717880-58-5

Basic information

• Product Name: 2-broMo-5-iodobenzoic acid Methyl ester
• Synonyms: 2-broMo-5-iodobenzoic acid Methyl ester
• CAS NO: 717880-58-5
• Molecular Formula: C₈H₆BrIO₂
• Molecular Weight: 340.94051
• Mol File: 717880-58-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 328.535 °C at 760 mmHg
• Flash Point: 152.493 °C
• Appearance: /
• Density: 2.059 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-broMo-5-iodobenzoic acid Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-broMo-5-iodobenzoic acid Methyl ester(717880-58-5)
• EPA Substance Registry System: 2-broMo-5-iodobenzoic acid Methyl ester(717880-58-5)

Safety Data

• Hazardous Substances Data: 717880-58-5(Hazardous Substances Data)

Usage

General Description

2-Bromo-5-iodobenzoic acid methyl ester is a chemical compound that belongs to the class of carboxylic acid esters. It is a derivative of benzoic acid, containing a bromine and an iodine atom at the 2nd and 5th positions, respectively. 2-Bromo-5-iodobenzoic acid methyl ester is commonly used in organic synthesis and pharmaceutical research as a building block in the preparation of various compounds, including pharmaceutical intermediates and fine chemicals. Its unique structure and reactivity make it a valuable precursor in the synthesis of complex organic molecules, and it is often utilized as a reagent in the development of new drugs and biologically active compounds.

Upstream product

• 67-56-1 methanol 
• 88-65-3 2-bromobenzoic-acid 
• 6942-37-6 5-amino-2-bromo-benzoic acid methyl ester 
• 25252-00-0 2-bromo-5-iodobenzoic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 1031927-03-3 methyl 5-bromo-2-cyanobenzoate 
• 1256384-09-4 (S)-pyrrolidine-1,2-dicarboxylic acid 2-(2-(4-bromo-3-methoxycarbonylphenyl)-2-oxoethyl) ester 1-tert-butyl ester 
• 1378427-87-2 5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(1-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)ethyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide 
• 1378431-26-5 methyl 5-(1-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)ethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 
• 1378431-24-3 methyl 2-bromo-5-(1-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)ethyl)benzoate 
• 1378431-23-2 methyl 2-bromo-5-(1-bromoethyl)benzoate 

Relevant articles and documents

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The invention relates to a preparation method of a Velpatasvir (GS-5816) intermediate compound which serves as a hepatitis C resisting compound and is as shown in a formula 1, as well as preparation methods of a compound as shown in a formula 3 and a compound as shown in a formula 9. The compound as shown in the formula 3 and the compound as shown in the formula 9 are used for preparing a compound as shown in a formula 2 by nucleophilic substitution under the alkaline conditions; the compound as shown in the formula 2 is used for preparing the compound as shown in the formula 1 by a coupling reaction in the presence of a metal catalyst.

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