72180-14-4

Basic information

• Product Name: （2s，4s）-1-benzyl-2-methy-4-fluoropyrrolidine-1，2-dicarbo
• Synonyms: （2s，4s）-1-benzyl-2-methy-4-fluoropyrrolidine-1，2-dicarbo;（2s，4s）-1-benzyl-2-methy-4-fluoropyrrolidine-1，2-dicarboxylate;(2S,4S)-1-benzyl 2-methyl 4-fluoropyrrolidine-1,2-dicarboxylate;(2S,4S)-4-fluoro-1,2-Pyrrolidinedicarboxylic acid 2-methyl 1-(phenylmethyl) ester;(2S,4S)-1-(Benzyloxycarbonyl)-2-(methoxycarbonyl)-4-fluoropyrrolidine
• CAS NO: 72180-14-4
• Molecular Formula: C₁₄H₁₆FNO₄
• Molecular Weight: 281.281
• Mol File: 72180-14-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 382.901 °C at 760 mmHg
• Flash Point: 185.372 °C
• Appearance: /
• Density: 1.267 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.538
• Storage Temp.: 2-8°C
• PKA: -5.73±0.60(Predicted)
• CAS DataBase Reference: （2s，4s）-1-benzyl-2-methy-4-fluoropyrrolidine-1，2-dicarbo(CAS DataBase Reference)
• NIST Chemistry Reference: （2s，4s）-1-benzyl-2-methy-4-fluoropyrrolidine-1，2-dicarbo(72180-14-4)
• EPA Substance Registry System: （2s，4s）-1-benzyl-2-methy-4-fluoropyrrolidine-1，2-dicarbo(72180-14-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 72180-14-4(Hazardous Substances Data)

Usage

General Description

The chemical (2s, 4s)-1-benzyl-2-methyl-4-fluoropyrrolidine-1,2-dicarboxylate is a compound with potential pharmaceutical applications. It is a pyrrolidine derivative that contains a fluorine atom and a benzyl group. （2s，4s）-1-benzyl-2-methy-4-fluoropyrrolidine-1，2-dicarbo has the potential to act as a central nervous system stimulant and may have activity as a psychoactive substance. It may also have potential as an anesthetic or analgesic. The specific pharmacological and toxicological properties of (2s, 4s)-1-benzyl-2-methyl-4-fluoropyrrolidine-1,2-dicarboxylate are still being investigated, and further research is needed to fully understand its potential applications.

InChI:InChI=1/C14H16FNO4/c1-19-13(17)12-7-11(15)8-16(12)14(18)20-9-10-5-3-2-4-6-10/h2-6,11-12H,7-9H2,1H3/t11-,12-/m0/s1

Upstream product

• 51-35-4 4R-4-hydroxyproline 
• 501-53-1 benzyl chloroformate 
• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 67-56-1 methanol 
• 1235447-42-3 (2S,4S)-N-Cbz-4-fluoropyrrolidine-2-carbonyl fluoride 
• 64187-48-0 methyl (2S,4R)-1-benzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylate 

Downstream Products

• 185212-86-6 N-benzyloxycarbonyl-(4S)-fluoro-L-proline n-butylamide 
• 1358943-62-0 C₁₃H₁₄FNO₃ 
• 1358946-07-2 C₁₉H₂₂FN₃ 
• 1358945-94-4 C₂₁H₂₆FN₃ 
• 203866-13-1 (2S,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid 
• 203866-16-4 1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate 
• 72204-21-8 N-benzyloxycarbonyl-(4S)-fluoro-L-proline 

Relevant articles and documents

BENZIMIDAZOLE-LINKED INDOLE COMPOUND ACTING AS NOVEL DIVALENT IAP ANTAGONIST

The present invention discloses a benzimidazole-linked indole compound acting as novel divalent IAP antagonist, specifically disclosing the compound shown in fomulas (I) or a pharmaceutically acceptable salt thereof.

Conformationally stabilized catalysts by fluorine insertion: Tool for enantioselectivity improvement

F rigid cats: The power of conformationally stabilized catalysts is demonstrated. By taking appropriate advantage of fluorine insertion (see scheme), purely conformational catalyst design led to a notable improvement in enantioselectivities from around 70% to 91-98.5% ee. The other advantage of this approach is the better understanding of the origin of the stereoselectivity in the given catalytic system. Copyright

NOVEL 4-FLUOROPYRROLIDINE-2-CARBONYL FLUORIDE COMPOUNDS AND THEIR PREPARATIVE METHODS

Novel 4-fluoropyrrolidine-2-carbonyl fluoride compounds as useful fluorinated intermediates are disclosed. Their preparative methods are also disclosed. Useful applications of the 4-fluoropyrrolidine-2-carbonyl fluorides are shown.