74220-43-2 Usage
Chemical structure
A synthetic steroid hormone derived from progesterone.
Parent compound
Prednisolone, a corticosteroid with anti-inflammatory and immunosuppressant properties.
Anti-inflammatory effects
Similar to prednisolone, it reduces inflammation by inhibiting the production of inflammatory mediators.
Immunosuppressive effects
Suppresses the immune response, making it useful for treating autoimmune conditions.
Medical uses
Treatment of various inflammatory and autoimmune conditions, such as rheumatoid arthritis, asthma, and allergic reactions.
Administration
Typically administered orally or via injection.
Combination therapy
May be used in combination with other medications to achieve the desired therapeutic effect.
Mechanism of action
Inhibits the production of inflammatory mediators and suppresses the immune response.
Molecular weight
400.5 g/mol
Appearance
White to off-white crystalline powder
Solubility
Soluble in most organic solvents, slightly soluble in water.
Stability
Stable under normal temperature and pressure, should be stored in a cool, dry place, and protected from light and moisture.
Safety precautions
Not to be used in patients with a known hypersensitivity to the drug or its components. Long-term use may result in side effects such as weight gain, fluid retention, and increased risk of infection.
Drug classification
Corticosteroid
Pregnancy and lactation
Category C, should be used during pregnancy and lactation only if the potential benefit justifies the potential risk to the fetus or infant.
Drug interactions
May interact with other medications, including other corticosteroids, immunosuppressants, and live vaccines.
Side effects
Common side effects include fluid retention, increased appetite, weight gain, and mood changes. More serious side effects may include adrenal suppression, osteoporosis, and increased risk of infection.
Check Digit Verification of cas no
The CAS Registry Mumber 74220-43-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,2,2 and 0 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 74220-43:
(7*7)+(6*4)+(5*2)+(4*2)+(3*0)+(2*4)+(1*3)=102
102 % 10 = 2
So 74220-43-2 is a valid CAS Registry Number.
74220-43-2Relevant articles and documents
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Bernstein et al.
, p. 1696,1699 (1959)
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Preparation process of halcinonide intermediate
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Paragraph 0008; 0009, (2017/07/19)
The invention provides a prepration process of a halcinonide intermediate. The preparation process comprises the steps: taking a hydrofluoric acid-acetone mixed solvent as a solvent, slowly adding an intermediate N-3 at subzero 40 DEG C to subzero 30 DEG C, carrying out reaction for 4 to 8 hours after material feeding is completed, enabling the temperature to return to subzero 5 DEG C to 0 DEG C, continuously carrying out reaction for 10 to 30 min, slowly adding reaction fluid into a potassium carbonate solution after the reaction is completed, adjusting the PH value to 7.0 to 7.5, filtering and discharging a product, and drying the product to obtain the halcinonide intermediate with the structure as shown in formula N-5. According to the preparation process, a one-pot method is adopted for production, so that the production steps are effectively simplified, and the production period is shortened; the preparation process is more environment-friendly.
