872422-15-6

Basic information

• Product Name: 1-(4-BroMo-2-fluorophenyl)cyclopropanecarboxylic acid
• Synonyms: 1-(4-BroMo-2-fluorophenyl)cyclopropanecarboxylic acid;1-(4-BroMo-2-fluorophenyl)cyclopropane-1-carboxylic acid
• CAS NO: 872422-15-6
• Molecular Formula: C₁₀H₈BrFO₂
• Molecular Weight: 259.0717232
• Mol File: 872422-15-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 350.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.744±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.81±0.20(Predicted)
• CAS DataBase Reference: 1-(4-BroMo-2-fluorophenyl)cyclopropanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BroMo-2-fluorophenyl)cyclopropanecarboxylic acid(872422-15-6)
• EPA Substance Registry System: 1-(4-BroMo-2-fluorophenyl)cyclopropanecarboxylic acid(872422-15-6)

Safety Data

• Hazardous Substances Data: 872422-15-6(Hazardous Substances Data)

Usage

General Description

1-(4-Bromo-2-fluorophenyl)cyclopropanecarboxylic acid is a chemical compound with a cyclopropane ring and a carboxylic acid functional group. It is a member of the cyclopropane carboxylic acid family, which has been studied for their potential pharmacological activities. This particular compound contains a bromine and fluorine atom on the phenyl ring, making it an important intermediate for the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and properties make it a valuable building block for the creation of new chemical compounds with potential applications in medicine, agriculture, and other industries.

Upstream product

• 114897-91-5 (4-bromo-2-fluorophenyl)acetonitrile 
• 107-04-0 1-Bromo-2-chloroethane 
• 749928-88-9 1-(4-bromo-2-fluorophenyl)cyclopropane-1-carbonitrile 
• 76283-09-5 4-bromo-2-fluorobenzyl bromide 

Downstream Products

• 1403396-15-5 1-(4-bromo-2-fluorophenyl)cyclopropanecarbohydrazide 
• 1403396-16-6 3-[1-(4-bromo-2-fluorophenyl)cyclopropyl]-8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine 
• 1403395-19-6 {3-[1-(3-fluorobiphenyl-4-yl)cyclopropyl]-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl}methanol 
• 1403396-18-8 8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-[1-(2-fluoro-4-pyridin-3-ylphenyl)cyclopropyl]-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine 
• 1403395-20-9 {3-[1-(2-fluoro-4-pyridin-3-ylphenyl)cyclopropyl]-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl}methanol 
• 1403396-88-2 8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-{1-[2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl]cyclopropyl}-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine 
• 1403395-85-6 (3-{1-[2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl]cyclopropyl}-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl)methanol 
• 1403396-89-3 (8R)-3-[1-(4-bromo-2-fluorophenyl)cyclopropyl]-8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine 
• 1403396-90-6 (8R)-8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-{1-[2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl]cyclopropyl}-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine 
• 1403395-86-7 {(8R)-3-{1-[2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl]cyclopropyl}-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl}methanol 
• 1403396-99-5 (8R)-8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-{1-[2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropyl}-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine 
• 1403397-00-1 (8R)-8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-{1-[2-fluoro-4-(6-methylpyridazin-3-yl)phenyl]cyclopropyl}-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine 
• 1403395-94-7 [(8R)-3-{1-[2-fluoro-4-(6-methylpyridazin-3-yl)phenyl]cyclopropyl}-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl]methanol 
• 827628-31-9 [1-(4-bromo-2-fluorophenyl)cyclopropyl]carbamic acid tert-butyl ester 

Relevant articles and documents

TETRAHYDROTHIAZEPINE DERIVATIVE

The present invention relates to a compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof having an excellent effect of inhibiting 11β-hydroxysteroid dehydrogenase type 1: General formula (I) wherein R1 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from substituent group A or a heterocyclic group that may be substituted with 1 to 4 group(s) independently selected from substituent group A; R2 independently represents a halogen atom or a C1-C6 alkyl group; n represents an integer of 0 to 2; and substituent group A represents the group consisting of halogen atoms, C1-C6 alkyl groups, and so forth.

AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS

The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.