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1192-34-3

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1192-34-3 Usage

Description

1,3-Dihydro-4-methyl-2H-imidazol-2-one, also known as 4-Methyl-4-imidazolin-2-one, is a chemical compound that shares structural similarities with uric acid. It is recognized for its potential as an antioxidant and free radical scavenger, which can be significant in human health and various applications.

Uses

Used in Pharmaceutical Industry:
1,3-Dihydro-4-methyl-2H-imidazol-2-one is used as a pharmaceutical agent for its antioxidant and free radical scavenging properties. It plays a crucial role in protecting the body from oxidative stress and damage caused by reactive oxygen species, which can lead to various diseases and conditions.
Used in Cosmetics Industry:
In the cosmetics industry, 1,3-Dihydro-4-methyl-2H-imidazol-2-one is used as an ingredient in skincare and beauty products due to its antioxidant capabilities. It helps in neutralizing free radicals that can cause skin damage, premature aging, and other skin-related issues.
Used in Food and Beverage Industry:
1,3-Dihydro-4-methyl-2H-imidazol-2-one is also utilized in the food and beverage industry as an additive to enhance the shelf life and quality of products. Its antioxidant properties help in preventing oxidation and spoilage, maintaining the freshness and taste of the products.
Used in Research and Development:
1,3-Dihydro-4-methyl-2H-imidazol-2-one is used in research and development for studying its potential applications in various fields, including medicine, pharmacology, and biotechnology. Its antioxidant and free radical scavenging properties make it a valuable subject for scientific investigation and the development of new therapeutic strategies.

Check Digit Verification of cas no

The CAS Registry Mumber 1192-34-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,9 and 2 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1192-34:
(6*1)+(5*1)+(4*9)+(3*2)+(2*3)+(1*4)=63
63 % 10 = 3
So 1192-34-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H6N2O/c1-3-2-5-4(7)6-3/h2H,1H3,(H2,5,6,7)

1192-34-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-methyl-1,3-dihydroimidazol-2-one

1.2 Other means of identification

Product number -
Other names 4-methyl-1,3-dihydro-2H-imidazol-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1192-34-3 SDS

1192-34-3Synthetic route

isopropyl alcohol
67-63-0

isopropyl alcohol

4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

Conditions
ConditionsYield
With hydrogenchloride; sodium hydrogencarbonate; sodium carbonate In methanol; ethanol; chloroform72%
cyanic acid
420-05-3

cyanic acid

glycine methyl ketone
298-08-8

glycine methyl ketone

4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

Conditions
ConditionsYield
With hydrogenchloride56%
3-acetonyl-2,4-thiazolidinedione
88419-03-8

3-acetonyl-2,4-thiazolidinedione

4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

Conditions
ConditionsYield
With ammonium hydroxide for 4h; Heating;41%
5-methyl-2-oxo-2,3-dihydro-1H-imidazole-4-carboxylic acid ethyl ester
82831-19-4

5-methyl-2-oxo-2,3-dihydro-1H-imidazole-4-carboxylic acid ethyl ester

4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

Conditions
ConditionsYield
With barium dihydroxide
With barium dihydroxide Decarboxylation; hydrolysis; Heating;
(Z)-2-oxopropanal oxime
31915-82-9

(Z)-2-oxopropanal oxime

4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

Conditions
ConditionsYield
With hydrogenchloride; palladium on activated charcoal under 36775.4 Torr; Erwaermen des Reaktionsgemisches mit Kaliumcyanat;
DL-alanine ethyl ester hydrochloride

DL-alanine ethyl ester hydrochloride

4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

Conditions
ConditionsYield
With hydrogenchloride; sodium amalgam Behandeln des Reaktionsgemisches mit NaHCO3 und Kaliumcyanat;
4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

4-methoxy-phenyl-sulphonyl chloride
98-68-0

4-methoxy-phenyl-sulphonyl chloride

1-(4-Methoxy-benzenesulfonyl)-4-methyl-1,3-dihydro-imidazol-2-one
83735-99-3

1-(4-Methoxy-benzenesulfonyl)-4-methyl-1,3-dihydro-imidazol-2-one

Conditions
ConditionsYield
In pyridine90%
4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

1-chlorooct-1-en-3-one
2656-70-4

1-chlorooct-1-en-3-one

4-methyl-5-n-amylketovinyl-2-imidazolinone
76064-01-2

4-methyl-5-n-amylketovinyl-2-imidazolinone

Conditions
ConditionsYield
With aluminium trichloride In nitrobenzene 20 deg C, 1 h -> 42-46 deg C, 16 h;89%
4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

1-benzoyl-2-chloroethene
3306-07-8

1-benzoyl-2-chloroethene

4-methyl-5-phenylketovinyl-2-imidazolinone
76064-03-4

4-methyl-5-phenylketovinyl-2-imidazolinone

Conditions
ConditionsYield
With aluminium trichloride In nitrobenzene 20 deg C, 2 h -> 45-50 deg C, 15 h;88%
4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

4–(1,3-dioxoisoindolin-2-yl)benzoyl chloride
5383-83-5

4–(1,3-dioxoisoindolin-2-yl)benzoyl chloride

1,3-Dihydro-5-methyl-4-(4-phthalimidobenzoyl)-3H-imidazol-2-one
173375-21-8

1,3-Dihydro-5-methyl-4-(4-phthalimidobenzoyl)-3H-imidazol-2-one

Conditions
ConditionsYield
With aluminium trichloride In nitrobenzene at 60℃; for 6h;88%
4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

4-Fluorobenzenesulfonyl chloride
349-88-2

4-Fluorobenzenesulfonyl chloride

1-(4-Fluoro-benzenesulfonyl)-4-methyl-1,3-dihydro-imidazol-2-one
83736-00-9

1-(4-Fluoro-benzenesulfonyl)-4-methyl-1,3-dihydro-imidazol-2-one

Conditions
ConditionsYield
In pyridine87%
4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

benzoyl chloride
98-88-4

benzoyl chloride

4-benzoyl-5-methyl-1H-imidazol-2(3H)-one
75237-40-0

4-benzoyl-5-methyl-1H-imidazol-2(3H)-one

Conditions
ConditionsYield
With aluminium trichloride In nitrobenzene at 60℃; for 6h;85%
With aluminium trichloride In nitrobenzene at 60 - 65℃; for 6h;67%
With aluminium trichloride; nitrobenzene
4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

4-Methyl-5-(4-nitro-benzoyl)-1,3-dihydro-imidazol-2-one

4-Methyl-5-(4-nitro-benzoyl)-1,3-dihydro-imidazol-2-one

Conditions
ConditionsYield
With aluminium trichloride In nitrobenzene at 60℃; for 6h;85%
4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

Conditions
ConditionsYield
In pyridine80%
4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

Conditions
ConditionsYield
In pyridine80%
Conditions
ConditionsYield
With dihydrogen peroxide In methanol; ethanol for 6h; Ambient temperature;80%
4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

2,5-dibromobenzenesulfonyl chloride
23886-64-8

2,5-dibromobenzenesulfonyl chloride

Conditions
ConditionsYield
In pyridine75%
4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

Conditions
ConditionsYield
With aluminium trichloride In nitrobenzene at 60℃; for 6h;63%
With aluminium trichloride In nitrobenzene at 60 - 65℃; for 6h;20%
aluminium trichloride In nitrobenzene
aluminium trichloride In N-methyl-acetamide; nitrobenzene
4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

2,5-dichlorobenzenesulphonyl chloride
5402-73-3

2,5-dichlorobenzenesulphonyl chloride

1-(2,5-Dichloro-benzenesulfonyl)-4-methyl-1,3-dihydro-imidazol-2-one
83736-01-0

1-(2,5-Dichloro-benzenesulfonyl)-4-methyl-1,3-dihydro-imidazol-2-one

Conditions
ConditionsYield
In pyridine56%
4-methyl-1,3-dihydro-imidazol-2-one

4-methyl-1,3-dihydro-imidazol-2-one

4-chloro-benzoyl chloride
122-01-0

4-chloro-benzoyl chloride

Conditions
ConditionsYield
With aluminium trichloride In nitrobenzene at 60 - 65℃; for 6h;51%
trans-chrotonyl chloride
625-35-4, 3488-22-0, 10487-71-5

trans-chrotonyl chloride

4-methyl-5-crotonyl-2-imidazolinone
76588-59-5

4-methyl-5-crotonyl-2-imidazolinone

Conditions
ConditionsYield
With aluminium trichloride In nitrobenzene 20 deg C, 1 h -> 45 deg C, 13 h;44%
4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

3-iodo-4-methylbenzoyl chloride
52107-98-9

3-iodo-4-methylbenzoyl chloride

1,3-dihydro-4-(3-iodo-4-methylbenzoyl)-5-methyl-2H-1,3-imidazol-2-one
213594-71-9

1,3-dihydro-4-(3-iodo-4-methylbenzoyl)-5-methyl-2H-1,3-imidazol-2-one

Conditions
ConditionsYield
With aluminium trichloride In nitrobenzene Acylation;42%
4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

2-Methoxybenzoyl chloride
21615-34-9

2-Methoxybenzoyl chloride

1,3-dihydro-4-(2-hydroxybenzoyl)-5-methyl-2H-imidazol-2-one
83167-13-9

1,3-dihydro-4-(2-hydroxybenzoyl)-5-methyl-2H-imidazol-2-one

Conditions
ConditionsYield
With aluminium trichloride In nitrobenzene at 60 - 65℃; for 6h;41%
2-furancarbonyl chloride
527-69-5

2-furancarbonyl chloride

4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

1,3-dihydro-4-(2-furanoyl)-5-methyl-2H-imidazol-2-one
77671-34-2

1,3-dihydro-4-(2-furanoyl)-5-methyl-2H-imidazol-2-one

Conditions
ConditionsYield
With aluminium trichloride In nitrobenzene at 60 - 65℃; for 6h;34%
aluminium trichloride In nitrobenzene
4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

3,4-dimethoxybenzoic acid chloride
3535-37-3

3,4-dimethoxybenzoic acid chloride

1,3-dihydro-4-(3,4-dimethoxybenzoyl)-5-methyl-2H-imidazol-2-one
82709-62-4

1,3-dihydro-4-(3,4-dimethoxybenzoyl)-5-methyl-2H-imidazol-2-one

Conditions
ConditionsYield
With aluminium trichloride In nitrobenzene at 60 - 65℃; for 6h;32%
4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

4-methoxy-benzoyl chloride
100-07-2

4-methoxy-benzoyl chloride

1,3-dihydro-4-(4-methoxybenzoyl)-5-methyl-2H-imidazol-2-one
77671-29-5

1,3-dihydro-4-(4-methoxybenzoyl)-5-methyl-2H-imidazol-2-one

Conditions
ConditionsYield
With aluminium trichloride In nitrobenzene Acylation;30%
With aluminium trichloride In nitrobenzene at 60 - 65℃; for 6h;26%
4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

o-chlorobenzoyl chloride
609-65-4

o-chlorobenzoyl chloride

4-(2-chlorobenzoyl)-1,3-dihydro-5-methyl-2H-imidazol-2-one
83167-11-7

4-(2-chlorobenzoyl)-1,3-dihydro-5-methyl-2H-imidazol-2-one

Conditions
ConditionsYield
With aluminium trichloride In nitrobenzene at 60 - 65℃; for 6h;29%
4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

3,4-dichlorobenzoyl chloride
3024-72-4

3,4-dichlorobenzoyl chloride

4-(3,4-Dichloro-benzoyl)-5-methyl-1,3-dihydro-imidazol-2-one
83167-12-8

4-(3,4-Dichloro-benzoyl)-5-methyl-1,3-dihydro-imidazol-2-one

Conditions
ConditionsYield
With aluminium trichloride In nitrobenzene at 60 - 65℃; for 6h;21%
2-Thiophenecarbonyl chloride
5271-67-0

2-Thiophenecarbonyl chloride

4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

1,3-dihydro-4-methyl-5-(2-thienoyl)-2H-imidazol-2-one
77671-33-1

1,3-dihydro-4-methyl-5-(2-thienoyl)-2H-imidazol-2-one

Conditions
ConditionsYield
With aluminium trichloride In nitrobenzene at 60 - 65℃; for 6h;16%
4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

4-hydroxybenzoyl chloride
28141-24-4

4-hydroxybenzoyl chloride

1,3-dihydro-4-(4-hydroxybenzoyl)-5-methyl-2H-imidazol-2-one
77671-30-8

1,3-dihydro-4-(4-hydroxybenzoyl)-5-methyl-2H-imidazol-2-one

Conditions
ConditionsYield
With aluminium trichloride In nitrobenzene at 60 - 65℃; for 6h;12%
ethyl 6-chloro-6-oxohexanoate
1071-71-2

ethyl 6-chloro-6-oxohexanoate

4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

ethyl 6-(5-methyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-6-oxohexanoate
39215-52-6

ethyl 6-(5-methyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-6-oxohexanoate

Conditions
ConditionsYield
With aluminium trichloride; nitrobenzene
4-methyl-1,3-dihydro-imidazol-2-one
1192-34-3

4-methyl-1,3-dihydro-imidazol-2-one

Acetyl bromide
506-96-7

Acetyl bromide

4-acetyl-5-methyl-1,3-dihydro-imidazol-2-one
53064-61-2

4-acetyl-5-methyl-1,3-dihydro-imidazol-2-one

Conditions
ConditionsYield
With aluminium trichloride; nitrobenzene

1192-34-3Relevant articles and documents

Preparation and evaluation of some anti-arrhythmic and cardiac inotropic agents as 'cold' analogs of potential myocardial imaging agents

El-Moselhy, Tarek F.,El-Kersh, Mohamed A.,Nyberg, Fred,Hede, Ragnar,Eldawy, Mohamed A.

, p. 163 - 170 (2007/10/03)

The iodinated anti-arrhythmic analogs of disopyramide (1), procainamide (2) and lidocaine (3) and a new class of imidazolone cardiac inotropic phosphodiesterase inhibitors (4) and (5) (enoximone analogs), were prepared and tested as potential myocardial imaging agents. Compounds 1 and 2 were prepared by direct iodination using iodine monochloride in acetic acid, while 3-5 were prepared from suitable starting materials. The tissue load of the iodinated compounds was determined, in rats, on the basis of their iodine content using adaptation of a recent modification of Sandell and Kolthoff assay. The biodistribution of 125I-iodo derivatives of 2 and 4 were performed in mice. A pharmacokinetic study was performed using 5 to determine the optimal time of imaging post-injection. These compounds have shown significant localization in the heart tissue.

Process for the production of 2-imidazolones

-

, (2008/06/13)

The present invention pertains to a process for producing a 2-imidazolone from a ureidoacetal. The ureidoacetal is subjected to an acid catalyzed condensation in order to produce the 2-imidazolone. The reaction is conducted in an alcoholic solvent in order to minimize the production of a polymeric by-product.

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