81-07-2

Basic information

• Product Name: Saccharin
• Synonyms: SACCHARIN;SACCHARIN 550X;SACCHARINE;SACCHARINE INSOLUBLE;SACCHARIN INSOLUBLE;SYNCAL (R) SDI;O-BENZOIC ACID SULFIMIDE;O-BENZOIC SULFIMIDE
• CAS NO: 81-07-2
• Molecular Formula: C₇H₅NO₃S
• Molecular Weight: 183.18
• EINECS: 201-321-0
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Sulfur;GARANTOSE;food additives
• Mol File: 81-07-2.mol
• Article Data: 43

Chemical Properties

• Melting Point: 226-229 °C(lit.)
• Boiling Point: subl
• Appearance: White/Crystals or Crystalline Powder
• Density: 0.828
• Vapor Pressure: 0Pa at 25℃
• Refractive Index: 1.5500 (estimate)
• Storage Temp.: Refrigerator
• Solubility: acetone: soluble1g in 12mL(lit.)
• PKA: 11.68(at 18℃)
• Water Solubility: 3.3 g/L (20 ºC)
• Stability: Stable. Incompatible with strong oxidizing agents.
• Merck: 14,8311
• BRN: 6888
• CAS DataBase Reference: Saccharin(CAS DataBase Reference)
• NIST Chemistry Reference: Saccharin(81-07-2)
• EPA Substance Registry System: Saccharin(81-07-2)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: 40-62-63-68
• Safety Statements: 24/25
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 2
• RTECS: DE4200000
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 81-07-2(Hazardous Substances Data)

Usage

Chemical Description

Saccharin is an artificial sweetener that is commonly used in food and drinks.

InChI:InChI=1/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)

Upstream product

• 56-23-5 tetrachloromethane 
• 808766-62-3 2-sulfamoyl-benzoyl azide 
• 88-19-7 methyl 2-(aminosulfonyl)benzoate 
• 14070-51-0 N-chlorosaccharin 
• 108-88-3 toluene 
• 5459-63-2 bis[2-(methoxycarbonyl)phenyl]disulfide 
• 6939-89-5 2-sulfo-benzoic acid ; ammonium salt 
• 68287-35-4 (2-chloro-propyl)-(1,1-dioxo-1H-1λ⁶-benzo[d]isothiazol-3-yl)-amine 
• 15246-97-6 2-(2-hydroxyimino-1-methyl-propyl)-1,1-dioxo-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-one 
• 110-91-8 morpholine 
• 104867-39-2 2,2'-thiobis(benzo-1,2-thiazolin-3-one)-1,1,1',1'-tetroxide 
• 38949-28-9 3-(3-trifluoromethyl-phenoxy)-benzo[d]isothiazole 1,1-dioxide 
• 35812-01-2 N-bromosaccharin 
• 495-40-9 propiophenone 

Downstream Products

• 15448-99-4 N-methylsaccharin 
• 6954-54-7 1,1-dioxo-2-xanthen-9-yl-1λ⁶-benz[d]isothiazol-3-one 
• 6343-81-3 2-(2-hydroxyethyl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxide 
• 57683-71-3 methyl 2-(aminosulfonyl)benzoate 
• 13947-20-1 N-(hydroxymethyl)saccharin 
• 59777-72-9 ethyl 2-(aminosulfonyl)benzoate 
• 41335-47-1 2-(4-methylbenzyl)-1,2-benzothiazol-3(2H)-one 1,1-dioxide 
• 106841-57-0 3-(4-methyl-benzyloxy)-benz[d]isothiazole-1,1-dioxide 
• 107523-42-2 2-(3,5-dimethoxy-phenacyl)-1,1-dioxo-1λ⁶-benz[d]isothiazol-3-one 
• 110513-04-7 2-sulfamoyl-benzoic acid-(2,5-dimethyl-anilide) 
• 856633-77-7 2-[3-(2-nitro-phenyl)-3-oxo-propyl]-1,1-dioxo-1λ⁶-benz[d]isothiazol-3-one 
• 7632-10-2 methamphetamin 
• 7668-23-7 3-(phenylamino)benzo[d]isothiazole 1,1-dioxide 
• 108981-66-4 2-sulfamoyl-benzoic acid-[1]naphthylamide 

Relevant articles and documents

Synthesis, characterization and antimicrobial evaluation of new 3-(Alkyl/Arylamino)benzo[d]isothiazole 1,1-derivatives

The saccharine nucleus has long been recognized as a significant component in medicine. A series of pseudo-saccharine amines derivatives (7a-j) were synthesized and examined for their antibacterial activity. After testing all compounds, 7b, 7f, 7g, 7i and 7j were found most effective against Escherichia coli, Streptococcus aureus and Bacillus subtilis strains. The MIC of the compound was found from 4.6 to 16.1 μM. Further, compound 7f and 7i exhibited excellent activity against E.coli and Bacillus subtilis with MIC value 4.6 and 4.7 μM respectively. The compound 7b and 7i was found active against all the three bacteria. The zone inhibition was observed at 10 μM against Escherichia coli, Staphylococcus aureus and Bacillus subtilis at 0.9, 1.8, 3.9 respectively for 7b and 1.0, 1.8 and 2.0 cm respectively for 7i.

Preparation method of saccharin

The invention discloses a preparation method of saccharin. The invention provides a preparation method of saccharin as shown in a formula 1 represented in the specification. The preparation method ischaracterized by comprising the following step: in water, in the presence of tungstate and/or tungstic acid, carrying out oxidation reaction on a compound shown in a formula 2 and hydrogen peroxide toobtain saccharin shown in a formula 1.

CARBON MONOXIDE PRODRUGS FOR THE TREATMENT OF MEDICAL DISORDERS

The present invention provides new compounds and compositions thereof that release carbon monoxide for the treatment of medical disorders that are responsive to carbon monoxide, for example, inflammatory, pain, and dermatological disorders.