (CuAAC) with an azido terminated-poly(ethylene glycol) (PEG-N3), to afford PVAc-PEG block-copolymers as a proof-of-concept.
Design, synthesis and agricultural evaluation of derivatives of N-Acyl-N-(m-fluoro-benzyl)-6-amino-coumarin
Ding, Yin-hao,Dong, Jing-jing,Feng, Bai-cheng,Hao, Shuang-hong,Jin, Yan,Wei, Yan
supporting information, (2020/08/19)
ABTRACT: This study aims to design and synthesize a series of N-Acyl-N-(m-fluoro- benzyl)-6- amino-coumarins through the principle of active substructure stitching, which are based on the core structure of N-(m-fluoro-benzyl)-6-amino-coumarin. The structures of target compounds e1–e25 have been characterized by 1H NMR, 13C NMR, ESI-MS and elemental analysis. Meanwhile, their agricultural activity have been evaluated in two weeds (Amaranth and Crabgrass) and four widespread noxious pathogens (V.mali, B.cinerea, F.axysporium and C.bacteria). The herbicidal activity results showed that almost all synthetic molecules have a greater impact on the stem system than on the root. Excellent inhibition rates were discovered from compounds e2–e5 and e20–e23 against Amaranth on stems, which were above 58percent(20 mg/L), 68percent(100 mg/L) respectively. Compounds e2 and e21 also exhibited striking inhibition on stems growth of both weeds. Anti-pathogenic activity showed that all the compounds exerted a better inhibitory activity on B.cinerea at 20 ppm compared to control carbendazim. All the heterocyclic substituted compounds (e17–e24, >57percent) made a better influence than the control (54.1percent) at the100 ppm. This research provides promising herbicidal and anti-pathogenic agents that have the better effects and can be potential for further development.
Substituted Pyridazin-3(2 H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists
Deora, Girdhar Singh,Qin, Cheng Xue,Vecchio, Elizabeth A.,Debono, Aaron J.,Priebbenow, Daniel L.,Brady, Ryan M.,Beveridge, Julia,Teguh, Silvia C.,Deo, Minh,May, Lauren T.,Krippner, Guy,Ritchie, Rebecca H.,Baell, Jonathan B.
supporting information, p. 5242 - 5248 (2019/05/28)
Herein we describe the development of a focused series of functionalized pyridazin-3(2H)-one-based formyl peptide receptor (FPR) agonists that demonstrate high potency and biased agonism. The compounds described demonstrated biased activation of prosurvival signaling, ERK1/2 phosphorylation, through diminution of the detrimental FPR1/2-mediated intracellular calcium (Cai2+) mobilization. Compound 50 showed an EC50 of 0.083 μM for phosphorylation of ERK1/2 and an approximate 20-fold bias away from Cai2+ mobilization at the hFPR1.
