74552-49-1

Basic information

• Product Name: Diethyl 2-hydroxy-1-(trimethylsiloxy)-1,2-diphenylethanephosphonate
• Synonyms: Diethyl 2-hydroxy-1-(trimethylsiloxy)-1,2-diphenylethanephosphonate
• CAS NO: 74552-49-1
• Molecular Weight: 422.533
• Mol File: 74552-49-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Diethyl 2-hydroxy-1-(trimethylsiloxy)-1,2-diphenylethanephosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: Diethyl 2-hydroxy-1-(trimethylsiloxy)-1,2-diphenylethanephosphonate(74552-49-1)
• EPA Substance Registry System: Diethyl 2-hydroxy-1-(trimethylsiloxy)-1,2-diphenylethanephosphonate(74552-49-1)

Safety Data

• Hazardous Substances Data: 74552-49-1(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 31675-43-1 diethyl 1-phenyl-1-(trimethylsiloxy)methanephosphonate 

Downstream Products

• 74552-63-9 Diethyl 1,2-dihydroxy-1,2-diphenylethanephosphonate 
• 119-53-9 2-hydroxy-2-phenylacetophenone 

Relevant articles and documents

α-Heterosubstituted Phosphonate Carbanions. 11. Benzoins via an Acyl Anion Equivalent. Novel One-Pot Preparation of Benzofurans via Benzoins Using Hydriodic Acid

Diethyl 1-(trimethylsiloxy)-1-phenylmethanephosphonate carbanion 2 is introduced as a novel acyl anion equivalent.When 2 reacts with aldehydes or ketones, a 1,4 oxygen-oxygen silicon migration with subsequent loss of diethyl lithium phosphite is observed.An efficient method utilizing 2 for the preparation of otherwise difficultly obtainable substituted benzoins is presented.Also a novel one-pot method which offers a facile entry into the 2-phenylbenzofuran ring system from 2 via benzoin intermediates using hydriodic acid was developed.