775-33-7

Basic information

• Product Name: N,N-dimethyl-4-methoxyphenylethylamine
• Synonyms: N,N-dimethyl-4-methoxyphenylethylamine;Des(1-cyclohexanol) Venlafaxine;Venlafaxine iMpurity A (EP) as Hydrochloride;4-Methoxy-N,N-diMethylbenzeneethanaMine;N,N-DiMethyl-2-(p-anisyl)ethylaMine;N,N-DiMethyl-4-MethoxyphenethylaMine;p-Methoxy-N,N-diMethyl- phenethylaMine;IMp. A (EP) as Hydrochloride: 2-(4-Methoxyphenyl)-N,N-diMethylethanaMine Hydrochloride
• CAS NO: 775-33-7
• Molecular Formula: C₁₁H₁₇NO
• Molecular Weight: 179.26
• Product Categories: Amiines;Aromatics;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 775-33-7.mol
• Article Data: 14

Chemical Properties

• Melting Point: 115-117 °C
• Boiling Point: 254.9°C at 760 mmHg
• Flash Point: 74.5°C
• Appearance: /
• Density: 0.961g/cm³
• Vapor Pressure: 0.0168mmHg at 25°C
• Refractive Index: 1.506
• Storage Temp.: Refrigerator
• Solubility: Acetonitrile (Very Slightly), Chloroform (Slightly)
• PKA: 9.57±0.22(Predicted)
• CAS DataBase Reference: N,N-dimethyl-4-methoxyphenylethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-4-methoxyphenylethylamine(775-33-7)
• EPA Substance Registry System: N,N-dimethyl-4-methoxyphenylethylamine(775-33-7)

Safety Data

• Hazardous Substances Data: 775-33-7(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Oil

Uses

Different sources of media describe the Uses of 775-33-7 differently. You can refer to the following data:
1. Des(1-cyclohexanol) Venlafaxine (Venlafaxine EP Impurity A) is a Venlafaxine (V119995) impurity.
2. Venlafaxine (V119995) impurity.

InChI:InChI=1/C11H17NO/c1-12(2)9-8-10-4-6-11(13-3)7-5-10/h4-7H,8-9H2,1-3H3

Upstream product

• 67-56-1 methanol 
• 104-47-2 p-methoxybenzylnitrile 
• 124-40-3 dimethyl amine 
• 93413-76-4 1-[cyano(4-methoxyphenyl)methyl]cyclohexanol 
• 31236-71-2 lysichitalexin 
• 50-00-0 formaldehyd 
• 55-81-2 4-Methoxyphenethylamine 
• 702-23-8 2-(4-Methoxyphenyl)ethanol 
• 104-01-8 4-Methoxyphenylacetic acid 
• 19625-79-7 N,N-dimethyl-2-(4-methoxyphenyl)ethanamide 
• 126062-57-5 dimethyl(4-methoxybenzyl)<(trimethylsilyl)methyl>ammonium iodide 
• 18217-00-0 1-(2-Chloroethyl)-4-methoxybenzene 
• 76579-52-7 N,N-dimethyl(4-methoxyphenyl)thioacetamide 

Downstream Products

• 34875-26-8 (2-(p-methoxyphenyl)ethyl)dimethylamine N-oxide 
• 637-69-4 4-Methoxystyrene 
• 82966-18-5 1-(4-methoxyphenethyl)-piperidine 
• 27946-67-4 (4-methoxyphenethyl)trimethylammonium iodide 
• 3761-58-8 candicine chloride 
• 103847-04-7 {2-[3-(6-{(E)-2-[5-(2-Dimethylamino-ethyl)-2-methoxy-phenyl]-vinyl}-3,6-dimethyl-cyclohex-2-enyl)-4-methoxy-phenyl]-ethyl}-dimethyl-amine 
• 103805-67-0 alloculantraraminol 
• 103805-67-0 5-epiculantraraminol 
• 103805-67-0 culantraminol 
• 103823-32-1 culantraramine 
• 103847-08-1 4-(2'-methoxyhordeninyl)-(E)-but-3-en-2-one 
• 103847-07-0 4-(2'-methoxyhordeninyl)-(E)-2-methylbut-3-en-2-ol 
• 103847-09-2 1-(2'-methoxyhordeninyl)-3-methyl-1,3-butadiene 
• 103847-05-8 2-formylmethoxyhordenine 

Relevant articles and documents

Dimethylamination of Primary Alcohols Using a Homogeneous Iridium Catalyst: A Synthetic Method for N, N-Dimethylamine Derivatives

A new catalytic system for N,N-dimethylamination of primary alcohols using aqueous dimethylamine in the absence of additional organic solvents has been developed. The reaction proceeds via borrowing hydrogen processes, which are atom-efficient and environmentally benign. An iridium catalyst bearing an N-heterocyclic carbene (NHC) ligand exhibited high performance, without showing any deactivation under aqueous conditions. In addition, valuable N,N-dimethylamine derivatives, including biologically active and pharmaceutical molecules, were synthesized. The practical application of this methodology was demonstrated by a gram-scale reaction.

Reductive N-methylation of amines with calcium hydride and Pd/C catalyst

The methylation of amines by paraformaldehyde in the presence of calcium hydride as a source of hydrogen and palladium on charcoal as catalyst was studied. Depending on the quantity of paraformaldehyde, monomethylated and dimethylated amines were selectively and efficiently prepared in one pot with good yields.

Impurity profile study of venlafaxine hydrochloride, an antipsychotic drug substance

Venlafaxine hydrochloride is a phenyl ethylamine derivative, used for the treatment of depression. During the process development of venlafaxine hydrochloride, six process-related potential impurities were detected in high-performance liquid chromatograph