7677-49-8

Basic information

• Product Name: 2-(1,1-DIOXO-1H-1LAMBDA6-BENZO[D]ISOTHIAZOL-3-YLAMINO)-ETHANOL
• Synonyms: 2-(1,1-DIOXO-1H-1LAMBDA6-BENZO[D]ISOTHIAZOL-3-YLAMINO)-ETHANOL;2-[(1,1-DIOXIDO-1,2-BENZISOTHIAZOL-3-YL)AMINO]ETHANOL;ethanol, 2-[(1,1-dioxido-1,2-benzisothiazol-3-yl)amino]-;EU-0014278;STK008625;ZINC02482876
• CAS NO: 7677-49-8
• Molecular Formula: C9H10N2O3S
• Molecular Weight: 226.25
• Mol File: 7677-49-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(1,1-DIOXO-1H-1LAMBDA6-BENZO[D]ISOTHIAZOL-3-YLAMINO)-ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1,1-DIOXO-1H-1LAMBDA6-BENZO[D]ISOTHIAZOL-3-YLAMINO)-ETHANOL(7677-49-8)
• EPA Substance Registry System: 2-(1,1-DIOXO-1H-1LAMBDA6-BENZO[D]ISOTHIAZOL-3-YLAMINO)-ETHANOL(7677-49-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 7677-49-8(Hazardous Substances Data)

Usage

Classification

Benzothiazole class of compounds

Applications

Industrial and scientific uses

Inhibition of PTP1B (Protein Tyrosine Phosphatase 1B)

Potent inhibitor

Potential treatment

Diabetes and obesity

Other properties

Antiviral, antitumor, and immune response modulation

Versatility

Diverse potential applications in pharmacology and biotechnology.

Upstream product

• 57683-71-3 methyl 2-(aminosulfonyl)benzoate 
• 119300-80-0 2-methoxycarbonyl-benzenesulfinic acid 
• 134-20-3 2-carbomethoxyaniline 
• 81-07-2 saccharin 
• 141-43-5 ethanolamine 
• 567-19-1 3-chloro-1,2-benzisothiazole 1,1-dioxide 

Relevant articles and documents

Synthesis, characterization and antimicrobial evaluation of new 3-(Alkyl/Arylamino)benzo[d]isothiazole 1,1-derivatives

The saccharine nucleus has long been recognized as a significant component in medicine. A series of pseudo-saccharine amines derivatives (7a-j) were synthesized and examined for their antibacterial activity. After testing all compounds, 7b, 7f, 7g, 7i and 7j were found most effective against Escherichia coli, Streptococcus aureus and Bacillus subtilis strains. The MIC of the compound was found from 4.6 to 16.1 μM. Further, compound 7f and 7i exhibited excellent activity against E.coli and Bacillus subtilis with MIC value 4.6 and 4.7 μM respectively. The compound 7b and 7i was found active against all the three bacteria. The zone inhibition was observed at 10 μM against Escherichia coli, Staphylococcus aureus and Bacillus subtilis at 0.9, 1.8, 3.9 respectively for 7b and 1.0, 1.8 and 2.0 cm respectively for 7i.

The transformation of saccharin into derivatives of imidazo[1,2-b][1,2] benzisothiazole and benzo[g][1,2,5]thiadiazocine

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