76-89-1

Basic information

• Product Name: Methyl benzilate
• Synonyms: alpha-hydroxy-alpha-phenyl-benzeneaceticacimethylester;alpha-Hydroxydiphenylacetic acid, methyl ester;Benzeneacetic acid, alpha-hydroxy-alpha-phenyl-, methyl ester;ethyl 2-hydroxy-2,2-diphenylacetate;ethyl a-hydroxydiphenylacetate;ethyl a-phenylmandelate;ethyl hydroxydiphenylacetate;Methyl benzillate
• CAS NO: 76-89-1
• Molecular Formula: C₁₅H₁₄O₃
• Molecular Weight: 242.27
• EINECS: 200-991-1
• Product Categories: Aromatic Esters
• Mol File: 76-89-1.mol
• Article Data: 35

Chemical Properties

• Melting Point: 73 °C
• Boiling Point: 187 °C
• Flash Point: 187°C/13mm
• Appearance: white crystalline powder
• Density: 1.1515 (rough estimate)
• Vapor Pressure: 0.000134mmHg at 25°C
• Refractive Index: 1.5570 (estimate)
• PKA: 11.38±0.29(Predicted)
• Water Solubility: Soluble in methanol. Insoluble in water.
• Merck: 14,1080
• BRN: 2121492
• CAS DataBase Reference: Methyl benzilate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl benzilate(76-89-1)
• EPA Substance Registry System: Methyl benzilate(76-89-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 22-24/25
• TSCA: Yes
• Hazardous Substances Data: 76-89-1(Hazardous Substances Data)

Usage

Chemical Properties

WHITE FINE CRYSTALLINE POWDER

Uses

It is used as a pharmaceutical intermediate.

InChI:InChI=1/C15H14O3/c1-18-14(16)15(17,12-8-4-2-5-9-12)13-10-6-3-7-11-13/h2-11,17H,1H3

Upstream product

• 67-56-1 methanol 
• 76-93-7 Benzilic acid 
• 768-49-0 (2-methyl-1-propenyl)-benzene 
• 538-74-9 dibenzyl sulfide 
• 54311-64-7 methyl α-chloro-α-phenylbenzeneacetate 
• 769-57-3 α,β,β-trimethylstyrene 
• 74-88-4 methyl iodide 
• 57272-44-3 methyl α-hydroperoxy-α,α-diphenylacetate 
• 124-41-4 sodium methylate 
• 134-81-6 benzil 
• 101-41-7 benzeneacetic acid methyl ester 
• 22979-35-7 Methyl phenyldiazoacetate 
• 616-38-6 carbonic acid dimethyl ester 
• 1634-04-4 tert-butyl methyl ether 

Downstream Products

• 853787-58-3 acetoacetyloxy-diphenyl-acetic acid methyl ester 
• 28789-59-5 benzilic acid-(1-ethyl-[4]piperidyl ester) 
• 31416-65-6 N-(2-dimethylamino-ethyl)-benzilamide 
• 117866-86-1 1,1-bis-(4-methoxy-phenyl)-2,2-diphenyl-ethane-1,2-diol 
• 53484-68-7 glypin 
• 116179-15-8 benzilic acid-(6exo,7exo-dimethoxy-tropane-3endo-yl ester) 
• 1091-30-1 Benzilsaeure-<2-methylamino-aethylester> 
• 2902-93-4 2-(Diethylamino)-propyl-benzilsaeureester 
• 39943-07-2 benzilic acid-(3-dimethylamino-2,2-dimethyl-propyl ester) 
• 94915-14-7 Benzilsaeure-<2-(N-methyl-N-(2-hydroxyaethyl)-amino)-aethylester> 
• 71290-92-1 Methyl-bis-(2-hydroxy-aethyl)-amin-dibenzilat 
• 94914-83-7 benzilic acid-(2-dimethylamino-propyl ester) 
• 60204-83-3 hydroxy-diphenyl-acetic acid 4a,6a-dimethyl-tetrahydro-1,4-dioxa-6b-aza-cyclopenta[cd]pentalen-2a-ylmethyl ester 
• 118108-61-5 1-benzylpiperidin-4-yl 2-hydroxy-2,2-diphenylacetate 

Relevant articles and documents

A Unified Strategy for the Asymmetric Synthesis of Highly Substituted 1,2-Amino Alcohols Leading to Highly Substituted Bisoxazoline Ligands

A general procedure for the asymmetric synthesis of highly substituted 1,2-amino alcohols in high yield and diastereoselectivity is described that uses organometallic additions of a wide range of nucleophiles to tert-butylsulfinimines as the key step. The addition of organolithium reagents to these imines follows a modified Davis model. The diastereoselectivity for this reaction depends significantly on both the nucleophile and electrophile. These highly substituted 1,2-amino alcohols are used to synthesize stereochemically diverse and structurally novel, polysubstituted 2,2′-methylene(bisoxazoline) ligands in high yields.

Time-Economical Synthesis of Diarylacetates Enabled by TfOH-Catalyzed Arylation of α-Aryl-α-Diazoesters with Arenes

Diarylacetates are privileged structures of many bioactive natural products and pharmaceutical compounds. A time-economical synthesis of diarylacetates by TfOH-catalyzed arylation of α-aryl-α-diazoesters with arenes is described. This protocol provides a variety of diarylacetates in good yields with broad substrate scope, excellent functional group compatibility, and mild reaction conditions. Also, a new mechanism for the arylation reaction of α-aryl-α-diazoesters with arenes under TfOH catalysis is presented.

A 2 the hydroxy [...] ― 2,2 the the ― 3 α [...] diphenylgermanium acetic acid [...] (8 the [...] azabicyclo [3, 2, 1]) ― 3 the method for the preparation of octyl [...]

The invention discloses a method for preparing 2-hydroxy-2,2-diphenylacetic acid-3alpha-(8-aza-bicyclo(3,2,1))-3-trioctyl. The method comprises the following steps of: by taking dibenzoyl as a raw material, carrying out rearrangement on the raw material so as to obtain dihydroxy-phenylacetic acid; reacting dihydroxy-phenylacetic acid with dimethyl carbonate under the DBU catalysis and microwave actions so as to obtain methyl benzilate; reacting the methyl benzilate with tropine so as to obtain tropine benzilate; and carrying out N formylation and alcoholysis on the obtained tropine benzilate so as to obtain nor-tropine benzilate. Compared with the prior art, the total reaction time of the method disclosed by the invention is greatly reduced, the total yield is increased greatly, and the reaction condition is more simple, and therefore, the method is suitable for industrial production.