102-36-3Relevant articles and documents
COMBINED CARBONYLATION OF NITRO AND AZO COMPOUNDS IN THE SYNTHESIS OF ISOCYANATES
Manov-Yuvenskii, V. I.,Petrovskii, K. B.,Lapidus, A. L.
, p. 2486 - 2489 (1984)
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Kinetics and mechanism of hydrolysis of phenylureas
Salvestrini, Stefano,Di Cerbo, Paola,Capasso, Sante
, p. 1889 - 1893 (2002)
The hydrolysis of phenylureas has been found to be affected by temperature, pH and buffer concentration. Kinetic evidence suggests that the formation of phenylisocyanate, the initial product in the title reaction, occurs via an intermediate zwitterion. Depending on pH and buffer concentrations, the zwitterion can be produced through three parallel routes: at low pH, specific acid-general base catalysis, followed by slow deprotonation of a nitrogen atom by a general base; at high pH, specific basic-general acid catalysis, followed by slow protonation of a N atom by a general acid; at intermediate pH the reaction proceeds through a proton switch promoted by buffers. Bifunctional acid-base buffers such as HCO3-/CO32-, H2PO42- and CH3COOH/CH3COO- are very efficient catalysts. At high buffer concentration, as well as at pH 12, the breakdown of the zwitterion is rate-determining. The results are discussed in relation to recently published papers reporting different pathways.
INFLUENCE OF PYRIDINE AND COMPOUNDS OF VANADIUM, IRON, AND MOLIBDENUM ON THE CARBONYLATION OF AZO AND NITRO COMPOUNDS IN THE PRESENCE OF RhCl3-4H2O
Manov-Yuvenskii, V. I.,Petrovskii, K. B.,Lapidus, A. L.
, p. 546 - 549 (1983)
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Synthesis process of 3,4-dichlorophenyl isocyanate
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Paragraph 0026-0031, (2021/02/13)
The invention discloses a synthesis process of 3,4-dichlorophenyl isocyanate. The synthesis process comprises the following steps: adding 3,4-dichloroaniline and a solvent into a reaction kettle to obtain a 3,4-dichloroaniline solution while adding solid phosgene into the reaction kettle, and heating for dissolving; when the temperature of the reaction kettle reaches 60-100 DEG C, controlling thedripping speed through a DCS to start to dropwise add the 3,4-dichloroaniline solution in the step S1, so that 3,4-dichloroaniline and solid phosgene generate 3,4-dichloroaniline hydrochloride and 3,4-dichlorobenzene methylamino acyl chloride in a solvent medium; removing hydrogen chloride from the 3,4-dichlorobenzene methylamino acyl chloride obtained in S3 to obtain 3,4-dichlorophenyl isocyanate, and after dropwise adding is finished, carrying out reflux heat preservation for 1-3 h; and removing the acid-containing solvent at normal pressure, recycling, transferring the concentrated solutionto a rectifying still, and rectifying to obtain the product 3,4-dichlorophenyl isocyanate. According to the invention, green chemicals are used as production raw materials, so that potential safety hazards caused by phosgene leakage are reduced; and common chemical solid phosgene is adopted to replace virulent phosgene to serve as an acylation reagent, and a green degradable ester solvent is adopted as a reaction medium.
Disrupting the Conserved Salt Bridge in the Trimerization of Influenza A Nucleoprotein
Woodring, Jennifer L.,Lu, Shao-Hung,Krasnova, Larissa,Wang, Shih-Chi,Chen, Jhih-Bin,Chou, Chiu-Chun,Huang, Yi-Chou,Cheng, Ting-Jen Rachel,Wu, Ying-Ta,Chen, Yu-Hou,Fang, Jim-Min,Tsai, Ming-Daw,Wong, Chi-Huey
supporting information, p. 205 - 215 (2020/01/02)
Antiviral drug resistance in influenza infections has been a major threat to public health. To develop a broad-spectrum inhibitor of influenza to combat the problem of drug resistance, we previously identified the highly conserved E339?R416 salt bridge of the nucleoprotein trimer as a target and compound 1 as an inhibitor disrupting the salt bridge with an EC50 = 2.7 μM against influenza A (A/WSN/1933). We have further modified this compound via a structure-based approach and performed antiviral activity screening to identify compounds 29 and 30 with EC50 values of 110 and 120 nM, respectively, and without measurable host cell cytotoxicity. Compared to the clinically used neuraminidase inhibitors, these two compounds showed better activity profiles against drug-resistant influenza A strains, as well as influenza B, and improved survival of influenza-infected mice.