774234-25-2

Basic information

• Product Name: 1-Boc-3-iodopyrrolidine
• Synonyms: 1-Boc-3-iodopyrrolidine;tert-butyl 3-iodopyrrolidine-1-carboxylate;1-(tert-Butoxycarbonyl)-3-iodopyrrolidine
• CAS NO: 774234-25-2
• Molecular Formula: C9H16INO2
• Molecular Weight: 297.13
• Product Categories: Intermediates
• Mol File: 774234-25-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 300.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.56±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: -3.00±0.40(Predicted)
• CAS DataBase Reference: 1-Boc-3-iodopyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-3-iodopyrrolidine(774234-25-2)
• EPA Substance Registry System: 1-Boc-3-iodopyrrolidine(774234-25-2)

Safety Data

• Hazardous Substances Data: 774234-25-2(Hazardous Substances Data)

Usage

General Description

1-Boc-3-iodopyrrolidine is a chemical compound that consists of a pyrrolidine ring with an iodine atom attached to the third carbon and a tert-butoxycarbonyl (Boc) group attached to the nitrogen atom. It is commonly used in organic synthesis as a versatile building block for the preparation of various compounds. The Boc group on the nitrogen atom can be easily removed under mild acidic conditions, allowing for further functionalization of the molecule. The iodine atom also provides a site for nucleophilic substitution reactions, making 1-Boc-3-iodopyrrolidine a valuable intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. Additionally, its stable and crystalline nature makes it easy to handle and store, further adding to its utility in chemical synthesis.

Upstream product

• 109431-87-0 (R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate 
• 103057-44-9 N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 72925-16-7 1-boc-pyrrolidine-3-carboxylic acid 
• 122684-33-7 methyl 1-tert-butoxycarbonyl-3-pyrrolidinecarboxylate 
• 51535-00-3 methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate 
• 17012-21-4 1-benzylpyrrolidine-3-carboxylic acid methyl ester 

Downstream Products

• 1263285-96-6 tert-butyl 3-(4-fluorophenyl)pyrrolidine-1-carboxylate 
• 147410-43-3 tert-butyl 3-phenylpyrrolidine-1-carboxylate 
• 874218-24-3 tert-butyl 3-(pyridin-3-yl)pyrrolidine-1-carboxylate 

Relevant articles and documents

Copper-Catalyzed Cross-Coupling between Alkyl (Pseudo)halides and Bicyclopentyl Grignard Reagents

The development of a copper-catalyzed cross-coupling between primary and secondary (pseudo)halides and bicyclopentyl Grignard reagents is reported. Highly strained bicyclopentanes can be cross-coupled with a large panel of primary alkyl mesylates and secondary alkyl iodides. The catalytic system is simple and cheap, and the reaction is general and chemoselective.

[1,2,4]-TRIAZOLO [1,5-A]-PYRIMIDINYL DERIVATIVES SUBSTITUTED WITH PIPERIDINE, MORPHOLINE OR PIPERAZINE AS OGA INHIBITORS

The present invention relates to O-GlcNAc hydrolase (OGA) inhibitors. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which inhibition of OGA is beneficial, such as tauopathies, in particular Alzheimer's disease or progressive supranuclear palsy; and neurodegenerative diseases accompanied by a tau pathology, in particular amyotrophic lateral sclerosis or frontotemporal lobe dementia caused by C90RF72 mutations.

ALKENYL NAPHTHYLACETIC ACIDS

The invention is concerned with the compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.