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CAS

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721943-77-7

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721943-77-7 Usage

Explanation

The compound consists of 8 carbon atoms, 11 hydrogen atoms, 3 nitrogen atoms, and 1 oxygen atom.
2. Aromatic heterocycle

Explanation

The compound is derived from pyrrole, which is a five-membered aromatic ring containing a nitrogen atom.
3. Amide functional group

Explanation

The compound contains a carbonyl group (C=O) bonded to an amino group (NH2).
4. Methyl group substitution
5. Potential applications

Explanation

1H-Pyrrole-2-carboxamide, 1-amino-3,4-dimethyl-(9CI) has potential uses in organic synthesis, pharmaceutical research, and the development of new compounds with specialized properties and functions.
6. Need for further research

Explanation

More studies are required to fully understand the compound's potential uses and effects.

Check Digit Verification of cas no

The CAS Registry Mumber 721943-77-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,2,1,9,4 and 3 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 721943-77:
(8*7)+(7*2)+(6*1)+(5*9)+(4*4)+(3*3)+(2*7)+(1*7)=167
167 % 10 = 7
So 721943-77-7 is a valid CAS Registry Number.

721943-77-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1H-Pyrrole-2-carboxamide,1-amino-3,4-dimethyl-(9CI)

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:721943-77-7 SDS

721943-77-7Relevant articles and documents

Discovery of the pyrrolo[2,1-f][1,2,4]triazine nucleus as a new kinase inhibitor template

Hunt, John T.,Mitt, Toomas,Borzilleri, Robert,Gullo-Brown, Johnni,Fargnoli, Joseph,Fink, Brian,Han, Wen-Ching,Mortillo, Steven,Vite, Gregory,Wautlet, Barri,Wong, Tai,Yu, Chiang,Zheng, Xiaoping,Bhide, Rajeev

, p. 4054 - 4059 (2004)

The pyrrolo[2,1-f][1,2,4]triazine nucleus was identified as a novel kinase inhibitor template which effectively mimics the well-known quinazoline kinase inhibitor scaffold. Attachment of a 4-((3-chloro-4-fluorophenyl)amino) substituent to the template provided potent biochemical inhibitors of the tyrosine kinase activity of EGFR, as well as inhibition of cellular proliferation of the human colon tumor cell line DiFi. Attachment of a 4-((3-hydroxy-4-methylphenyl)amino) substituent provided potent inhibitors of VEGFR-2 which also showed effects on the VEGF-dependent proliferation of human umbilical vein endothelial cells. Biological activity was maintained with substitution at positions 5 or 6, but not 7, suggesting that the former positions are promising sites for introducing side chains which modulate physicochemical. properties. Preliminary inhibition studies with varying ATP concentrations suggest that, like the quinazoline-based kinase inhibitors, the pyrrolotriazine-based inhibitors bind in the ATP pocket.

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