783-08-4Relevant articles and documents
Controlling Proton-Coupled Electron Transfer in Bioinspired Artificial Photosynthetic Relays
Odella, Emmanuel,Mora, S. Jimena,Wadsworth, Brian L.,Huynh, Mioy T.,Goings, Joshua J.,Liddell, Paul A.,Groy, Thomas L.,Gervaldo, Miguel,Sereno, Leónides E.,Gust, Devens,Moore, Thomas A.,Moore, Gary F.,Hammes-Schiffer, Sharon,Moore, Ana L.
, p. 15450 - 15460 (2018)
Bioinspired constructs consisting of benzimidazole-phenol moieties bearing N-phenylimines as proton-accepting substituents have been designed to mimic the H-bond network associated with the TyrZ-His190 redox relay in photosystem II. These compo
Redox-Neutral Imination of Alcohol with Azide: A Sustainable Alternative to the Staudinger/Aza-Wittig Reaction
Li, Huaifeng,Lupp, Daniel,Das, Pradip K.,Yang, Li,Gon?alves, Théo P.,Huang, Mei-Hui,El Hajoui, Marwa,Liang, Lan-Chang,Huang, Kuo-Wei
, p. 4071 - 4076 (2021/04/12)
The traditional Staudinger/aza-Wittig reaction represents one of the most powerful tools for imine formation. However, for this multistep procedure, the sacrificial phosphine has to be used, resulting in difficulties in the purification process and waste disposal at the same time. Here, we report a redox-neutral azide-alcohol imination methodology enabled by a base-metal nickel PN3 pincer catalyst. The one-step, waste-free, and high atom-economical features highlight its advantages further. Moreover, mechanistic insight suggests a non-metal-ligand cooperation pathway based on the observation of an intermediate and density functional theory calculations.
Azetidinimines as a novel series of non-covalent broad-spectrum inhibitors of β-lactamases with submicromolar activities against carbapenemases KPC-2 (class A), NDM-1 (class B) and OXA-48 (class D)
Romero, Eugénie,Oueslati, Saoussen,Benchekroun, Mohamed,D'Hollander, Agathe C.A.,Ventre, Sandrine,Vijayakumar, Kamsana,Minard, Corinne,Exilie, Cynthia,Tlili, Linda,Retailleau, Pascal,Zavala, Agustin,Elisée, Eddy,Selwa, Edithe,Nguyen, Laetitia A.,Pruvost, Alain,Naas, Thierry,Iorga, Bogdan I.,Dodd, Robert H.,Cariou, Kevin
supporting information, (2021/04/19)
The occurrence of resistances in Gram negative bacteria is steadily increasing to reach extremely worrying levels and one of the main causes of resistance is the massive spread of very efficient β-lactamases which render most β-lactam antibiotics useless. Herein, we report the development of a series of imino-analogues of β-lactams (namely azetidinimines) as efficient non-covalent inhibitors of β-lactamases. Despite the structural and mechanistic differences between serine-β-lactamases KPC-2 and OXA-48 and metallo-β-lactamase NDM-1, all three enzymes can be inhibited at a submicromolar level by compound 7dfm, which can also repotentiate imipenem against a resistant strain of Escherichia coli expressing NDM-1. We show that 7dfm can efficiently inhibit not only the three main clinically-relevant carbapenemases of Ambler classes A (KPC-2), B (NDM-1) and D (OXA-48) with Ki's below 0.3 μM, but also the cephalosporinase CMY-2 (class C, 86% inhibition at 10 μM). Our results pave the way for the development of a new structurally original family of non-covalent broad-spectrum inhibitors of β-lactamases.