724770-74-5

Basic information

• Product Name: 6-Bromo-2-ethylaminopyridine,HCl
• Synonyms: 6-Bromo-2-ethylaminopyridine,HCl;(6-BroMo-pyridin-2-yl)-ethyl-aMine hydrochloride;6-Bromo-N-ethylpyridin-2-amine hydrochloride;N-(6-Bromopyridin-2-yl)ethylamine;6-BroMo-2-ethylaMinopyridine
• CAS NO: 724770-74-5
• Molecular Formula: C7H9BrN2.ClH
• Molecular Weight: 237.527
• Mol File: 724770-74-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 283℃
• Flash Point: 125℃
• Appearance: /
• Density: 1.491
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 6-Bromo-2-ethylaminopyridine,HCl(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-2-ethylaminopyridine,HCl(724770-74-5)
• EPA Substance Registry System: 6-Bromo-2-ethylaminopyridine,HCl(724770-74-5)

Safety Data

• Hazardous Substances Data: 724770-74-5(Hazardous Substances Data)

Usage

General Description

6-Bromo-2-ethylaminopyridine, HCl is a chemical compound with the molecular formula C7H10BrN2·HCl. 6-Bromo-2-ethylaminopyridine,HCl is a derivative of pyridine, containing a bromine atom and an ethylamine group. The presence of the hydrochloride salt (HCl) indicates that it is a salt form of the compound. 6-Bromo-2-ethylaminopyridine,HCl is used in organic synthesis as a reagent in the preparation of various pharmaceuticals and fine chemicals. It is known for its role as a building block in the synthesis of various biologically active molecules and pharmaceutical products. Additionally, the bromine substitution on the pyridine ring can impart unique properties that make it useful in a variety of chemical reactions and applications.

Upstream product

• 626-05-1 2,6-Dibromopyridine 
• 75-04-7 ethylamine 

Relevant articles and documents

Diarylureas as allosteric modulators of the cannabinoid CB1 receptor: Structure-activity relationship studies on 1-(4-chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1)

The recent discovery of allosteric modulators of the CB1 receptor including PSNCBAM-1 (4) has generated significant interest in CB1 receptor allosteric modulation. Here in the first SAR study on 4, we have designed and synthesized a series of analogs focusing on modifications at two positions. Pharmacological evaluation in calcium mobilization and binding assays revealed the importance of alkyl substitution at the 2-aminopyridine moiety and electron deficient aromatic groups at the 4-chlorophenyl position for activity at the CB1 receptor, resulting in several analogs with comparable potency to 4. These compounds increased the specific binding of [3H]CP55,940, in agreement with previous reports. Importantly, 4 and two analogs dose-dependently reduced the Emaxof the agonist curve in the CB1 calcium mobilization assays, confirming their negative allosteric modulator characteristics. Given the side effects associated with CB1 receptor orthosteric antagonists, negative allosteric modulators provide an alternative approach to modulate the pharmacologically important CB1 receptor.