724453-98-9 Usage
Description
N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea, also known as Diflapolin, is a chemical compound that belongs to the class of urea derivatives. It features a complex molecular structure with a benzothiazol-2-ylmethoxy group attached to a methylphenyl moiety and a 3,4-dichlorophenyl urea group. N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea has been studied for its potential biological activities and applications in various fields.
Uses
Used in Pharmaceutical Industry:
N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea is used as a dual soluble epoxide hydrolase (sEH) and 5-lipoxygenase-activating protein (FLAP) inhibitor. Its dual inhibitory activity makes it a promising candidate for the development of novel therapeutic agents targeting inflammatory and oxidative stress-related diseases.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea serves as a valuable lead compound for the design and synthesis of new analogs with improved pharmacological properties. Structure-activity relationship studies on Diflapolin and its analogs can provide insights into the molecular mechanisms underlying their biological activities and guide the development of more effective and selective inhibitors.
Used in Drug Discovery:
N-[4-(1,3-benzothiazol-2-ylmethoxy)-2-methylphenyl]-N'-(3,4-dichlorophenyl)urea is utilized in drug discovery efforts to identify potential therapeutic agents that can modulate the activity of sEH and FLAP enzymes. These enzymes play crucial roles in the regulation of inflammatory and immune responses, and their inhibition may offer novel treatment strategies for various diseases, including asthma, arthritis, and neurodegenerative disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 724453-98-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,2,4,4,5 and 3 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 724453-98:
(8*7)+(7*2)+(6*4)+(5*4)+(4*5)+(3*3)+(2*9)+(1*8)=169
169 % 10 = 9
So 724453-98-9 is a valid CAS Registry Number.
724453-98-9Relevant articles and documents
N,N' -DIARYLUREA, N,N' -DIARYLTHIOUREA AND N,N' -DIARYLGUANIDINO COMPOUNDS FOR USE IN TREATMENT AND PREVENTION OF INFLAMMATORY DISEASE
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, (2018/05/16)
A compound according to formula I wherein L is CH2-O, CH2-S, CH2-CH2, or CH=CH; R1 and R2 are independently selected out of H, halogen, C1 to C3 alkyl, halogenated C1 to C3 alkyl, C1 to C3 alkyloxy, or halogenated C1 to C3 alkyloxy; Ar is an aryl moiety, preferably phenyl or naphthyl, or a moncyclic- or bicyclic heteroaryl moiety, wherein optionally the aryl or heteroaryl moiety is further substituted; X is O, S, or NR3, wherein R3 is H, C1 to C3 alkyl, halogenated C1 to C3 alkyl, or tert-butyloxycarbonyl; Y is O, S, NR4 or N(R4)R5, wherein R4 and R5 are independently selected out of H or C1 to C3 alkyl; and wherein if Y is O, S, or NR4, then both A are NH, and the punctuated bonds represent a double bond to Y and single bonds to each A; or wherein if Y is N(R4)R5, then one A is N, the other A is NH, and the punctuated bonds represent a double bond to the A being N, a single bond to the A being NH and a single bond to Y; and use of such a compound in treatment or prevention of an inflammatory disease or an inflammation-related disorder.
