77542-06-4 Usage
General Description
1-[4-(2-dimethylamino-ethoxy)phenyl]-1,2-diphenyl-1-butanol is a chemical compound with the molecular formula C28H33NO2. It is a white solid with a molecular weight of 411.57 g/mol. 1-[4-(2-DIMETHYLAMINO-ETHOXY)PHENYL]-1,2-DIPHENYL-1-BUTANOL is a substituted diphenylbutanol, with a dimethylamino-ethoxy group attached to one of the phenyl rings. It is used in pharmaceutical research as a potential drug candidate for various medical conditions, including cancer and cardiovascular diseases. The compound's structure and properties make it suitable for studying its pharmacological effects and potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 77542-06-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,5,4 and 2 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 77542-06:
(7*7)+(6*7)+(5*5)+(4*4)+(3*2)+(2*0)+(1*6)=144
144 % 10 = 4
So 77542-06-4 is a valid CAS Registry Number.
77542-06-4Relevant articles and documents
Stereoselective Olefin Formation from the Dehydration of 1-(p-Alkoxyphenyl)-1,2-diphenylbutan-1-ols: Application to the Synthesis of Tamoxifen
McCague, Raymond
, p. 1011 - 1016 (2007/10/02)
Acid-catalysed dehydration of either diastereoisomer of a 1-(p-alkoxyphenyl)-1,2-diphenylbutan-1-ol gives mainly the Z isomer of the but-1-ene via a common carbenium ion intermediate that can be regenerated by protonation of the (Z)- or (E)-butene with fluorosulphonic acid.Highly stereoselective syn eliminations were achieved by treatment of the butan-1-ols with base and carbon disulphide but dehydrations using N,N,N-triethylammonio-N'-methoxycarbonylsulphamidate proceeded mainly via a carbenium ion.Aspects of the stereoselectivity of the reactions are discussed.The methods can be applied to give simple stereoselective syntheses of the anti-cancer drug tamoxifen.
