75-25-2

Basic information

• Product Name: Bromoform
• Synonyms: Methenyl tribromide;NSC 8019;Tribromomethane;Tribromomethane;Methyl tribromide;Tribrommethan;NCI-C55130;CCRIS 98
• CAS NO: 75-25-2
• Molecular Formula: CHBr₃
• Molecular Weight: 252.73
• EINECS: 200-854-6
• Mol File: 75-25-2.mol
• Article Data: 36

Chemical Properties

• Melting Point: 5-8℃
• Boiling Point: 149.2 °C at 760 mmHg
• Flash Point: 44 °C
• Appearance: colourless to yellow liquid
• Density: 2.997 g/cm³
• Vapor Pressure: 5.17mmHg at 25°C
• Refractive Index: 1.619
• Water Solubility: slightly soluble, 0.301 g/100 mL
• CAS DataBase Reference: Bromoform(CAS DataBase Reference)
• NIST Chemistry Reference: Bromoform(75-25-2)
• EPA Substance Registry System: Bromoform(75-25-2)

Safety Data

• Hazard Codes: T:Toxic;;
• Statements: R22:; R23:; R36/38:; R51/53:
• Safety Statements: S28A:; S45:; S61:
• RIDADR: 2515
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 75-25-2(Hazardous Substances Data)

Usage

General Description

Bromoform is a heavy, colorless, oily liquid that belongs to the group of organic compounds known as haloforms. It is primarily used as a solvent, as an intermediate in the production of various chemicals, and as a sedative in medicine. Bromoform is also produced naturally by marine organisms such as algae and plankton, and is found in small amounts in seawater. However, it is considered to be a hazardous chemical, as it is a potential carcinogen and can have harmful effects on the kidneys, liver, and central nervous system. Due to its potential health risks and environmental concerns, the use and production of bromoform are heavily regulated in many countries.

InChI:InChI=1/CHBr3/c2-1(3)4/h1H

Synthetic route

1'-naphthacetophenone (941-98-0) → Bromoform (75-25-2) + methyl 1-naphthoate (2459-24-7) + trimethyl orthoformate (149-73-5)

Conditions	Yield
With methanol; sodium bromide at 30℃; electrolysis (Pt-anode, Cu-Zn (60:40)-cathode, 220 mA/cm2 constant current density);	A n/a B 88% C n/a

1-(4-methoxyphenyl)ethanone (100-06-1) → Bromoform (75-25-2) + methyl 4-methoxybenzoate (121-98-2) + trimethyl orthoformate (149-73-5)

Conditions	Yield
With methanol; sodium bromide at 30℃; electrolysis (Pt-anode, Cu-Zn (60:40)-cathode, 220 mA/cm2 constant current density);	A n/a B 85% C n/a

adamantane (281-23-2) + acetonitrile (75-05-8) → 1-Adamantyl bromide (768-90-1) + Bromoform (75-25-2) + 1-adamantanecarbonitrile (23074-42-2)

Conditions	Yield
With carbon tetrabromide; molybdenum hexacarbonyl at 140 - 160℃; for 6h; Reactivity; Mechanism; Reagent/catalyst;	A 15% B n/a C 85%

carbon tetrabromide (558-13-4) → hexabromoethane (594-73-0) + Bromoform (75-25-2)

Conditions	Yield
With 2+ In water; acetonitrile at 20℃; Mechanism; Rate constant; Product distribution;	A 4% B 84%
With Co(II)W12O407-; sodium perchlorate In water; acetonitrile at 20℃; for 2h; Rate constant; Product distribution; pH 7; reaction in MeCN/D2O; reaction between CBr4 and the heteropoly blues Co(II)W12O407- and Co(II)W12O408-, kinetic and product stidy, effect of inert salts,;	A 1 % Spectr. B 77 % Spectr.

para-methylacetophenone (122-00-9) → 4-methyl-benzoic acid methyl ester (99-75-2) + Bromoform (75-25-2) + trimethyl orthoformate (149-73-5)

Conditions	Yield
With methanol; sodium bromide at 30℃; electrolysis (Pt-anode, Cu-Zn (60:40)-cathode, 220 mA/cm2 constant current density);	A 83% B n/a C n/a

acetophenone (98-86-2) → benzoic acid methyl ester (93-58-3) + Bromoform (75-25-2) + trimethyl orthoformate (149-73-5)

Conditions	Yield
With methanol; sodium bromide at 30℃; for 4h; Product distribution; Mechanism; electrolysis (Pt-anode, Cu-Zn (60:40) cathode, 220 mA/cm2 constant current); other electrolyte, other electrolyte-to-substrate ratio, other material of electrodes;	A 74% B n/a C 15%
With methanol; sodium bromide at 30℃; for 4h; electrolysis (Pt-anode, Cu-Zn (60:40)-cathode, 220 mA/cm2 constant current density);	A 74% B n/a C n/a

1-hexene (592-41-6) + carbon tetrabromide (558-13-4) → Bromoform (75-25-2) + 1,1,1,3-tetrabromoheptane (3740-44-1) + 1,1,3-tribromoheptane (90278-16-3) + 5,7,7,9-tetrabromotridecane

Conditions	Yield
With 2,2'-azobis(isobutyronitrile) at 80℃; for 4h; Product distribution; further reagent, further conditions;	A 3.7% B 70% C 10.1% D 9.1%
With 2,2'-azobis(isobutyronitrile) at 80℃; for 4h;	A 3.7% B 70% C 10.1% D 9.1%

di(tert-butyl)(n-butyl)phosphine (29949-72-2) → Bromoform (75-25-2) + butyl-di-t-butylchlorophosphonium bromide (81193-50-2)

Conditions	Yield
With carbon tetrabromide; hydrogen chloride In diethyl ether 1) -120 deg C to -50 deg C 2) 0 deg C, Et2O;	A 70% B 70%

3-methyl-butan-2-one (563-80-4) → Bromoform (75-25-2) + Methyl isobutyrate (547-63-7) + trimethyl orthoformate (149-73-5)

Conditions	Yield
With methanol; sodium bromide at 30℃; electrolysis (Pt-anode, Cu-Zn (60:40)-cathode, 220 mA/cm2 constant current density);	A n/a B 67% C n/a

4,5-Dimethoxy-2-(2-phenylethyl)acetophenon (106053-65-0) → Bromoform (75-25-2) + 2-Brom-4,5-dimethoxybibenzyl (106053-67-2) + 4,5-Dimethoxy-2-(2-phenylethyl)benzoesaeure (106053-50-3)

Conditions	Yield
With sodium hydroxide; bromine In 1,4-dioxane for 1h; Ambient temperature;	A n/a B 2% C 65%
With sodium hydroxide; bromine In 1,4-dioxane for 1h; Ambient temperature;	A n/a B 2% C 65%

hexyl-methyl-ketone (111-13-7) → Bromoform (75-25-2) + 2,2-dimethoxy-3-octanol (19841-72-6) + methyl heptanoate (106-73-0) + trimethyl orthoformate (149-73-5)

Conditions	Yield
With methanol; sodium bromide at 30℃; electrolysis (Pt-anode, Cu-Zn (60:40)-cathode, 220 mA/cm2 constant current density);	A n/a B 29% C 62% D n/a
With methanol; sodium bromide at 30℃; electrolysis (Pt-anode, Cu-Zn (60:40)-cathode, 220 mA/cm2 constant current density);	A n/a B 29% C 62% D n/a

1-Phenylbut-1-en-3-one (122-57-6) → Bromoform (75-25-2) + methyl cinnamate (103-26-4) + trimethyl orthoformate (149-73-5)

Conditions	Yield
With methanol; sodium bromide at 30℃; electrolysis (Pt-anode, Cu-Zn (60:40)-cathode, 220 mA/cm2 constant current density);	A n/a B 61% C n/a

methane (34557-54-5) → methyl bromide (74-83-9) + Bromoform (75-25-2) + carbon tetrabromide (558-13-4) + 1,2-dibromomethane (74-95-3)

Conditions	Yield
With bromine at 500℃; Product distribution; Further Variations:; Temperatures; Bromination;	A 17.4% B 0.48% C 2.5% D 5%

tetrachloromethane (56-23-5) + N-(2,2,2-tribromo-1-hydroxy-ethyl)-butyramide (108565-60-2) → butanamide (541-35-5) + Bromoform (75-25-2)

tetrachloromethane (56-23-5) + N-(2,2,2-tribromo-1-hydroxy-ethyl)-octanamide → Bromoform (75-25-2) + n-octanamide (629-01-6)

bromal (115-17-3) → Bromoform (75-25-2)

Conditions	Yield
With potassium carbonate

5-phenyl-cyclohexane-1,3-dione (493-72-1) → Bromoform (75-25-2) + 3-phenylglutaric acid (4165-96-2)

Conditions	Yield
With sodium hypobromide

ethyl bromide (74-96-4) + chloroform (67-66-3) → Bromoform (75-25-2)

Conditions	Yield
With aluminium trichloride

HacacBr (72997-31-0) + furan-2,3,5(4H)-trione pyridine (1:1) → Bromoform (75-25-2) + acetic acid (64-19-7) + acetone (67-64-1)

methane (34557-54-5) → Bromoform (75-25-2) + 1,2-dibromomethane (74-95-3)

Conditions	Yield
With bromine at 400℃;

ethanol (64-17-5) + carbon tetrabromide (558-13-4) → ethyl bromide (74-96-4) + Bromoform (75-25-2) + acetaldehyde (75-07-0)

Conditions	Yield
at 150℃;

ethanol (64-17-5) + tribromoacetic acid (75-96-7) → Bromoform (75-25-2)

ethanol (64-17-5) → Bromoform (75-25-2)

Conditions	Yield
With calcium bromide
With calcium bromide Electrolysis;
With potassium bromide Electrolysis;
With potassium bromide Electrolysis;
With calcium bromide Electrolysis;

malic acid (617-48-1) → Bromoform (75-25-2)

Conditions	Yield
With bromine

chloroform (67-66-3) → Bromoform (75-25-2)

Conditions	Yield
With aluminum tri-bromide
With aluminum tri-bromide
With aluminum tri-bromide; hydrogen bromide

carbon tetrabromide (558-13-4) + dimethyl phenylphosphonite (18351-42-3) → Bromoform (75-25-2)

carbon tetrabromide (558-13-4) → Bromoform (75-25-2)

Conditions	Yield
With alkaline arsenite
With alkaline sulfite
With phenylhydrazine

3,4,4-trimethyl-2-pentanone (5340-45-4) → Bromoform (75-25-2) + 2,3,3-trimethylbutanoic acid (19910-29-3)

Conditions	Yield
With sodium hypobromide

arsonoacetic acid (107-38-0) → Bromoform (75-25-2) + tribromoacetic acid (75-96-7)

Conditions	Yield
With bromine

tribromoacetyl-urea (88982-70-1) → BIURET (108-19-0) + Bromoform (75-25-2)

Conditions	Yield
With ammonia; water

methanol (67-56-1) + Bromoform (75-25-2) → trimethyl orthoformate (149-73-5)

Conditions	Yield
With sodium at 30℃; for 4h;	100%

1-methyl-4-isopropenylbenzene (1195-32-0) + Bromoform (75-25-2) → 1-(2,2-dibromo-1-methylcyclopropyl)-4-methylbenzene (87959-45-3)

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In dichloromethane; water at 40 - 45℃; for 22h; Inert atmosphere;	100%
With sodium hydroxide In dichloromethane at 40℃;	73%
With potassium tert-butylate In hexane at 0℃; for 2h;	50%

Bromoform (75-25-2) + Bis(2,4,6-tri-tert-butylphenyl)diphosphen (83466-54-0, 93602-74-5, 79073-99-7) → 1,2-bis(2,4,6-tri-tert-butylphenyl)3,3-dibromo diphosphirane (111888-02-9)

Conditions	Yield
With potassium hydroxide In hexane at 15℃; for 2h; sonication;	100%
With n-butyllithium In diethyl ether at 0℃;
With potassium tert-butylate CBr4 + n-BuLi is also possible;

Bromoform (75-25-2) → trimethyl orthoformate (149-73-5)

Conditions	Yield
With methanol; sodium at 30℃; electrolysis (Pt-anode, Cu-Zn (60:40)-cathode, 220 mA/cm2 constant current density);	100%
With methanol; sodium at 30℃; for 4h; Product distribution; electrolysis (Pt-anode, Cu-Zn (60:40) cathode, 220 mA/cm2 constant current); reaction with NaBr/CH3OH;	100%

4-heptanone (123-19-3) + Bromoform (75-25-2) → 4-(Tribromomethyl)heptan-4-ol (258504-48-2)

Conditions	Yield
Stage #1: Bromoform With lithium diisopropyl amide In tetrahydrofuran; hexane at -100℃; for 0.166667h; Metallation; Stage #2: 4-heptanone With boron trifluoride diethyl etherate In tetrahydrofuran; diethyl ether; hexane at -90℃; for 4h; Addition;	100%

cycloactanone (502-49-8) + Bromoform (75-25-2) → 1-(Tribromomethyl)cyclooctan-1-ol (258504-47-1)

Conditions	Yield
Stage #1: Bromoform With lithium diisopropyl amide In tetrahydrofuran; hexane at -100℃; for 0.166667h; Metallation; Stage #2: cycloactanone With boron trifluoride diethyl etherate In tetrahydrofuran; diethyl ether; hexane at -90℃; for 4h; Addition;	100%

Bromoform (75-25-2) + 1-phenyl-propan-1-one (93-55-0) → 1,1,1-Tribromo-2-phenylbutan-2-ol (258504-50-6)

Conditions	Yield
Stage #1: Bromoform With lithium diisopropyl amide In tetrahydrofuran; hexane at -100℃; for 0.166667h; Metallation; Stage #2: 1-phenyl-propan-1-one With boron trifluoride diethyl etherate In tetrahydrofuran; diethyl ether; hexane at -90℃; for 4h; Addition;	100%

Bromoform (75-25-2) + (1S,5R,7S,9R,13S)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-13-methyl-tricyclo[7.4.1.01,5]tetradec-10-en-14-one → C23H38Br2O2Si

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In diethyl ether at 25℃; for 1h;	100%

Bromoform (75-25-2) + (η5:η5-C10H8)W2(CO)6H2 (105160-08-5) → (η5:η5-C10H8)W2(CO)6Br2 (158790-07-9)

Conditions	Yield
In diethyl ether under Ar; addn. CHBr3/ether to soln. W-complex/ether, soln. kept 2 h (crystn.); solvent decanted, solid washed (ether), dried (vac.), elem. anal.;	100%

Bromoform (75-25-2) + C26H56O5Si3 (1055313-43-3) → ((2R,3R,6S)-2-((t-butyldimethylsilyloxy)methyl)-6-(2,2-dibromocyclopropoxy)tetrahydro-2H-pyran-3,4-diyl)bis(oxy)bis(t-butyldimethylsilane)

Conditions	Yield
With potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere;	100%

methanol (67-56-1) + Bromoform (75-25-2) + 4-(5-methyl-1,3,4-oxadiazol-2-yl)benzaldehyde (179056-82-7) → 2-methoxy-2-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)acetic acid (1333472-39-1)

Conditions	Yield
Stage #1: methanol; Bromoform; 4-(5-methyl-1,3,4-oxadiazol-2-yl)benzaldehyde With potassium hydroxide In 1,4-dioxane at 20℃; Cooling with ice; Stage #2: With hydrogenchloride In water pH=1;	100%

Bromoform (75-25-2) + 4-tert-Butylstyrene (1746-23-2) → 1-(tert-Butyl)-4-(2,2-dibromocyclopropyl)-benzene

Conditions	Yield
With benzyltriethylammonium bromide; sodium hydroxide In water at 0 - 20℃; for 2h;	100%
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 0 - 60℃;	80%
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 50 - 60℃; for 2h; Inert atmosphere;
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 50 - 60℃; Inert atmosphere;
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 20 - 60℃;

trans-(η(5)-pentamethylcyclopentadienyl)(dicarbonyl)(dihydrido)rhenium (156042-18-1, 81741-00-6, 145842-96-2) + Bromoform (75-25-2) → trans-(η(5)-pentamethylcyclopentadienyl)(dibromo)(dicarbonyl)rhenium

Conditions	Yield
Heating; Schlenk technique;	100%

Bromoform (75-25-2) + (η5:η5-4,4',5,5'-tetra-tert-butylfulvalene)[Ir(CO)2]2 + benzene (71-43-2) → (η5:η5-4,4',5,5'-tetratert-butylfulvalene)[Ir(CO)(Ph)(Br)][Ir(CO)(Br)2] + (η5:η5-4,4',5,5'-tetratert-butylfulvalene)[Ir(CO)(Ph)(Br)]2

Conditions	Yield
Stage #1: (η5:η5-4,4',5,5'-tetra-tert-butylfulvalene)[Ir(CO)2]2; benzene for 8h; Irradiation; Inert atmosphere; Stage #2: Bromoform at 50℃; for 12h;	A 100% B 100%

Bromoform (75-25-2) + 1-ethylstyrene (2039-93-2) → 2,2-dibromo-1-ethyl-1-phenylcyclopropane (66444-06-2)

Conditions	Yield
With cetyltrimethylammonim bromide; sodium hydroxide In dichloromethane; water at 5℃;	99%
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 20 - 60℃; Inert atmosphere;	80%
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 20 - 60℃; Inert atmosphere;	80%

Bromoform (75-25-2) + 3-(1-methoxy-1-methylethoxy)prop-1-ene (62322-46-7) → 1,1-Dibromo-2-[(1-methoxy-1-methylethoxy)methyl]cyclopropan (259194-62-2)

Conditions	Yield
With cetyltrimethylammonim bromide; triethylamine In dichloromethane at 20℃; for 48h; cyclocondensation;	99%

Bromoform (75-25-2) + (E)-1-(Trimethylsilyl)-2-nonene (63922-74-7) → trans-1,1-dibromo-2-hexyl-3-(trimethylsilylmethyl)cyclopropane

Conditions	Yield
With potassium tert-butylate In hexane at 0 - 20℃;	99%

Bromoform (75-25-2) + (E)-trimethyl(3-phenylallyl)silane (40595-34-4) → trans-1,1-dibromo-2-phenyl-3-(trimethylsilylmethyl)cyclopropane

Conditions	Yield
With potassium tert-butylate In hexane at 0 - 20℃;	99%

Bromoform (75-25-2) + 2-methylhept-1-ene (15870-10-7) → 1,1-dibromo-2-methyl-2-pentyl-cyclopropane (197661-72-6)

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In dichloromethane; water at 40 - 45℃; for 22h; Inert atmosphere;	99%
With sodium hydroxide; tetrabutylammomium bromide In water at 55℃; for 1h;

Bromoform (75-25-2) + 1-chloro-4-(1-methylethenyl)-benzene (1712-70-5) → 1-chloro-4-(2,2-dibromo-1-methylcyclopropyl)benzene (1064000-89-0)

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 20 - 60℃; Inert atmosphere;	99%
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 20 - 60℃; Inert atmosphere;	99%
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In dichloromethane; water at 40 - 45℃; for 22h; Inert atmosphere;	93%

(E)-2-Hexen-1-ol (928-95-0) + Bromoform (75-25-2) → C7H12Br2O

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In water	99%

Bromoform (75-25-2) + 1-methyl-2-vinyl-benzene (611-15-4) → 1-(2,2-dibromocyclopropyl)-2-methylbenzene (132608-14-1)

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 20 - 60℃; Inert atmosphere;	99%
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 50 - 60℃; for 2h;	41%
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 50 - 60℃; for 2h; Inert atmosphere;

Bromoform (75-25-2) + 4-(tert-butyldiphenylsilyloxy)hepta-1,6-diene (175164-50-8) → C22H26Br2OSi

Conditions	Yield
Stage #1: 4-(tert-butyldiphenylsilyloxy)hepta-1,6-diene With Grubbs catalyst first generation In dichloromethane at 20℃; for 0.333333h; Inert atmosphere; Stage #2: Bromoform With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In dichloromethane for 6h; Inert atmosphere; Sonication;	99%

Bromoform (75-25-2) + 4-(vinyl-β,β-d2)-1,1'-biphenyl (57204-39-4) → 4-(2,2-dibromocyclopropyl-3,3-d2)-1,1'-biphenyl

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 20 - 60℃; Inert atmosphere;	99%
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 20 - 60℃; Inert atmosphere;	99%

2,3-Dimethyl-2-butene (563-79-1) + Bromoform (75-25-2) → 2,2,3,3-tetramethyl-1,1-dibromocyclopropane (22715-57-7)

Conditions	Yield
With potassium tert-butylate In n-heptane at -9 - 20℃; for 4h;	98%
With potassium tert-butylate In pentane	95%
With potassium tert-butylate In n-heptane at -10 - 20℃; Inert atmosphere; Industrial scale;	76%

Bromoform (75-25-2) + isobutene (115-11-7) → 1,1-dibromo-2,2-dimethylcyclopropane (32264-50-9)

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In ethanol; dichloromethane for 5h;	98%
With potassium tert-butylate In tert-butyl alcohol; pentane at 0℃; for 14h;	93%
With potassium tert-butylate at -25℃;	91%

Bromoform (75-25-2) + 2,3-dimethyl-buta-1,3-diene (513-81-5) → 2,2,2',2'-tetrabromo-1,1'-dimethyl-1,1'-bicyclopropyl (62405-61-2)

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane for 1.5h; ultrasound treatment;	98%
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride 1.) 30 min, 0 deg C, 2.) 2 d, r.t.;	63%
With sodium hydroxide	35%
With potassium tert-butylate In pentane

Bromoform (75-25-2) + 3-methylenetetracyclo<3.2.0.02,7,04,6>heptane (38898-42-9) → 2,2-Dibromspiro2,7.04,6>heptan> (81787-72-6)

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride at 40℃; for 4h;	98%
With potassium tert-butylate In hexane at 0℃; for 0.75h;	72%

Bromoform (75-25-2) + 4-(Methylthio)benzaldehyde (3446-89-7) → 2-hydroxy-2-(4-methylthiophenyl)ethanoic acid (109086-16-0)

Conditions	Yield
With sodium hydroxide; lithium bromide In 1,4-dioxane	98%
With potassium hydroxide; lithium bromide In 1,4-dioxane; water 1.) 0 deg C, 18 h, 2.) 23 deg C, 24 h;	7.6 g

Bromoform (75-25-2) + cycloheptanone (502-42-1) → 1-hydroxycycloheptanecarboxylic acid (20920-03-0)

Conditions	Yield
With potassium hydroxide for 1h; Ambient temperature;	98%

Upstream product

• 56-23-5 tetrachloromethane 
• 108565-60-2 N-(2,2,2-tribromo-1-hydroxy-ethyl)-butyramide 
• 493-72-1 5-phenyl-cyclohexane-1,3-dione 
• 64-17-5 ethanol 
• 558-13-4 carbon tetrabromide 
• 617-48-1 malic acid 
• 67-66-3 chloroform 
• 5340-45-4 3,4,4-trimethyl-2-pentanone 
• 88982-70-1 tribromoacetyl-urea 
• 855235-60-8 3-ethanesulfonyl-1,1,1,3-tetrabromo-butan-2-one 
• 98143-30-7 N-(2,2,2-tribromo-1-hydroxy-ethyl)-propionamide 
• 108565-61-3 N-(2,2,2-tribromo-1-hydroxy-ethyl)-isobutyramide 
• 1509-54-2 N-(2,2,2-tribromo-1-hydroxy-ethyl)-hexanamide 
• 623-11-0 1-methyl-4-nitrosobenzene 

Downstream Products

• 3430-31-7 3-bromo-2,6-dimethylpyridine 
• 99058-02-3 1,1-dibromo-2-(phenylmethyl)cyclopropane 
• 626-55-1 3-Bromopyridine 
• 22715-57-7 2,2,3,3-tetramethyl-1,1-dibromocyclopropane 
• 74-95-3 1,1-dibromomethane 
• 74-83-9 methyl bromide 
• 34557-54-5 methane 
• 74-84-0 ethane 
• 74-86-2 acetylene 
• 519-73-3 triphenylmethane 
• 2294-94-2 1,1,1,2-tetraphenylethane 
• 23511-78-6 1,1,3-trichloropropane 
• 75-27-4 bromodichloromethane 
• 124-48-1 chlorodibromomethane 

Relevant articles and documents

One-Pot Conversion of Methane to Light Olefins or Higher Hydrocarbons through H-SAPO-34-Catalyzed in Situ Halogenation

Methane was converted to light olefins (ethene and propene) or higher hydrocarbons in a continuous flow reactor below 375 °C over H-SAPO-34 catalyst via an in situ halogenation (chlorination/bromination) protocol. The reaction conditions can be efficiently tuned toward selective monohalogenation of methane to methyl halides or their in situ oligomerization to higher hydrocarbons. The presence of C5+ hydrocarbons in the reaction products clearly indicates that by using a properly engineered catalyst under optimized reaction conditions, hydrocarbons in the gasoline range can be produced. This approach has significant potential for feasible application in natural gas refining to gasoline and materials under moderate operational conditions.

Bromination of hydrocarbons with CBr4, initiated by light-emitting diode irradiation

The bromination of hydrocarbons with CBr4 as a bromine source, induced by light-emitting diode (LED) irradiation, has been developed. Monobromides were synthesized with high efficiency without the need for any additives, catalysts, heating, or inert conditions. Action and absorption spectra suggest that CBr4 absorbs light to give active species for the bromination. The generation of CHBr3 was confirmed by NMR spectroscopy and GC-MS spectrometry analysis, indicating that the present bromination involves the homolytic cleavage of a C-Br bond in CBr4 followed by radical abstraction of a hydrogen atom from a hydrocarbon.