75853-08-6Relevant articles and documents
C(sp2)-F Oxidative Addition of Fluorinated Aryl Ketones by iPrPCPIr
Wilklow-Marnell, Miles,Brennessel, William W.,Jones, William D.
, p. 3125 - 3134 (2017)
The reaction of iPrPCPIrH4 (iPrPCP = κ3-2,6-C6H3(CH2P(iPr)2)2) with ≥2 equiv of 2,3,4,5,6-pentafluoroacetophenone (AP-F5) in aromatic solvents at
Decarboxylative Polyfluoroarylation of Alkylcarboxylic Acids
Sun, Xiang,Ritter, Tobias
supporting information, p. 10557 - 10562 (2021/04/05)
Polyfluoroarenes are useful building blocks in several areas such as drug discovery, materials, and crop protection. Herein, we report the first polyfluoroarylation of aliphatic carboxylic acids via photoredox decarboxylation. The method proceeds with bro
One-pot Chemoenzymatic Deracemisation of Secondary Alcohols Employing Variants of Galactose Oxidase and Transfer Hydrogenation
Yuan, Bo,Debecker, Damien P.,Wu, Xiaofeng,Xiao, Jianliang,Fei, Qiang,Turner, Nicholas J.
, p. 6191 - 6195 (2020/10/15)
Enantiomerically enriched chiral secondary alcohols serve as valuable building blocks for drug intermediates and fine chemicals. In this study the deracemisation of secondary alcohols to generate enantiomeric pure chiral alcohols has been achieved by combining enantio-selective enzymatic oxidation of a secondary alcohol, by a variant of GOase (GOase M3-5), with either non-selective ketone reduction via transfer hydrogenation (TH) or enantio-selective asymmetric transfer hydrogenation (ATH). Both the enzymatic oxidation system and the transition-metal mediated reduction system were optimised to ensure compatibility with each other resulting in a homogeneous reaction system. 1-(4-nitrophenyl)ethanol was generated with 99 % conversion and 98 % ee by the deracemisation method, and it has been extended to a series of other secondary alcohols with comparable results.
