7424-91-1

Basic information

• Product Name: METHYL 3,3-DIMETHOXYPROPIONATE
• Synonyms: METHYL FORMYLACETATE DIMETHYLACETAL;METHYL 3,3-DIMETHOXYPROPIONATE;DMPM;3,3-DIMETHOXYPROPIONIC ACID METHYL ESTER;Methyl 3,3-dimethoxypropanoate;Propanoic acid, 3,3-dimethoxy-, methyl ester;malonaldehydic acid dimethyl acetal methyl ester;3,3-DIMETHOXYPROPIONIC ACID METHYL ESTER 95+%
• CAS NO: 7424-91-1
• Molecular Formula: C₆H₁₂O₄
• Molecular Weight: 148.15708
• EINECS: 231-055-0
• Product Categories: C6 to C7;Carbonyl Compounds;Esters
• Mol File: 7424-91-1.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 77 °C20 mm Hg(lit.)
• Flash Point: 150 °F
• Appearance: Clear colorless/Liquid
• Density: 1.045 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.971mmHg at 25°C
• Refractive Index: n20/D 1.41(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• BRN: 1561517
• CAS DataBase Reference: METHYL 3,3-DIMETHOXYPROPIONATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3,3-DIMETHOXYPROPIONATE(7424-91-1)
• EPA Substance Registry System: METHYL 3,3-DIMETHOXYPROPIONATE(7424-91-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-24/25
• WGK Germany: 3
• Hazardous Substances Data: 7424-91-1(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless liquid

Uses

Methyl β,β-Dimethoxypropionate is used as a reactant in the preparation of tetrahydro-β-carboline derivatives as antitumor growth and metastasis agents.

Synthesis Reference(s)

The Journal of Organic Chemistry, 50, p. 4157, 1985 DOI: 10.1021/jo00221a038

General Description

Methyl 3,3-dimethoxypropionate was used in the synthesis of 3-indolyl α,β-unsaturated carbonyl compounds.

InChI:InChI=1/C6H12O4/c1-8-5(7)4-6(9-2)10-3/h6H,4H2,1-3H3

Synthetic route

methanol (67-56-1) + (E)-β-methoxycarbonylvinyl phenyl sulphone (1865-13-0) → methyl 3,3-dimethoxypropionate (7424-91-1)

Conditions	Yield
With sodium for 0.25h;	100%

methanol (67-56-1) + acrylic acid methyl ester (292638-85-8) → methyl 3,3-dimethoxypropionate (7424-91-1)

Conditions	Yield
With methanesulfonic acid; Pd(OAc)2 on carbon; Pd(OAc)2 on carbon - molybdovanadophosphate; oxygen at 50℃; under 760.051 Torr; for 8h; Oxidation; Addition;	95%
With N,N,N,N,N,N-hexamethylphosphoric triamide; oxygen; copper(l) chloride; dichloro bis(acetonitrile) palladium(II) In 1,2-dimethoxyethane at 50℃; for 5.5h; Product distribution; absence of hexamethylphosphoric triamide, other additives;	92%
With N,N,N,N,N,N-hexamethylphosphoric triamide; oxygen; copper(l) chloride; dichloro bis(acetonitrile) palladium(II) In 1,2-dimethoxyethane at 50℃; for 5.5h;	92%

1,1,1-trichloro-4-methoxy-3-buten-2-one + methanol (67-56-1) → methyl 3,3-dimethoxypropionate (7424-91-1)

Conditions	Yield
With potassium hydride at 10 - 50℃; for 12h; Concentration; Temperature;	93.5%
With potassium carbonate at 0 - 30℃; for 12h; Reagent/catalyst;	81%
With potassium carbonate at 20℃; for 10.5h; Cooling with ice;

trimethyl trans-3-methoxyorthoacrylate (167386-80-3) + trimethyl orthoformate (149-73-5) → methyl 3,3-dimethoxypropionate (7424-91-1)

Conditions	Yield
With toluene-4-sulfonic acid at 100℃; for 2h;	91%

3-(Acetyl-isopropyl-amino)-3-methoxy-propionic acid methyl ester (98014-02-9) → methyl 3,3-dimethoxypropionate (7424-91-1)

Conditions	Yield
With toluene-4-sulfonic acid In methanol for 2.5h; Heating;	90%

methanol (67-56-1) + (E)-1,1,1-trichloro-4-methoxybut-3-en-2-one (116140-91-1) → methyl 3,3-dimethoxypropionate (7424-91-1)

Conditions	Yield
With potassium carbonate for 10h; Ambient temperature;	80%

methanol (67-56-1) + propynoic acid methyl ester (922-67-8) → methyl 3,3-dimethoxypropionate (7424-91-1) + methyl (Z)-β-methoxyacrylate (5739-81-1)

Conditions	Yield
With silver trifluoromethanesulfonate at 70℃; for 20h;	A 4% B 78%

methanol (67-56-1) + propynoic acid methyl ester (922-67-8) → methyl 3,3-dimethoxypropionate (7424-91-1)

Conditions	Yield
With tributylphosphine In methanol at 20℃; for 168h;	71%

methanol (67-56-1) + cyclohexa-1,4-diene (1165952-92-0) → methyl 3,3-dimethoxypropionate (7424-91-1) + malonaldehydebis(dimethylacetal) (102-52-3) + malonic acid dimethyl ester (108-59-8)

Conditions	Yield
With hydrogenchloride; ozone -40 deg C, then ca. 30 min reflux; Yields of byproduct given;	A 60% B n/a C n/a
With hydrogenchloride; ozone at -40℃; -40 deg C, then ca. 30 min reflux; Yield given;	A 60% B n/a C n/a
With hydrogenchloride; ozone at -40℃; Product distribution;	A 60% B n/a C n/a

methyl crotonate (623-43-8, 4358-59-2, 18707-60-3, 130981-57-6) + 3-mercapto-2-butanone (40789-98-8) → methyl 3,3-dimethoxypropionate (7424-91-1) + methyl 4,5-dimethylthiophene-3-carboxylate (14559-13-8)

Conditions	Yield
Stage #1: methyl crotonate; 3-mercapto-2-butanone With sodium methylate In toluene at 15 - 30℃; Industrial scale; Stage #2: With hydrogenchloride In water; toluene Industrial scale;	A n/a B 29.8%

3,3-dimethoxypropionimidate hydrochloride → methyl 3,3-dimethoxypropionate (7424-91-1)

Conditions	Yield
With methanol In hexane for 72h; Ambient temperature;	18%

methanol (67-56-1) + levulinic acid methyl ester (624-45-3) → methyl 3,3-dimethoxypropionate (7424-91-1) + acetic acid methyl ester (79-20-9) + methyl 3-methoxypropionate (3852-09-3) + malonic acid dimethyl ester (108-59-8) + Dimethyl succinate (106-65-0)

Conditions	Yield
With dihydrogen peroxide; toluene-4-sulfonic acid In water at 80℃; for 6h; Reagent/catalyst; Solvent; Baeyer-Villiger Ketone Oxidation; Overall yield = 22 %;	A 13% B n/a C n/a D 8% E n/a

methanol (67-56-1) + 3-oxo-propionic acid ethyl ester (34780-29-5) → methyl 3,3-dimethoxypropionate (7424-91-1)

Conditions	Yield
With hydrogenchloride at -5℃;

sodium methylate (124-41-4) + carbonic acid dimethyl ester (616-38-6) + acetylene (74-86-2) → methyl 3,3-dimethoxypropionate (7424-91-1)

Conditions	Yield
at 80 - 85℃;

methanol (67-56-1) + methyl cis-2-chloroacrylate (3510-44-9) → methyl 3,3-dimethoxypropionate (7424-91-1)

Conditions	Yield
With potassium methanolate

methyl 3-methoxyprop-2-enoate (34846-90-7) + sodium methylate (124-41-4) → methyl 3,3-dimethoxypropionate (7424-91-1)

Conditions	Yield
With N-Phenyl-2-naphthylamine

sodium methylate (124-41-4) + propynoic acid methyl ester (922-67-8) → methyl 3,3-dimethoxypropionate (7424-91-1)

methanol (67-56-1) + 1,1,5,5-tetramethoxy-pent-2-ene (1116-86-5) → methyl 3,3-dimethoxypropionate (7424-91-1) + 1,2-dimethoxy 1,2-dimethoxy-ethane (2517-44-4) + Methyl dimethoxyacetate (89-91-8)

Conditions	Yield
With hydrogenchloride; ozone 1.) -40 deg C, 2.) reflux, 1 h; Yield given. Multistep reaction;
With hydrogenchloride; reflux; ozone

methanol (67-56-1) + (E)-3-hexene-1,6-dioic acid (29311-53-3) → methyl 3,3-dimethoxypropionate (7424-91-1)

Conditions	Yield
Yield given. Multistep reaction;

methanol (67-56-1) + dimethyl (2E)-pent-2-enedioate (41527-39-3) → Dimethyl oxalate (553-90-2) + methyl 3,3-dimethoxypropionate (7424-91-1) + Methyl dimethoxyacetate (89-91-8) + malonic acid dimethyl ester (108-59-8)

Conditions	Yield
With hydrogenchloride; ozone 1.) -40 deg C, 2.) reflux, 1 h; Yield given. Multistep reaction;
With hydrogenchloride; reflux; ozone

methanol (67-56-1) + dimethyl trans-3-hexene-1,6-dioate (25126-93-6) → methyl 3,3-dimethoxypropionate (7424-91-1) + malonic acid dimethyl ester (108-59-8)

Conditions	Yield
With hydrogenchloride; ozone 1.) -40 deg C, 2.) reflux, 1 h; Yield given. Multistep reaction;
With hydrogenchloride; reflux; ozone

methanol (67-56-1) + Methyl linoleate (112-63-0) → methyl 3,3-dimethoxypropionate (7424-91-1) + 1,1-dimethoxyhexane (1599-47-9) + Dimethyl azelate (1732-10-1) + 9,9-bis(methoxy)nonanoic acid methyl ester (1599-48-0)

Conditions	Yield
With hydrogenchloride; ozone 1.) 0 deg C, 2.) reflux, ca. 30 min; Yield given. Multistep reaction. Further byproducts given;
With hydrogenchloride; ozone 1.) 0 deg C, 2.) reflux, ca. 30 min; Multistep reaction. Further byproducts given;

methanol (67-56-1) + methyl linolenate (301-00-8) → methyl 3,3-dimethoxypropionate (7424-91-1) + dimethoxypropane (4744-10-9) + Dimethyl azelate (1732-10-1) + 9,9-bis(methoxy)nonanoic acid methyl ester (1599-48-0)

Conditions	Yield
With hydrogenchloride; ozone 1.) 0 deg C, 2.) reflux, ca. 30 min; Yield given. Multistep reaction. Further byproducts given;
With hydrogenchloride; ozone 1.) 0 deg C, 2.) reflux, ca. 30 min; Multistep reaction. Further byproducts given;

methanol (67-56-1) + cyclohexa-1,4-diene (1165952-92-0) → methyl 3,3-dimethoxypropionate (7424-91-1) + (Z)-3-hexenedioic acid dimethyl ester (70354-00-6) + 1,1,3,6,6-Pentamethoxyhexan (123331-74-8) + 4,6,6-Trimethoxyhexansaeure-methylester (123331-76-0) + (Z)-1,1,6,6-Tetramethoxy-3-hexen (123331-77-1) + (Z)-6,6-Dimethoxy-3-hexensaeure-methylester (123331-78-2)

Conditions	Yield
With hydrogenchloride; ozone at -40℃; for 0.583333h; Product distribution; further products were isolated;

methanol (67-56-1) + cyclohexa-1,4-diene (1165952-92-0) → methyl 3,3-dimethoxypropionate (7424-91-1) + (Z)-3-hexenedioic acid dimethyl ester (70354-00-6) + 1,1,3,6,6-Pentamethoxyhexan (123331-74-8) + (Z)-6,6-Dimethoxy-3-hexensaeure-methylester (123331-78-2)

Conditions	Yield
With hydrogenchloride; ozone at -40℃; for 0.583333h;

methanol (67-56-1) + cyclohexa-1,4-diene (1165952-92-0) → methyl 3,3-dimethoxypropionate (7424-91-1) + (Z)-3-hexenedioic acid dimethyl ester (70354-00-6) + 4,6,6-Trimethoxyhexansaeure-methylester (123331-76-0) + (Z)-6,6-Dimethoxy-3-hexensaeure-methylester (123331-78-2)

Conditions	Yield
With hydrogenchloride; ozone -40 deg C, then 3 d at room temp.;
With hydrogenchloride; ozone at -40℃; for 0.583333h;

methanol (67-56-1) + cyclohexa-1,4-diene (1165952-92-0) → methyl 3,3-dimethoxypropionate (7424-91-1) + (Z)-3-hexenedioic acid dimethyl ester (70354-00-6) + (Z)-1,1,6,6-Tetramethoxy-3-hexen (123331-77-1) + (Z)-6,6-Dimethoxy-3-hexensaeure-methylester (123331-78-2)

Conditions	Yield
With hydrogenchloride; ozone Yield given. Multistep reaction;
With hydrogenchloride; ozone -40 deg C, then 3 d at room temp.;

methanol (67-56-1) + (Z)-1,1,6,6-Tetramethoxy-3-hexen (123331-77-1) → methyl 3,3-dimethoxypropionate (7424-91-1) + malonaldehydebis(dimethylacetal) (102-52-3)

Conditions	Yield
With hydrogenchloride; ozone 1.) -40 deg C, 2.) reflux, 1 h; Yield given. Multistep reaction;
With hydrogenchloride; reflux; ozone

methanol (67-56-1) + acrylic acid methyl ester (292638-85-8) → methyl 3,3-dimethoxypropionate (7424-91-1) + methyl (2E)-3-methoxy-2-propenoate (5788-17-0) + methyl 3-methoxypropionate (3852-09-3)

Conditions	Yield
With supercritical CO2; oxygen; copper dichloride; palladium dichloride at 40℃; for 12h; Product distribution; various catalysts and temperatures;
With supercritical CO2; oxygen; copper dichloride; palladium dichloride at 40℃; for 12h;	A 91.7 % Chromat. B 1.2 % Chromat. C 2.0 % Chromat.
With supercritical CO2; oxygen; dichloro bis(acetonitrile) palladium(II); copper dichloride at 50℃; for 12h;	A 81.1 % Chromat. B 8.8 % Chromat. C 3.5 % Chromat.
With supercritical CO2; oxygen; copper dichloride; palladium dichloride at 50℃; for 12h;	A 42.9 % Chromat. B 3.1 % Chromat. C 6.6 % Chromat.

sodium methylate (124-41-4) + carbonic acid dimethyl ester (616-38-6) + acetylene (74-86-2) → methyl 3,3-dimethoxypropionate (7424-91-1) + methyl 3-methoxyprop-2-enoate (34846-90-7) + dimethoxysuccinate de methyle (2215-04-5) + methoxymaleic acid dimethyl ester

Conditions	Yield
at 80℃;

methyl 3,3-dimethoxypropionate (7424-91-1) → 3,3-dimethoxypropionic acid (6191-98-6)

Conditions	Yield
With potassium hydroxide In methanol at 20℃; for 1.5h;	100%
With water; sodium hydroxide at 110℃; for 0.5h; Inert atmosphere;	95%
With lithium hydroxide In tetrahydrofuran; methanol; water Inert atmosphere;	95%

methyl 3,3-dimethoxypropionate (7424-91-1) + Methyl formate (107-31-3) → sodium 2-(dimethoxymethyl)-3-methoxy-3-oxoprop-1-en-1-olate

Conditions	Yield
With sodium hydride In 1,2-dimethoxyethane; mineral oil at -5 - 50℃; for 17h;	100%
With sodium hydride In 1,2-dimethoxyethane; mineral oil at 20 - 45℃; Inert atmosphere; Cooling with ice;	83%
With sodium hydride In 1,2-dimethoxyethane at 0 - 50℃; for 20h;	73%

chloraminophenamide (121-30-2) + methyl 3,3-dimethoxypropionate (7424-91-1) → 2H-1,2,4-benzothiadiazine-7-(aminosulfonyl)-6-chloro-3,4-dihydro-1,1-dioxide-3-acetic acid methyl ester

Conditions	Yield
With hydrogenchloride In 1,4-dioxane; water at 40 - 90℃; for 0.5h;	100%

methyl 3,3-dimethoxypropionate (7424-91-1) + 5-fluoro-2-iodoaniline → N-(5-fluoro-2-iodophenyl)-3,3-dimethoxypropanamide

Conditions	Yield
With sodium hexamethyldisilazane In tetrahydrofuran at 0 - 20℃; for 1.5h; Inert atmosphere;	100%

methyl 3,3-dimethoxypropionate (7424-91-1) → 3-hydroxy-1,1-dimethoxy-propane (92403-95-7)

Conditions	Yield
Stage #1: methyl 3,3-dimethoxypropionate With lithium aluminium tetrahydride In diethyl ether at 0℃; for 1h; Stage #2: With water; sodium hydroxide In diethyl ether for 1h;	99%
With lithium aluminium tetrahydride In diethyl ether at 0℃; for 1h;	95%

1,2,3-trimethoxybenzene (621-23-8) + methyl 3,3-dimethoxypropionate (7424-91-1) → (E)-3-(2,4,6-trimethoxy-phenyl)-acrylic acid methyl ester (115130-74-0)

Conditions	Yield
With hydrogenchloride In water; acetic acid at 25℃; for 1h; Product distribution / selectivity;	98%

5-(5-amino-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]-pyrimidin-7-one (147677-00-7) + methyl 3,3-dimethoxypropionate (7424-91-1) → methyl 3-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)anilino]propanoate

Conditions	Yield
With triethylsilane; trifluoroacetic acid In dichloromethane at 20℃; Inert atmosphere;	98%
With triethylsilane; trifluoroacetic acid In dichloromethane at 20℃; Inert atmosphere;	98%

methyl 3,3-dimethoxypropionate (7424-91-1) + 4-methoxyphenylhydrazine hydrochloride (19501-58-7) → methyl 5-methoxy-1H-indole-3-carboxylate (172595-68-5)

Conditions	Yield
With acetic acid at 70℃; for 4.5h;	97%

methyl 3,3-dimethoxypropionate (7424-91-1) + ethylmagnesium bromide (925-90-6) → 1-(2,2-dimethoxyethyl)cyclopropan-1-ol (832142-15-1)

Conditions	Yield
titanium(IV) isopropylate In diethyl ether at 25℃; for 18h; Kulinkovich reaction;	96%
Stage #1: methyl 3,3-dimethoxypropionate With titanium(IV) isopropylate In tetrahydrofuran; diethyl ether at 0℃; for 0.166667h; Stage #2: ethylmagnesium bromide In tetrahydrofuran; diethyl ether at 10 - 25℃; for 0.5h;	89%
With titanium(IV) isopropylate In tetrahydrofuran; diethyl ether at 0 - 20℃; for 8h; Inert atmosphere;

methyl 3,3-dimethoxypropionate (7424-91-1) + 5,7-dfluoro-2-(4-fluorophenyl)-1H-indole → methyl (E)-3-[5,7-dfluoro-2-(4-fluorophenyl)-1H-indol-3-yl]prop-2-enoate

Conditions	Yield
With trifluoroacetic acid In dichloromethane for 4h; Reflux;	96%

methyl 3,3-dimethoxypropionate (7424-91-1) + C25H42O8 → C29H46O10

Conditions	Yield
With toluene-4-sulfonic acid In dichloromethane at 20℃; for 1.5h;	94%

methyl 3,3-dimethoxypropionate (7424-91-1) + 3-(4'-fluorophenyl)-1-(1'-methylethyl)-1H-indole (93957-49-4) → methyl trans-3-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]acrylate

Conditions	Yield
With water; trichlorophosphate In acetic acid at 25℃; for 9h; Product distribution / selectivity;	93%
With water; trichlorophosphate In acetonitrile at 50℃; for 18h;	53 % Chromat.

methyl 3,3-dimethoxypropionate (7424-91-1) + C18H20O4S (1379822-72-6) → (±)-(1α,6β)-3β-methyl-7β-(4-benzenesulfonyloxyphenyl)-2,8-dioxabicyclo[4.4.0]decan-9-one

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at -30℃; for 1h; Inert atmosphere;	93%

methyl 3,3-dimethoxypropionate (7424-91-1) → methyl 3-methoxyprop-2-enoate (34846-90-7)

Conditions	Yield
With toluene-4-sulfonic acid at 160℃; for 7.5h;	91%
methanesulfonic acid at 160℃; for 6h; Product distribution / selectivity;	85%
With potassium hydrogensulfate at 150 - 160℃; for 4h; Reagent/catalyst;	82%

methyl 3,3-dimethoxypropionate (7424-91-1) + Methyl formate (107-31-3) → sodium (1Z)-2-(dimethoxymethyl)-3-methoxy-3-oxoprop-1-en-1-olate

Conditions	Yield
With sodium hydride In 1,2-dimethoxyethane at 0 - 35℃; for 16.5h;	90%
Stage #1: methyl 3,3-dimethoxypropionate With sodium hydride In 1,2-dimethoxyethane; mineral oil at 40 - 50℃; for 0.5h; Stage #2: Methyl formate In 1,2-dimethoxyethane; mineral oil at 0 - 50℃;	61%
Stage #1: methyl 3,3-dimethoxypropionate With sodium hydride In 1,2-dimethoxyethane; mineral oil at 40 - 50℃; for 0.5h; Stage #2: Methyl formate In 1,2-dimethoxyethane; mineral oil at 40 - 50℃; for 2h;	61%

methyl 3,3-dimethoxypropionate (7424-91-1) + 2-bromo-5-fluoroaniline (1003-99-2) → N-(2-bromo-5-fluorophenyl)-3,3-dimethoxypropanamide

Conditions	Yield
With sodium hexamethyldisilazane In tetrahydrofuran at 0 - 15℃; for 18h; Inert atmosphere;	90%
With sodium hexamethyldisilazane In tetrahydrofuran; 2-methyltetrahydrofuran at 0 - 22℃; for 16h;
With sodium hexamethyldisilazane In tetrahydrofuran at 0 - 15℃; for 18h;
With sodium hexamethyldisilazane In tetrahydrofuran at 0 - 15℃; for 18h;
With sodium hexamethyldisilazane In tetrahydrofuran at 0 - 15℃; for 18.1667h;	100 mg

methyl 3,3-dimethoxypropionate (7424-91-1) + 1-aminocarbonyl-3-methyl-4-methoxycarbonyl-1,2-diaza-1,3-diene (63160-41-8) → dimethyl 1-[(aminocarbonyl)amino]-2-methyl-1H-pyrrole-3,4-dicarboxylate

Conditions	Yield
Stage #1: methyl 3,3-dimethoxypropionate With Dowex 50W In water at 20℃; for 24h; Stage #2: 1-aminocarbonyl-3-methyl-4-methoxycarbonyl-1,2-diaza-1,3-diene With Duolite A 102 In water at 20℃; for 10h; Further stages.;	89%

methyl 3,3-dimethoxypropionate (7424-91-1) + C6H5BrN4 → C11H13BrN4O3

Conditions	Yield
With potassium hydride In tetrahydrofuran at 0 - 25℃; for 5.5h; Reagent/catalyst;	88.4%

N-(thiophen-3-yl)acetamide (42602-67-5) + methyl 3,3-dimethoxypropionate (7424-91-1) → (E)-3-(3-Acetylamino-thiophen-2-yl)-acrylic acid methyl ester

Conditions	Yield
With hydrogenchloride In dichloromethane for 2h; Ambient temperature;	88%

methyl 3,3-dimethoxypropionate (7424-91-1)

Conditions	Yield
With hydrogenchloride In 1,4-dioxane at 95℃; for 1h; Inert atmosphere;	88%
With hydrogenchloride In 1,4-dioxane at 95℃; for 1h; Inert atmosphere;	88%

Conditions	Yield
With sodium hydride In tetrahydrofuran at 0 - 25℃; for 5.5h;	87.8%

Conditions	Yield
With toluene-4-sulfonic acid In toluene at 80℃; for 6h;	87%

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 40℃; for 3h;	86%

Conditions	Yield
With sodium In diethyl ether for 48h; Ambient temperature;	85%

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 20℃; for 24h;	85%
With trifluoroacetic acid In dichloromethane at 20℃; for 8h; Inert atmosphere;

Upstream product

• 67-56-1 methanol 
• 34780-29-5 3-oxo-propionic acid ethyl ester 
• 124-41-4 sodium methylate 
• 616-38-6 carbonic acid dimethyl ester 
• 74-86-2 acetylene 
• 34846-90-7 methyl 3-methoxyprop-2-enoate 
• 29311-53-3 (E)-3-hexene-1,6-dioic acid 
• 41527-39-3 dimethyl (2E)-pent-2-enedioate 
• 25126-93-6 dimethyl trans-3-hexene-1,6-dioate 
• 112-63-0 Methyl linoleate 
• 301-00-8 methyl linolenate 
• 1066-26-8 sodium acetylide 
• 624-45-3 levulinic acid methyl ester 
• 591-12-8 5-methyl-2-furanone 

Downstream Products

• 6191-98-6 3,3-dimethoxypropionic acid 
• 14341-29-8 1-(benzylideneamino)uracil 
• 21320-99-0 1-phenyl-2-thioxopyrimidin-4(1H,3H)-one 
• 101080-71-1 1-(4-chlorophenyl)pyrimidine-2,4(1H,3H)-dione 
• 1208-14-6 1-benzyl-2-thioxopyrimidin-4(1H,3H)-one 
• 212571-01-2 methyl thieno[3,2-b]pyridine-6-carboxylate 
• 256951-88-9 4-(3,4-difluorophenyl)-1-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid methyl ester 
• 357428-17-2 (1S,2R)-N-(2-hydroxy-1-methyl-2-phenylethyl)-3,3-dimethoxypropanamide 
• 54755-77-0 N-benzyloxycarbonyl-3-aminopropionic acid methyl ester 
• 195524-04-0 (3R,7R,10R,14S)-7,14-Dimethoxy-3,10-diphenyl-1,8-dioxa-4,11-diaza-cyclotetradecane-5,12-dione 
• 195524-06-2 (3R,7S,10R,14S)-7,14-Dimethoxy-3,10-diphenyl-1,8-dioxa-4,11-diaza-cyclotetradecane-5,12-dione 
• 871476-84-5 C₁₀H₉ClN₂O 
• 115130-74-0 (E)-3-(2,4,6-trimethoxy-phenyl)-acrylic acid methyl ester 
• 911010-89-4 methyl 7-benzyl-4-hydroxy-5,6,7,8-tetrahydro-1,7-naphthyridine-3-carboxylate 

Relevant articles and documents

Green preparation method of uracil

The invention relates to a green preparation method of uracil, which comprises the following steps: proportionally mixing acetate, alkali and a benzene solvent in a reaction bottle to obtain a mixed solution, introducing carbon monoxide, pressurizing to generate aldehyde, adding a hydrogen chloride alcohol solution into the reaction bottle, and carrying out condensation reaction on aldehyde and the hydrogen chloride alcohol solution to obtain acetal, and adding urea into the reaction bottle, reacting acetal with urea to obtain a condensate, adding alkali into the reaction bottle, reacting alkali with the condensate to generate uracil sodium salt, adding acidic water into the reaction bottle, crystallizing, cooling, and filtering to obtain uracil. Carbon monoxide and acetate are innovatively used as raw materials, alkali such as sodium methoxide is used for one-pot catalytic synthesis of uracil, the synthesis method in the whole process is mild in condition, simple in process and high in yield and purity, the purposes of few three wastes and environmental protection are achieved, and the method has a good large-scale application prospect.

Preparation method of methyl 3-methoxyacrylate

The invention relates to a synthetic method of methyl 3-methoxyacrylate. The method is characterized by comprising the following steps that: (1) methyl 3, 3-dimethoxypropionate is synthesized from ketene dimer and trimethyl orthoformate at 25-90 DEG C under the catalytic action of an alkaline substance by taking alcohols as a solvent, and the molar ratio of the ketene dimer to trimethyl orthoformate to the alkaline substance is controlled to be 1: (1.0-5.0): (0.5-5.0); and (2) after the reaction is finished, the methyl 3, 3-dimethoxypropionate is cracked under the action of a catalyst to generate 3-methoxy methyl acrylate, and controlling the molar ratio of the methyl 3, 3-dimethoxypropionate to the catalyst to be 1: (1.0-5.0) and the reaction temperature to be 100-200 DEG C. According tothe method, raw materials are cheap and easy to obtain; the synthesis method is simple to operate; the reaction conditions are mild; requirements on equipment are low; and requirements of industrial large-scale production are met.

Preparation method of 3,3-dialkoxylpropionate

The invention belongs to the technical field of preparation of drug intermediates and in particular relates to a preparation method of 3,3-dialkoxylpropionate. The preparation method comprises the following steps: firstly, taking alkyl vinyl ether and trichloroacetyl chloride as raw materials; reacting under a certain condition to obtain an intermediate product 1,1,1-trichloro-4-alkoxyl-3-butene-2-one; reacting under an alkaline condition to obtain a target product 3,3-dialkoxylpropionate. The preparation method of the 3,3-dialkoxylpropionate, provided by the invention, has the following active effects that one raw material is directly used as a solvent (trichloroacetyl chloride) to react and the recycling and consumption of the solvent in a production process are reduced to a certain extent; after the reaction, an alcohol solvent can be recycled and is used for reacting for the next time, so that the recycling is realized and the scheme meets the requirements of green chemistry; a preparation process is simple, low in energy consumption and low in cost and can be in mass production.