77771-03-0

Basic information

• Product Name: 3-Bromo-4-fluorobenzylamine hydrochloride
• Synonyms: 3-Bromo-4-fluorobenzyl alcohol 99%;RARECHEM AL BD 0277;3-BROMO-4-FLUOROBENZYL ALCOHOL;(3-BROMO-4-FLUORO-PHENYL)-METHANOL;3-BROMO-4-FLUOROBENZYLAMINE HYDROCHLORIDE 98%;3-Bromo-4-fluorobenzylamine hydrochloride;3-Bromo-4-fluorobenzylamine hydrochloride,98%
• CAS NO: 77771-03-0
• Molecular Formula: C₇H₆BrFO
• Molecular Weight: 240.5
• Product Categories: Benzhydrols, Benzyl & Special Alcohols;Anilines, Aromatic Amines and Nitro Compounds;Alcohols;Bromine Compounds;Fluorine Compounds;Anilines, Amides & Amines;Fluorine series
• Mol File: 77771-03-0.mol
• Article Data: 13

Chemical Properties

• Melting Point: 214 °C
• Boiling Point: 80°C/0.5mm
• Flash Point: 105.3 °C
• Appearance: Yellow/Powder
• Density: 1.658±0.06 g/cm3(Predicted)
• Vapor Pressure: 0.0216mmHg at 25°C
• Refractive Index: 1.5590 to 1.5630
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.83±0.10(Predicted)
• Water Solubility: soluble
• CAS DataBase Reference: 3-Bromo-4-fluorobenzylamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-4-fluorobenzylamine hydrochloride(77771-03-0)
• EPA Substance Registry System: 3-Bromo-4-fluorobenzylamine hydrochloride(77771-03-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25
• Hazardous Substances Data: 77771-03-0(Hazardous Substances Data)

Usage

Chemical Properties

YELLOW POWDER

InChI:InChI:1S/C7H7BrFN.ClH/c8-6-3-5(4-10)1-2-7(6)9;/h1-3H,4,10H2;1H

Upstream product

• 1634-04-4 tert-butyl methyl ether 
• 1007-16-5 3-bromo-4-fluorobenzoic acid 
• 79-22-1 methyl chloroformate 
• 16940-66-2 sodium tetrahydroborate 
• 78239-65-3 3-bromo-4-fluoro-benzoic acid fluoride 
• 206551-41-9 2-fluoro-3-bromobenzoic acid methyl ester 
• 82702-31-6 methyl 3-bromo-4-fluorobenzoate 
• 103-83-3 N,N'-dimethylbenzylamine 
• 5197-95-5 benzyltriethylammonium bromide 
• 541-41-3 chloroformic acid ethyl ester 
• 77771-02-9 3-bromo-4-fluorobenzaldehyde 

Downstream Products

• 1248085-09-7 C₁₀H₁₂BrFO₂ 
• 866862-23-9 3-bromo-4-fluorobenzyl metanesulfonate 
• 1120371-01-8 (E)-1-(3-bromo-4-fluorophenyl)-2-methylbut-2-en-1-ol 
• 1609540-78-4 5-(((tert-butyldimethylsilyl)oxy)methyl)-2-fluorobenzoic acid 
• 1609540-85-3 5-(((tert-butyldimethylsilyl)oxy)methyl)-2-fluorobenzaldehyde 
• 1609540-89-7 tert-butyl((4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)dimethylsilane 

Relevant articles and documents

Bromine structural domain inhibitor compound and application thereof

The invention relates to a bromine structural domain inhibitor and provides a compound shown in a general formula I, pharmaceutical salt, an enantiomer, a diastereoisomer, an atropisomer, racemate, apolymorphic substance and solvate of the compound or an isotope labelled compound (including a deuterium substituted compound), a preparation method of the compound, pharmaceutical composition containing the compound and an application of the above components in pharmaceuticals.

Synthesis of structurally diverse diarylketones through the diarylmethyl sp3 C-H oxidation

Under open-flask conditions, an efficient method to assemble a series of diversely functionalized diarylketones in the presence of commercially available NBS has been developed. Yields of up to 99% have been achieved employing diarylmethanes as starting material. Based on 18O-labeled experiment, the addition of stoichiometric water eventually leads to excellent yields in all carbonylation cases.

METHOD FOR PRODUCING PRECURSORS FOR L-2- [18F] FLUOROPHENYLALANINE AND 6- [18F] FLUORO-L--META-TYROSINE AND THE ALPHA-METHYLATED DERIVATIVES THEREOF, PRECURSOR, AND METHOD FOR PRODUCING L-2- [18F] FLUOROPHENYLALANINE AND 6- [18F] FLUORO-L-META-TYROSINE AN

Disclosed is a method for producing precursors for 2-[18F]fluorophenylalanine and 6-[18F]fluoro-L-meta-tyrosine and the α-methylated derivatives thereof, to the precursor, and to a method for producing 2-[18F]fluorophenyla