720-44-5

Basic information

• Product Name: 4-METHOXYBENZHYDROL
• Synonyms: Benzenemethanol, 4-methoxy-alpha-phenyl-;4-METHOXYPHENYL PHENYL CARBINOL;(4-METHOXY-PHENYL)-PHENYL-METHANOL;4-METHOXYBENZHYDROL;LABOTEST-BB LT00454002;AURORA KA-7054;4-Methoxydiphenylmethanol~4-Methoxyphenyl phenyl carbinol;4-methoxybenzhydryl alcohol
• CAS NO: 720-44-5
• Molecular Formula: C₁₄H₁₄O₂
• Molecular Weight: 214.26
• EINECS: 211-953-9
• Product Categories: Benzhydrols, Benzyl & Special Alcohols
• Mol File: 720-44-5.mol
• Article Data: 302

Chemical Properties

• Melting Point: 67-69°C
• Boiling Point: 363.2 °C at 760 mmHg
• Flash Point: 164.5 °C
• Appearance: /
• Density: 1.121 g/cm³
• Vapor Pressure: 6.55E-06mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.61±0.20(Predicted)
• BRN: 3202445
• CAS DataBase Reference: 4-METHOXYBENZHYDROL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXYBENZHYDROL(720-44-5)
• EPA Substance Registry System: 4-METHOXYBENZHYDROL(720-44-5)

Safety Data

• Safety Statements: 22-24/25
• Hazardous Substances Data: 720-44-5(Hazardous Substances Data)

Usage

General Description

4-Methoxybenzhydrol is a chemical compound with the molecular formula C14H14O2. It is a white to off-white solid with a faint odor, and is used in the production of various pharmaceuticals and organic compounds. 4-Methoxybenzhydrol is known for its antioxidant and antibacterial properties, and is commonly used as an intermediate in the synthesis of other chemicals. It is considered to be relatively stable under normal conditions, and is not known to pose any significant health hazards. Overall, 4-Methoxybenzhydrol is an important chemical compound with a wide range of applications in the pharmaceutical and chemical industries.

InChI:InChI=1/C14H14O2/c1-16-13-9-7-12(8-10-13)14(15)11-5-3-2-4-6-11/h2-10,14-15H,1H3

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 940-00-1 (4-methoxyphenyl)trimethylstannane 
• 100-52-7 benzaldehyde 
• 733-53-9 p-methoxyphenyl(phenyl)iodonium tetrafluoroborate 
• 60-29-7 diethyl ether 
• 6731-11-9 4-methoxybenzhydryl chloride 
• 7732-18-5 water 
• 116664-89-2 (4-methoxyphenyl)-phenylmethyl 4-cyanophenyl ether 
• 834-14-0 p-benzylanizole 
• 108-86-1 bromobenzene 
• 603-33-8 triphenylbismuthane 
• 1078-58-6 diphenylzinc 
• 98-80-6 phenylboronic acid 
• 13139-86-1 4-methoxyphenyl magnesium bromide 

Downstream Products

• 6853-54-9 1-((4-methoxyphenyl)((4-methoxyphenyl)(phenyl)methoxy)methyl)benzene 
• 113650-50-3 (2,4-dimethoxy-phenyl)-(4-methoxy-phenyl)-phenyl-methane 
• 6731-11-9 4-methoxybenzhydryl chloride 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 100-52-7 benzaldehyde 
• 100-17-4 para-methoxynitrobenzene 
• 611-94-9 4-Methoxybenzophenone 
• 720-44-5 (R)-(4-methoxyphenyl)phenylmethanol 
• 32353-14-3 4-methoxybenzhydryl 4-nitrobenzoate 
• 21980-07-4 (4-methoxy-benzhydryl)-malonic acid diethyl ester 
• 94866-76-9 4-methoxybenzhydryl benzoate 
• 59974-80-0 phthalic acid mono-(4-methoxy-benzhydryl ester) 
• 39768-95-1 (4-Fluoro-phenyl)-(4-methoxy-phenyl)-phenyl-methanol 
• 623-12-1 4-chloromethoxybenzene 

Relevant articles and documents

Binaphthyl-prolinol chiral ligands: Design and their application in enantioselective arylation of aromatic aldehydes

Binaphthyl-prolinol ligands were designed and applied in enantioselective arylation of aromatic aldehydes and sequential arylation-lactonization of methyl 2-formylbenzoate. Under optimized conditions, the reactions provided the desired diarylmethanols and 3-aryl phthalides in up to 96% yields with up to 99% ee and up to 89% yields with up to 99% ee, respectively. In particular, essentially optically pure 3-aryl phthalides (over 99% ee) were obtained in large quantities through recrystallization. This journal is

Light-driven MPV-type reduction of aryl ketones/aldehydes to alcohols with isopropanol under mild conditions

Alcohols are versatile structural motifs of pharmaceuticals, agrochemicals and fine chemicals. With respect to green chemistry, the development of more sustainable and cost-efficient processes for converting ketones/aldehydes to alcohols is highly desired. Herein, a direct light-driven strategy for reducing ketones/aldehydes to alcohols using isopropanol as the reducing agent and solvent, in the presence of t-BuOLi, under an air atmosphere at room temperature is developed. This operationally simple light-promoted Meerwein-Ponndorf-Verley (MPV) type reduction can be used to produce various benzylic alcohol derivatives as well as applied to bioactive molecules and PEEK model compounds, demonstrating its application potential.

Tunable System for Electrochemical Reduction of Ketones and Phthalimides

Herein, we report an efficient, tunable system for electrochemical reduction of ketones and phthalimides at room temperature without the need for stoichiometric external reductants. By utilizing NaN3 as the electrolyte and graphite felt as both the cathode and the anode, we were able to selectively reduce the carbonyl groups of the substrates to alcohols, pinacols, or methylene groups by judiciously choosing the solvent and an acidic additive. The reaction conditions were compatible with a diverse array of functional groups, and phthalimides could undergo one-pot reductive cyclization to afford products with indolizidine scaffolds. Mechanistic studies showed that the reactions involved electron, proton, and hydrogen atom transfers. Importantly, an N3/HN3 cycle operated as a hydrogen atom shuttle, which was critical for reduction of the carbonyl groups to methylene groups.