7250-94-4Relevant articles and documents
Thermal and bromide ion-catalyzed rearrangement of benzofuran dioxetanes to 1-oxaspiro[2.5]octa-5,7-dien-4-ones
Adam, Waldemar,Ahrweiler, Michael,Reinhard, Dirk
, p. 6713 - 6718 (1994)
The reaction of the tetrasubstituted benzofuran dioxetanes 2 with various nucleophiles, e.g. Br-, Cl-, I-, and HN(i-Pr)2, was investigated and the unprecedented bromide ion-catalyzed rearrangement to the hithert
Medicinal composition for combination of paclitaxel and fluorene STAT3 inhibitor
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Paragraph 0045-0048, (2019/02/04)
The invention belongs to the field of pharmaceutical chemistry, and relates to a medicinal composition for combination of paclitaxel and fluorene STAT3 inhibitors. The medicinal composition comprisesan active ingredient consisting of paclitaxel and a STAT3 inhibitor represented by formula (I), and a pharmaceutically acceptable adjuvant, wherein the mass ratio of the paclitaxel to the STAT3 inhibitor represented by formula (I) in the active ingredient is (0.27 to 0.39): 1. The compound has an effect on having persistently activated STAT3 activity MDA-MB-468 cell, DU-145 cells had good inhibitory effect.
STAT3 inhibitors and application thereof
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Paragraph 0037-0040, (2019/01/20)
The invention belongs to the field of medical chemistry, relates to STAT3 inhibitors and an application thereof and particularly relates to compounds for inhibiting the signal transduction and transcription activator-3, a pharmaceutical composition containing the compound and a use of the compounds or the pharmaceutical composition as cancer treatment drugs. The compounds can well inhibit MDA-MB-468 cells and DU-145 cells with sustained STAT3 activity.
