77182-82-2 Usage
Organophosphorus herbicides
Glufosinate-ammonium, also known as glufosinate, is a non-selective foliar application of organic phosphorus herbicide, in 1979 first developed by the Federal Republic of Germany Hoechst (Hoechst) chemical synthesis company. Weeding mechanism of Glufosinate-ammonium is absorbed by the blade, having a part suction effect, can be transferred from the base of the blade to the ends, transferred less to other parts of the plant, is harmless for not unearthed shoots and seeds. Plants Glufosinate-ammonium metabolism is disordered in a short period after drug application, a strong cytotoxic agent Glufosinate-ammonium ion is accumulated in plants; poisoned the plant to die. While also severely inhibited photosynthesis, injured plants was yellowish white after lose of the green, after 2 to 5 days, turned yellow and died. After contacted with the soil, lost activity, it should only for spray of stem and leaf at postemergence.
Applications: Glufosinate-ammonium is mainly used for destuctive weeding of orchards, vineyards, potato fields, nurseries, forests, pastures, ornamental shrubs and free arable, prevention and weeding of annual and perennial weeds such as foxtail, wild oats, crabgrass , barnyard grass, green foxtail, bluegrass, quackgrass, bermudagrass, bentgrass, reeds, fescue, etc. Also prevention and weeding of broadleaf weeds such as quinoa, amaranth, smartweed, chestnut, black nightshade, chickweed, purslane, cleavers, sonchus, thistle, field bindweed, dandelion, also have some effect on sedges and ferns. When broadleaf weeds in the beginning of growing season and grass weeds in tillering period, dosage of 0.7 to 1.2 kg/hectare was sprayed on weed populations, period of weed control is 4 to 6 weeks, administration again if necessary, can significantly extend the validity period. Potato field should be used in the pre-emergence, it can also be sprayed before harvest, killing and weeding ground stubble, so as to harvest. Prevention and weeding of ferns, dosage of per hectare is 1.5 to 2 kg. Usually alone, sometimes it can also be mixed with simajine, diuron or methylchloro phenoxyacetic acid, and so on.
Figure 1 The chemical structural formula of Glufosinate-ammonium.
The above information is edited by the lookchem of Liu Yujie.
Toxicity
Male rats acute oral LD50 is 2000 mg/kg, female rats is 1620 mg/kg; male mice acute oral LD50 is 431 mg/kg, female mice is 416 mg/kg; dog acute oral LD50 is 200~400 mg/kg. Male rats acute percutaneous LD50 is > 2000 mg/kg, female rats is 4000 mg/kg. No teratogenic and carcinogenic effects. Rainbow trout LC50 is 320mg/L (96h).
Chemical properties
Low solubility in common organic solvents, solubility in water is large. At pH 5-9, hydrolysis, half-life of soil is <10d. Light stability.
Uses
Different sources of media describe the Uses of 77182-82-2 differently. You can refer to the following data:
1. Organophosphorus herbicides, glutamine synthetase inhibitors, non-selective contact herbicide. There are certain suction effect, can be used for weeding of orchards, vineyards and non-cultivated land, can also be used for prevention and weeding of annual and perennial dicotyledonous weeds and sedges in potato field, such as rat tail foxtail, crabgrass, barnyardgrass, foxtail, wild wheat, wild corn, cocksfoot, fescue, deschampsia flexuosa, hair grass, ryegrass, reed, bluegrass, wild oat, brome, cleavers, henbit, lamium, solanum nigrum, chickweed, quackgrass, bentgrass, calamagrostis grass, field forget-grass, bermuda grass, amaranthus. Depending on crops and weeds, the amount of use varies, the usage amount of per hectare is 1~2 kg or more , such as prevention and weeding of raspberry crops and fern in forests and alpine pastures. Usage amount is 1.5~20kg/hm2.
2. Postemergent herbicide; desiccant.
Production methods
The O, O-diethyl methyl phosphonate reacted with dibromoethane reaction, heated at 80 ℃ for 2 h to get BrCH2CH2P (O) (OC2H5) CH3, and then reacted with (C2H5O2C) 2CNa (NHCOCH3) at 85 ℃to get ( C2H5O2C) 2C (NHCOCH3) CH2CH2P (O) (OC2H5) CH3, which was refluxed with hydrochloric acid, the resulting compound reacted with 28% Glufosinate-ammonium hydroxide for 8 h at 60~70 ℃ to obtain Glufosinate-ammonium.
In addition, synthesis of Glufosinate-ammonium included high-pressure catalytic synthesis method, low-temperature of targeting synthesis, using Strecker reaction and Mitchell addition process ,and so on. See "Pesticides" issue 9, 2002.
Acute toxicity
Oral-rat LD50: 1620 mg/kg; Oral-mouse LD50: 416 mg/kg.
Flammability hazard characteristics
Combustible; combustion produces toxic fumes of nitrogen oxides and sulfur oxides.
Storage characteristics
Treasury is ventilation, low-temperature and dry
Description
Glufosinate ammonium is a broad-spectrum contact killing herbicide with
the chemical formula c5h15n2o4p and the amount of chemical formula
198.16. It has the characteristics of wide herbicidal spectrum, low
toxicity, high activity and good environmental compatibility.
Chemical Properties
solid
Flammability and Explosibility
Notclassified
Agricultural Uses
Herbicide: Glufosinate-ammonium is a naturally occurring
broad-spectrum contact herbicide that is used to control
a wide range of weeds after the crop emerges or for total
vegetation control on non-crop lands. It is used on crops
that have been genetically engineered. Glufosinate herbicides are also used to desiccate crops before harvest.
Trade name
BASTA?; DERRINGER?; FINALE?;
HOE 00661?; HOE 03986?; HOE 39866?; IGNITE?;
LIBERTY?; RELY?; REMOVE?; RUBOUT?;
TOTAL?
Safety Profile
A poison by ingestion,subcutaneous, and intraperitoneal routes. Low toxicity byskin contact. Human systemic effects by ingestion: bloodpressure lowering, change in motor activity, coma,cyanosis. When heated to decomposition it emits toxicvapors of NO
Check Digit Verification of cas no
The CAS Registry Mumber 77182-82-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,1,8 and 2 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 77182-82:
(7*7)+(6*7)+(5*1)+(4*8)+(3*2)+(2*8)+(1*2)=152
152 % 10 = 2
So 77182-82-2 is a valid CAS Registry Number.
InChI:InChI=1/C5H12NO4P.H3N/c1-11(9,10)3-2-4(6)5(7)8;/h4H,2-3,6H2,1H3,(H,7,8)(H,9,10);1H3
77182-82-2Relevant articles and documents
Synthesis method of glufosinate-ammonium
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Paragraph 0038-0082, (2021/07/01)
The invention relates to the field of pesticides, in particular to a synthesis method of glufosinate-ammonium. The synthesis method of glufosinate-ammonium comprises the following steps: reacting a mixed aqueous solution of a hydantoin derivative, volatile alkali and a catalyst under 1.0-2.5 MPa, and after the reaction is finished, carrying out post-treatment to obtain glufosinate-ammonium, wherein the catalyst is a guanidine compound. The synthesis method of glufosinate-ammonium provided by the invention jumps out of the thought of separating glufosinate-ammonium from inorganic salt in the prior art, creatively adopts the mutual cooperation of volatile alkali and the catalyst (guanidine compound), and hydrolyzes the hydantoin derivative under the specific pressure of 1.0-2.5 MPa, so that the hydantoin compound is thoroughly hydrolyzed, the yield of glufosinate-ammonium is improved, meanwhile, the reaction time is shortened, acid-base neutralization is not needed after the reaction is finished, inorganic salt is not generated, generation of the inorganic salt in the glufosinate-ammonium preparation process is fundamentally eradicated, three wastes are not generated, the yield of glufosinate-ammonium is high, and industrial popularization is easy.
Process for preparing phosphorus-containing alpha-aminonitriles
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Paragraph 0096-0099, (2020/06/08)
The present invention relates primarily to processes for preparing particular phosphorus-containing α-aminonitriles of the formulae (Ia) and (Ib) defined hereinafter from corresponding phosphorus-containing cyanohydrin esters and to the use thereof for preparation of glufosinate or of glufosinate salts. The present invention further relates to a process for preparing glufosinate or glufosinate salts.
Method for synthesizing glufosinate ammonium salt
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Paragraph 0103; 0115-0116; 0123; 0135-0137; 0149-0150, (2019/11/13)
The invention discloses a method for synthesizing a glufosinate ammonium salt. The method comprises the following steps that (1) methyldiethoxyphosphine and n-butanol are used as raw materials to produce an intermediate I by hydrolysis and transesterification; (2) the intermediate I is subjected to a free radical addition reaction with acrolein cyanohydrin acetate to form an intermediate II; (3) the intermediate II is subjected to an aminolysis reaction with ammonia gas to form a mixture of an intermediate III and an intermediate IV; (4) the intermediate III and the intermediate IV are subjected to acid hydrolysis with hydrochloric acid to form an intermediate V; and (5) the intermediate V is neutralized, purified and crystallized to obtain the glufosinate ammonium salt. The method does not need to use toxic raw materials, avoids the large-scale use of ammonia water and ammonium chloride, not only greatly reduces the safety hazard, but also reduces the quantity of by-products and the amount of waste water generated, and the environmental protection risk is greatly reduced; and the purification process is simple, the product content and the yield coefficient are obviously increased,and the method is suitable for industrial scale production.
