76017-87-3

Basic information

• Product Name: 2-(1-Cyanoethyl)indole
• Synonyms: α-Methyl-1H-indole-2-acetonitrile
• CAS NO: 76017-87-3
• Molecular Formula: C11H10N2
• Molecular Weight: 170.21
• Product Categories: Indole Derivatives;Intermediates;Aromatics;Heterocycles
• Mol File: 76017-87-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(1-Cyanoethyl)indole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-Cyanoethyl)indole(76017-87-3)
• EPA Substance Registry System: 2-(1-Cyanoethyl)indole(76017-87-3)

Safety Data

• Hazardous Substances Data: 76017-87-3(Hazardous Substances Data)

Usage

Uses

2-(1-Cyanoethyl)indole is a useful intermediate for the synthesis of pharmaceutical actives, intermediates and fine chemicals.

Upstream product

• 17954-23-3 1-ethoxycarbonyl-1,2-dihydroquinoline-2-carbonitrile 
• 52618-53-8 2-(cyanomethyl)-N-ethoxycarbonylindole 
• 7210-27-7 2-indoleacetonitrile 
• 74-88-4 methyl iodide 
• 69901-68-4 2-(1-cyanoethyl)-N-ethoxycarbonylindole 

Downstream Products

• 75240-18-5 3-amino-4-methylpyrido<4,3-b>indole acetate salt 
• 68808-54-8 Trp-P-1 acetate 

Relevant articles and documents

New 5-HT3 (serotonin-3) receptor antagonists, II. Synthesis and structure-activity relationships of pyrimido[1,6-a]indoles.

A series of pyrimido[1,6-alpha]indol-1(2H)-ones was prepared and evaluated for 5-HT3 receptor antagonist activity. The compounds in this series were regarded as bioisosters of the pyrido[1,2-alpha]indol-6(7H)-ones previously reported. High potency was found for compounds having 5-methyl substituents on both the pyrimido[1,6-alpha]indole ring and the imidazole ring. Optimized members of this series, 8b and (+)-26a, were potent 5-HT3 receptor antagonists as determined by measuring inhibition of the Bezold-Jarisch reflex in anesthetized rats (ED50 0.6 and 0.8 microgram/kg i.v., respectively), being equipotent to or more potent than FK 1052 (1) in the previous paper and 20- to 30-fold more potent than ondansetron (2).