74702-40-2

Basic information

• Product Name: 4-(Trifluoromethyl)formanilide
• Synonyms: 4-(Trifluoromethyl)formanilide
• CAS NO: 74702-40-2
• Molecular Formula: C₈H₆F₃NO
• Molecular Weight: 189.1345496
• Mol File: 74702-40-2.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 275.3 °C at 760 mmHg
• Flash Point: 120.3 °C
• Appearance: /
• Density: 1.353 g/cm³
• Vapor Pressure: 0.00515mmHg at 25°C
• Refractive Index: 1.499
• CAS DataBase Reference: 4-(Trifluoromethyl)formanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Trifluoromethyl)formanilide(74702-40-2)
• EPA Substance Registry System: 4-(Trifluoromethyl)formanilide(74702-40-2)

Safety Data

• Hazardous Substances Data: 74702-40-2(Hazardous Substances Data)

Usage

General Description

4-(Trifluoromethyl)formanilide is a chemical compound with the molecular formula C8H6F3NO. It is a white to light yellow solid that is commonly used as an intermediate in the production of pharmaceuticals, agrochemicals, and other fine chemicals. 4-(Trifluoromethyl)formanilide is also used in the synthesis of various heterocyclic compounds and is known for its strong analgesic and anti-inflammatory properties. 4-(Trifluoromethyl)formanilide has a wide range of applications in the chemical industry and is considered to be a valuable building block for the synthesis of complex organic molecules. It is important to handle this compound with care as it may be harmful if swallowed, inhaled, or in contact with skin and eyes.

InChI:InChI=1/C8H6F3NO/c9-8(10,11)6-1-3-7(4-2-6)12-5-13/h1-5H,(H,12,13)

Upstream product

• 455-14-1 4-trifluoromethylphenylamine 
• 109-94-4 formic acid ethyl ester 
• 124-38-9 carbon dioxide 
• 64-18-6 formic acid 
• 402-54-0 p-nitrobenzotrifluoride 
• 329-17-9 N,N-dimethyl-4-(trifluoromethyl)aniline 
• 22864-65-9 N-methyl-4-(trifluoromethyl)aniline 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 68-12-2 N,N-dimethyl-formamide 
• 77287-34-4 formamide 
• 298-12-4 Glyoxilic acid 
• 2258-42-6 formyl acetic anhydride 
• 1515782-30-5 C₁₁H₈F₃N₃O 
• 107-31-3 Methyl formate 

Downstream Products

• 7159-99-1 N-(4-Trifluoromethylphenyl)-N',N'-dimethyl-urea 
• 1960-88-9 N,N'-bis-(4-trifluoromethylphenyl)-urea 
• 178607-22-2 1-(4-phenoxyphenyl)-3-(4-(trifluoromethyl)phenyl)urea 
• 23745-49-5 (4-Trifluoromethyl-phenyl)-carbamic acid cyclohexyl ester 
• 25617-39-4 N-(4-(trifluoromethyl)phenyl)cyclohexanecarboxamide 
• 67-56-1 methanol 
• 455-14-1 4-trifluoromethylphenylamine 
• 837404-68-9 4-[3-[(2-chlorophenyl)methyl]-6,7-dihydro-7-oxo-3H-1,2,3-triazole[4,5-d]pyrimidin-5-yl]-N-[4-(trifluoromethyl)phenyl]-1-piperidinecarboxamide 
• 1295558-79-0 5-trifluoromethyl-2-phenylsulfanyl-3-((methoxycarbonyl)(phenylsulfanyl)methyl)-1H-indole 
• 1259117-92-4 tert-butyl 2,2-dibromovinyl(4-(trifluoromethyl)phenyl)carbamate 
• 1259119-29-3 tert-butyl formyl(4-(trifluoromethyl)phenyl)carbamate 
• 74702-21-9 C₆H₄(CF₃)N(CHO)SCFCl₂ 
• 914490-57-6 1-[4-(7-benzyloxy-6-methoxy-quinolin-4-yloxy)-3-fluoro-phenyl]-3-(4-trifluoromethyl-phenyl)-urea 
• 30613-77-5 <4-(Trifluormethyl)phenyl>isocyanid-dichlorid 

Relevant articles and documents

Olefin functionalized IPr.HCl monomer as well as preparation method and application thereof

The invention relates to an olefin functionalized IPr.HCl monomer, a preparation method thereof, a method for preparing an N-heterocyclic carbene functionalized organic polymer (PS-IPr-x) by using the olefin functionalized IPr.HCl monomer, and application of the N-heterocyclic carbene functionalized organic polymer as a heterogeneous catalyst for catalyzing reduction N-formylation of carbon dioxide and amine. A heterogeneous catalyst is prepared by using cheap and easily available DVB as a polymerization cross-linking agent through an AIBN-initiated olefin polymerization method, and has the advantages of low preparation cost and simple preparation method. Meanwhile, the catalytic activity of the catalyst is obviously higher than that of reported catalysts, and the catalyst has a wide practical application prospect.

Borane-Trimethylamine Complex as a Reducing Agent for Selective Methylation and Formylation of Amines with CO2

We report herein that a borane-trimethylamine complex worked as an efficient reducing agent for the selective methylation and formylation of amines with 1 atm CO2 under metal-free conditions. 6-Amino-2-picoline serves as a highly efficient catalyst for the methylation of various secondary amines, whereas in its absence, the formylation of primary and secondary amines was achieved in high yield with high chemoselectivity. Mechanistic studies suggest that the 6-amino-2-picoline-borane catalytic system operates like an intramolecular frustrated Lewis pair to activate CO2.

Tetracoordinate borates as catalysts for reductive formylation of amines with carbon dioxide

We report sodium trihydroxyaryl borates as the first robust tetracoordinate organoboron catalysts for reductive functionalization of CO2. These catalysts, easily synthesized from condensing boronic acids with metal hydroxides, activate main group element-hydrogen (E-H) bonds efficiently. In contrast to BX3 type boranes, boronic acids and metal-BAr4 salts, under transition metal-free conditions, sodium trihydroxyaryl borates exhibit high reactivity of reductive N-formylation toward a variety of amines (106 examples), including those with functional groups such as ester, olefin, hydroxyl, cyano, nitro, halogen, MeS-, ether groups, etc. The over-performance to catalyze formylation of challenging pyridyl amines affords a promising alternative method to the use of traditional formylation reagents. Mechanistic investigation supports electrostatic interactions as the key for Si/B-H activation, enabling alkali metal borates as versatile catalysts for hydroborylation, hydrosilylation, and reductive formylation/methylation of CO2.