73220-32-3 Usage
Description
(E)-1-(5-chloro-2-hydroxyphenyl)-3-(diMethylaMino)prop-2-en-1-one, also known as clomifene, is a synthetic nonsteroidal compound that functions as a selective estrogen receptor modulator (SERM). It exhibits antiestrogenic properties by inhibiting the effects of estrogen, particularly in breast tissue. Clomifene is recognized for its role in the medical field, particularly in addressing infertility issues in both women and men.
Uses
Used in Fertility Treatment:
Clomifene is utilized as a fertility treatment agent for women, as it stimulates ovulation by promoting the release of hormones crucial for the maturation and release of eggs from the ovaries. This application aids in overcoming infertility challenges by enhancing the chances of conception.
Used in Male Infertility Treatment:
In the medical field, clomifene is also used to address male infertility. It assists in improving sperm production and quality, thereby increasing the likelihood of successful conception.
Used in Hormonal Imbalance Management:
Clomifene is prescribed off-label for managing conditions like hypogonadism, where the body does not produce enough sex hormones. By modulating estrogen levels, it helps in restoring hormonal balance and alleviating symptoms associated with hormonal imbalances.
Used in Cancer Treatment:
Although not explicitly mentioned in the provided materials, clomifene has been studied for its potential use in treating certain types of male breast cancer. It may be utilized as a therapeutic agent in cancer treatment by targeting estrogen receptor-positive tumors and hindering their growth.
Used in Pharmaceutical Industry:
Clomifene is a vital component in the pharmaceutical industry for developing drugs aimed at treating infertility and other hormone-related conditions. Its unique ability to act as a selective estrogen receptor modulator makes it a key compound in formulating medications for various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 73220-32-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,2,2 and 0 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 73220-32:
(7*7)+(6*3)+(5*2)+(4*2)+(3*0)+(2*3)+(1*2)=93
93 % 10 = 3
So 73220-32-3 is a valid CAS Registry Number.
73220-32-3Relevant articles and documents
Visible Light-Promoted Selenylation/Cyclization of Enaminones toward the Formation of 3-Selanyl-4H-Chromen-4-Ones
Liu, Hao-Yang,Zhang, Jia-Rong,Huang, Guo-Bao,Zhou, Yi-Huan,Chen, Yan-Yan,Xu, Yan-Li
supporting information, p. 1656 - 1661 (2021/02/12)
A simple and efficient visible-light-promoted selenylation/cyclization of enaminones have been realized for the practical synthesis of 3-selanyl-4H-chromen-4-ones. This reaction is performed in the mild conditions, no transition metal catalyst or photocatalysts and no additional oxidants are required. In addition, the 3-selanyl-4H-chromen-4-ones could be easily converted to selanyl-functionalized pyrimidines by reacting with benzamidine substrates. (Figure presented.).
T3P mediated domino C(sp2)-H sulfenylation/annulation of enaminones and methylsulfinyls for the synthesis of chromone thioether derivatives
Balakrishna,Gudipati, Ramakrishna,Kandula, Venu,Yennam, Satyanarayana,Uma Devi,Behera, Manoranjan
supporting information, p. 2458 - 2463 (2019/02/14)
A new regioselective method for the synthesis of 3-(methylthio)-4H-chromen-4-one and 3-(phenylthio)-4H-chromen-4-one derivatives has been developed. The reaction between o-hydroxy-phenyl-functionalized enaminones and methylsulfinyl derivatives using T3P gave good yields of chromone thioether derivatives. The reaction proceeds via domino chromone ring construction and C(sp2)-H bond sulfenylation under transition-metal-free conditions.
Iron-Catalyzed Regioselective Decarboxylative Alkylation of Coumarins and Chromones with Alkyl Diacyl Peroxides
Jin, Can,Sun, Bin,Xu, Tengwei,Yan, Zhiyang,Zhang, Xun
supporting information, p. 1585 - 1591 (2019/08/07)
A facile iron-catalyzed decarboxylative radical coupling of alkyl diacyl peroxides with coumarins or chromones has been developed, affording a highly efficient approach to synthesize a variety of α-alkylated coumarins and β-alkylated chromones. The reaction proceeded smoothly without adding any ligand or additive and provided the corresponding products containing a wide scope of functional groups in moderate to excellent yields. This protocol was highlighted by its high regioselectivity, readily available starting materials, and operational simplicity.
