78761-25-8

Basic information

• Product Name: D-(-)-O,N-Diacetyl-α-phenylglycinol
• Synonyms: D-(-)-O,N-Diacetyl-α-phenylglycinol
• CAS NO: 78761-25-8
• Molecular Weight: 221.256
• Mol File: 78761-25-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: D-(-)-O,N-Diacetyl-α-phenylglycinol(CAS DataBase Reference)
• NIST Chemistry Reference: D-(-)-O,N-Diacetyl-α-phenylglycinol(78761-25-8)
• EPA Substance Registry System: D-(-)-O,N-Diacetyl-α-phenylglycinol(78761-25-8)

Safety Data

• Hazardous Substances Data: 78761-25-8(Hazardous Substances Data)

Upstream product

• 463-51-4 Ketene 
• 56613-80-0 D-2-phenylglycinol 
• 56613-80-0 D-(-)-2-amino-2-phenyl-1-ethanol 
• 64-19-7 acetic acid 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 875-74-1 (R)-phenylglycine 

Downstream Products

• 78761-26-9 N-[(1R)-2-hydroxy-1-phenylethyl]acetamide 
• 87319-88-8 (S)-3-Hydroxy-4-methyl-pentanoic acid ((R)-2-hydroxy-1-phenyl-ethyl)-amide 
• 87319-84-4 (1'R,3R)-3-Hydroxy-N-(2-hydroxy-1-phenylethyl)-4-methylpentanamid 
• 87319-89-9 (R)-3-Hydroxy-hexanoic acid ((R)-2-hydroxy-1-phenyl-ethyl)-amide 
• 87319-85-5 (1'R,3S)-3-Hydroxy-N-(2-hydroxy-1-phenylethyl)-hexanamid 
• 87319-83-3 (1'R,3R)-3-Hydroxy-N-(2-hydroxy-1-phenylethyl)-4,4-dimethylpentanamid 
• 87319-87-7 (S)-3-Hydroxy-4,4-dimethyl-pentanoic acid ((R)-2-hydroxy-1-phenyl-ethyl)-amide 
• 87336-56-9 (R)-3-Hydroxy-N-((R)-2-hydroxy-1-phenyl-ethyl)-3-phenyl-butyramide 
• 87336-57-0 (S)-3-Hydroxy-N-((R)-2-hydroxy-1-phenyl-ethyl)-3-phenyl-butyramide 
• 33911-77-2 (R)-2-phenyl-N-acetylaziridine 

Relevant articles and documents

Method using amide ester to prepare diamine derivative

The invention provides a method using amide ester to prepare a diamine derivative. The method is characterized in that ester groups in amide esters containing both amide and ester functional groups are substituted to prepare the diamine derivative, and one of the diamine groups of the diamine derivative is carboxylic acid amide reserved from the amide ester raw materials. The method is cheap in raw material, easy in raw material obtaining, low in catalyst use amount, simple in reaction conditions and high in product stereoselectivity.

MUSCARINIC AGONISTS

The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor.

On Amino Acid Antagonists,IV.-Separation and Determination of the Configurations of the Stereoisomeric N-Acetyl-2-(2'-cyclohexenyl)glycines

The D-(+)-(1-phenylethyl)amides 5 as well as the D-(-)-O-acetyl-α-phenylglycinolamides 7 of the title compounds were separated on silica gel into the four diastereomeric compounds.All attempts failed to hydrolyze 5 and 7 to the corresponding acids.In contrast the diastereomeric D-(-)-N-acetyl-α-phenylglycinol esters 10 which were separated on silica gel were hydrolysed to the optically active acids 3a-d.The absolute configurations at C-2 in 3 were determined by correlation with the saturated glycine derivatives of known stereochemistry.The relative configurationsand hence the absolute configurations at C-1' in 3a-d were deduced from the NMR- and CD-spectra and were confirmed by X-ray analysis of 3a.Only the amino acid 3b with the (2S,1'R)-configuration exhibits biological activity.