77671-29-5

Basic information

• Product Name: 4-(4-methoxybenzoyl)-5-methyl-1,3-dihydro-2H-imidazol-2-one
• Synonyms: (2-hydroxy-4-methyl-1H-imidazol-5-yl)(4-methoxyphenyl)methanone; 2H-Imidazol-2-one, 1,3-dihydro-4-(4-methoxybenzoyl)-5-methyl-; methanone, (2-hydroxy-4-methyl-1H-imidazol-5-yl)(4-methoxyphenyl)-
• CAS NO: 77671-29-5
• Molecular Formula: C₁₂H₁₂N₂O₃
• Molecular Weight: 232.2353
• Mol File: 77671-29-5.mol
• Article Data: 3

Chemical Properties

• Density: 1.238g/cm³
• Refractive Index: 1.567
• CAS DataBase Reference: 4-(4-methoxybenzoyl)-5-methyl-1,3-dihydro-2H-imidazol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methoxybenzoyl)-5-methyl-1,3-dihydro-2H-imidazol-2-one(77671-29-5)
• EPA Substance Registry System: 4-(4-methoxybenzoyl)-5-methyl-1,3-dihydro-2H-imidazol-2-one(77671-29-5)

Safety Data

• Hazardous Substances Data: 77671-29-5(Hazardous Substances Data)

Upstream product

• 1192-34-3 4-methyl-1,3-dihydro-imidazol-2-one 
• 100-07-2 4-methoxy-benzoyl chloride 
• 100-09-4 4-methoxybenzoic acid 

Downstream Products

• 77671-30-8 1,3-dihydro-4-(4-hydroxybenzoyl)-5-methyl-2H-imidazol-2-one 
• 77671-38-6 1,3-dihydro-4-(4-methoxybenzoyl)-1,3,5-trimethyl-2H-imidazol-2-one 
• 85473-96-7 4-(4-Methoxy-benzoyl)-1,5-dimethyl-1,3-dihydro-imidazol-2-one 
• 77698-16-9 5-(4-Methoxy-benzoyl)-1,4-dimethyl-1,3-dihydro-imidazol-2-one 

Relevant articles and documents

Preparation and evaluation of some anti-arrhythmic and cardiac inotropic agents as 'cold' analogs of potential myocardial imaging agents

The iodinated anti-arrhythmic analogs of disopyramide (1), procainamide (2) and lidocaine (3) and a new class of imidazolone cardiac inotropic phosphodiesterase inhibitors (4) and (5) (enoximone analogs), were prepared and tested as potential myocardial imaging agents. Compounds 1 and 2 were prepared by direct iodination using iodine monochloride in acetic acid, while 3-5 were prepared from suitable starting materials. The tissue load of the iodinated compounds was determined, in rats, on the basis of their iodine content using adaptation of a recent modification of Sandell and Kolthoff assay. The biodistribution of 125I-iodo derivatives of 2 and 4 were performed in mice. A pharmacokinetic study was performed using 5 to determine the optimal time of imaging post-injection. These compounds have shown significant localization in the heart tissue.

4-Aroyl-1,3-dihydro-2H-imidazol-2-ones, a new class of cardiotonic agents

A series of 4-aroyl-1,3-dihydro-2H-imidazol-2-ones was synthesized and evaluated for pharmacological activity in the anesthetized dog. Most members of this series produced dose-related increases in cardiac contractile force as well as relatively minor inc