746639-24-7

Basic information

• Product Name: 4β-iodo-4-O-demethylpodophyllotoxin
• Synonyms: 4β-iodo-4-O-demethylpodophyllotoxin
• CAS NO: 746639-24-7
• Molecular Weight: 510.282
• Mol File: 746639-24-7.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 4β-iodo-4-O-demethylpodophyllotoxin(CAS DataBase Reference)
• NIST Chemistry Reference: 4β-iodo-4-O-demethylpodophyllotoxin(746639-24-7)
• EPA Substance Registry System: 4β-iodo-4-O-demethylpodophyllotoxin(746639-24-7)

Safety Data

• Hazardous Substances Data: 746639-24-7(Hazardous Substances Data)

Upstream product

• 6559-91-7 4'-demethylepipodophyllotoxin 
• 40505-27-9 4-demethylpodophyllotoxin 
• 33419-42-0 etoposide 
• 518-28-5 podofilox 

Downstream Products

• 127882-64-8 4'-O-demethyl-4β-(3''-acetylanilino)-4-desoxypodophyllotoxin 
• 125830-40-2 4'-demethyl-4β-(4-chloroanilino)-4-desoxypodophyllotoxin 
• 1224702-80-0 4'-O-demethyl-4β-(1''-pyrenylamino)-4-desoxypodophyllotoxin 
• 1224702-79-7 4'-O-demethyl-4β-(1''-fluorenylamino)-4-desoxypodophyllotoxin 
• 1224702-81-1 4'-O-demethyl-4β-(1''-chrycenylamino)-4-desoxypodophyllotoxin 
• 1224702-78-6 4'-O-demethyl-4β-(1''-anthrylamino)-4-desoxypodophyllotoxin 
• 1224702-82-2 4'-O-demethyl-4β-[4''-(4''-fluorobenzoyl)anilino]-4-desoxypodophyllotoxin 
• 1224702-83-3 4'-O-demethyl-4β-(4''-{4''-[di(2''-chloroethyl)amino]-benzoyl}anilino)-4-desoxy podophyllotoxin 
• 136794-84-8 4'-O-demethyl-4β-O-(methylbenzyl)-4-desoxypodophyllotoxin 

Relevant articles and documents

Synthesis and biological evaluation of prodrugs for nitroreductase based 4-β-amino-4′-Demethylepipodophyllotoxin as potential anticancer agents

A series of prodrugs for nitroreductase (NTR) based 4-β-amino-4′- Demethylepipodophyllotoxin as potential anticancer agents were synthesized, and their antiproliferative activities in vitro showed compounds 2b (IC50 = 0.77, 0.83 and 1.19 μM) an

4 beta-amino substituted podophyllotoxin derivative and preparation method and application thereof

The invention discloses a 4 beta-amino substituted podophyllotoxin derivative and a preparation method and application thereof. Heteroaromatic compounds such as anthraquinone, quinazoline, quinoline,indole and pyrimidine are introduced into the fourth site of podophyllotoxin or 4'-demethyl podophyllotoxin C-ring as substituent groups respectively so as to obtain the podophyllotoxin derivative shown as a formula (V). In vitro tumor cell activity inhibition experiments indicate that the anti-tumor activity of most compounds shown as the formula (V) is obviously improved compared with the anti-tumor activity of the antineoplastic activity patent medicine ''etoposide''.

Synthesis and Biological evaluation of novel 4β-[(5-substituted)-1,2,3,4-tetrazolyl] podophyllotoxins as anticancer compounds

A series of novel 4β-[(5-substituted)-1,2,3,4-tetrazolyl] podophyllotoxin derivatives were synthesized by employing azide-nitrile click chemistry approach. All the derivatives were evaluated for their cytotoxicity against a panel of four human cancer cell lines and their IC50 values were found to be in the range of 2.4-29.06 μM. The cytotoxicity exhibited by the majority of test compounds were found to comparable and often more effective than doxorubicin and all compounds exhibited higher cytotoxicity on A-549 cell lines. Cell cycle analysis showed that the novel 4β-[(5-substituted)-1,2,3,4-tetrazolyl] podophyllotoxins resulted in cell cycle arrest at G2/M phase and were also found to be the potent inhibitors of tubulin polymerization in vitro.