749928-88-9

Basic information

• Product Name: 1-(4-BroMo-2-fluorophenyl)cyclopropane-1-carbonitrile
• Synonyms: 1-(4-BroMo-2-fluorophenyl)cyclopropane-1-carbonitrile;1-(4-bromo-2-fluorophenyl)cyclopropanecarbonitrile
• CAS NO: 749928-88-9
• Molecular Formula: C₁₀H₇BrFN
• Molecular Weight: 240.0716832
• Mol File: 749928-88-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Very Slightly)
• CAS DataBase Reference: 1-(4-BroMo-2-fluorophenyl)cyclopropane-1-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BroMo-2-fluorophenyl)cyclopropane-1-carbonitrile(749928-88-9)
• EPA Substance Registry System: 1-(4-BroMo-2-fluorophenyl)cyclopropane-1-carbonitrile(749928-88-9)

Safety Data

• Hazardous Substances Data: 749928-88-9(Hazardous Substances Data)

Usage

General Description

1-(4-Bromo-2-fluorophenyl)cyclopropane-1-carbonitrile is a chemical compound with the molecular formula C10H7BrFNC. It is a derivative of cyclopropane and contains a benzene ring with a bromine and fluorine substituent, as well as a nitrile group. 1-(4-BroMo-2-fluorophenyl)cyclopropane-1-carbonitrile is commonly used in pharmaceutical research and development due to its potential biological activity. It may be utilized as a building block for the synthesis of various pharmaceutical compounds, or as a starting material for the production of more complex drug molecules. Its cyclopropane structure may also contribute to its potential pharmacological properties. Overall, 1-(4-Bromo-2-fluorophenyl)cyclopropane-1-carbonitrile has applications in medicinal chemistry and drug discovery.

Upstream product

• 114897-91-5 (4-bromo-2-fluorophenyl)acetonitrile 
• 107-04-0 1-Bromo-2-chloroethane 
• 76283-09-5 4-bromo-2-fluorobenzyl bromide 
• 106-93-4 ethylene dibromide 

Downstream Products

• 872422-15-6 1-(4-bromo-2-fluorophenyl)cyclopropane-1-carboxylic acid 
• 1403396-15-5 1-(4-bromo-2-fluorophenyl)cyclopropanecarbohydrazide 
• 1403396-16-6 3-[1-(4-bromo-2-fluorophenyl)cyclopropyl]-8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine 
• 1403395-19-6 {3-[1-(3-fluorobiphenyl-4-yl)cyclopropyl]-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl}methanol 
• 1403396-18-8 8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-[1-(2-fluoro-4-pyridin-3-ylphenyl)cyclopropyl]-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine 
• 1403395-20-9 {3-[1-(2-fluoro-4-pyridin-3-ylphenyl)cyclopropyl]-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl}methanol 
• 1403396-88-2 8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-{1-[2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl]cyclopropyl}-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine 
• 1403395-85-6 (3-{1-[2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl]cyclopropyl}-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl)methanol 
• 1403396-89-3 (8R)-3-[1-(4-bromo-2-fluorophenyl)cyclopropyl]-8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine 
• 1403396-90-6 (8R)-8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-{1-[2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl]cyclopropyl}-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine 
• 1403395-86-7 {(8R)-3-{1-[2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl]cyclopropyl}-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl}methanol 
• 1403396-99-5 (8R)-8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-{1-[2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropyl}-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine 
• 1403397-00-1 (8R)-8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-{1-[2-fluoro-4-(6-methylpyridazin-3-yl)phenyl]cyclopropyl}-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine 
• 1403395-94-7 [(8R)-3-{1-[2-fluoro-4-(6-methylpyridazin-3-yl)phenyl]cyclopropyl}-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl]methanol 

Relevant articles and documents

The diastereoselective synthesis of 2,3-diaryl-3-cyano-substituted pyrrolidines via the MgI2 mediated ring expansion of aryl cyclopropyl nitriles

The MgI2 mediated reaction of aryl substituted cyclopropyl nitriles with tosyl aldimines to give 2,3-diaryl-3-cyano-substituted pyrrolidines has been demonstrated. In all cases, the trans-diastereoisomer was determined to be the major product.

TETRAHYDROTHIAZEPINE DERIVATIVE

The present invention relates to a compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof having an excellent effect of inhibiting 11β-hydroxysteroid dehydrogenase type 1: General formula (I) wherein R1 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from substituent group A or a heterocyclic group that may be substituted with 1 to 4 group(s) independently selected from substituent group A; R2 independently represents a halogen atom or a C1-C6 alkyl group; n represents an integer of 0 to 2; and substituent group A represents the group consisting of halogen atoms, C1-C6 alkyl groups, and so forth.

INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME

The invention relates to compounds of the formula (I) and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula (I), and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula (I). The invention also relates to methods of preparing the compounds of formula (I).