7360-23-8

Basic information

• Product Name: Z-PRO-PRO-OH
• Synonyms: Z-PRO-PRO-OH;Z-PROLYL-L-PROLINE;Z-L-PROLYL-L-PROLINE;Z-Pro-Pro-OH≥ 97% (HPLC)
• CAS NO: 7360-23-8
• Molecular Formula: C₁₈H₂₂N₂O₅
• Molecular Weight: 346.38
• Mol File: 7360-23-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 584.1°C at 760 mmHg
• Flash Point: 307.1°C
• Appearance: /
• Density: 1.345g/cm³
• Vapor Pressure: 1.74E-14mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: -15°C
• CAS DataBase Reference: Z-PRO-PRO-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Z-PRO-PRO-OH(7360-23-8)
• EPA Substance Registry System: Z-PRO-PRO-OH(7360-23-8)

Safety Data

• Hazardous Substances Data: 7360-23-8(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

InChI:InChI=1/C18H22N2O5/c21-16(19-10-5-9-15(19)17(22)23)14-8-4-11-20(14)18(24)25-12-13-6-2-1-3-7-13/h1-3,6-7,14-15H,4-5,8-12H2,(H,22,23)

Upstream product

• 61350-60-5 (S)-benzyloxycarbonyl-proline acid chloride 
• 147-85-3 L-proline 
• 501-53-1 benzyl chloroformate 
• 17708-83-7 (S)-benzyl 2-((S)-2-(methoxycarbonyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 16652-71-4 benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride 
• 57294-42-5 C₂₅H₂₈N₂O₅ 

Downstream Products

• 1221446-60-1 C₃₅H₅₂N₆O₉ 
• 6735-68-8 N-benzyloxycarbonyl-(2S)-prolyl-(2S)-prolylglycine ethyl ester 
• 117928-94-6 benzyl (S)-N-((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)-1-((S)-1-((2S,3R)-2-amino-3-hydroxybutanoyl)pyrrolidine-2 carbonyl)pyrrolidine-2-carboxamide 
• 80840-74-0 Benzyloxycarbonyl-L-prolyl-L-prolyl-L-histidyl-L-leucyl-L-valyl-L-alanyl-L-asparagyl(β-tert-butylester)-L-prolin 
• 80840-73-9 Benzyloxycarbonyl-L-prolyl-L-prolyl-L-histidinhydrazid-sesquitrifluoracetat 
• 17708-83-7 (S)-benzyl 2-((S)-2-(methoxycarbonyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate 
• 78221-26-8 Benzyloxycarbonyl-L-prolyl-L-prolyl-L-histidin-(tert-butyl-oxycarbonyl)-hydrazid-monoacetat 
• 57281-95-5 (S)-2-[(S)-2-(Benzyloxycarbonylmethyl-carbamoyl)-pyrrolidine-1-carbonyl]-pyrrolidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

PROCESS AND INTERMEDIATES FOR SYNTHESIS OF PEPTIDE COMPOUNDS

Disclosed is a new process and intermediates for preparing dipyrrolidine peptide compounds such as, for example, rapastinel. Advantageously, the process may be industrially scalable and cost-effective and use less toxic reagents and/or solvents. Further, the process may be used to prepare peptide compounds having improved purity.

STUDIES OF BITTER PEPTIDES FROM CASEIN HYDROLYZATE - VII. BITTERNESS OF THE RETRO-BPIa (VAL-ILE-PHE-PRO-PRO-GLY-ARG) AND ITS FRAGMENTS.

To explain the bitter taste exhibited by BPIa (Arg-Gly-Pro-Pro-Phe-Ile-Val) which was isolated from casein hydrolyzate, the authors propose the following requirement: its characteristic spatial structure: the basic moiety in the N-terminal and the hydroph