74420-05-6

Basic information

• Product Name: 4-CHLORO-1-METHYL-1H-PYRROLO[2,3-B]PYRIDINE
• Synonyms: 4-CHLORO-1-METHYL-1H-PYRROLO[2,3-B]PYRIDINE;N-Methyl-4-chloro-7-azaindole;4-Chloro-1-methyl-7-azaindole
• CAS NO: 74420-05-6
• Molecular Formula: C₈H₇ClN₂
• Molecular Weight: 166.61
• Product Categories: Azaindoles
• Mol File: 74420-05-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 275℃
• Flash Point: 120℃
• Appearance: /
• Density: 1.30
• Vapor Pressure: 0.009mmHg at 25°C
• Refractive Index: 1.633
• Storage Temp.: 2-8°C
• PKA: 4.49±0.30(Predicted)
• CAS DataBase Reference: 4-CHLORO-1-METHYL-1H-PYRROLO[2,3-B]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-1-METHYL-1H-PYRROLO[2,3-B]PYRIDINE(74420-05-6)
• EPA Substance Registry System: 4-CHLORO-1-METHYL-1H-PYRROLO[2,3-B]PYRIDINE(74420-05-6)

Safety Data

• Hazardous Substances Data: 74420-05-6(Hazardous Substances Data)

Usage

General Description

4-Chloro-1-methyl-1H-pyrrolo[2,3-b]pyridine, also known as PCMPP, is a chemical compound with the molecular formula C8H7ClN2. It is a heterocyclic compound containing a pyrrolopyridine core with a methyl and a chloro substituent. It is primarily used in the pharmaceutical industry as a building block for the synthesis of various drug molecules. PCMPP has potential applications in the development of new drug candidates, particularly in the field of oncology and central nervous system disorders. It is also used as a research chemical in the study of chemical reactions and mechanisms. However, it is important to handle this compound with caution due to its potential hazards and toxicity.

InChI:InChI=1/C8H7ClN2/c1-11-5-3-6-7(9)2-4-10-8(6)11/h2-5H,1H3

Upstream product

• 55052-28-3 4-chloro-7-azaindole 
• 74-88-4 methyl iodide 
• 55052-24-9 1H-Pyrrolo[2,3-b]pyridine-7-oxide 
• 271-63-6 7-Azaindole 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AND METHODS OF USE

The present invention discloses compounds useful in treatment of conditions associated with excessive activity of transforming growth factor beta (TGF-β), particularly type 1 or activin-like kinase 5 (ALK 5). Specifically the present invention discloses compound of formula (I) which exhibit inhibitory activity against ALK 5. Method of treating conditions associated with excessive activity (ALK 5) with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.

Synthesis and biological evaluation of 7-azaindole derivatives, synthetic cytokinin analogues

Cytokinins, N6-substituted adenine derivatives, are plant hormones playing important roles in various processes in plant development. Furthermore, cytokinins and their derivatives are able to control mammalian cell apoptosis and differentiation. The aim of our study was the synthesis of 7-azaindole derivatives as cytokinin analogues with the Hartwig-Buchwald coupling reaction in order to evaluate their biological properties on human myeloblastic leukaemia cells (HL-60 cell line). All these compounds presented a cytotoxic activity on HL-60 cells especially the 4-phenylaminopyrrolo[2,3-b]pyridine and the 4-phenethylaminopyrrolo[2,3-b]pyridine.