87319-89-9

Basic information

• Product Name: (R)-3-Hydroxy-hexanoic acid ((R)-2-hydroxy-1-phenyl-ethyl)-amide
• CAS NO: 87319-89-9
• Molecular Weight: 251.326
• Mol File: 87319-89-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-3-Hydroxy-hexanoic acid ((R)-2-hydroxy-1-phenyl-ethyl)-amide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-Hydroxy-hexanoic acid ((R)-2-hydroxy-1-phenyl-ethyl)-amide(87319-89-9)
• EPA Substance Registry System: (R)-3-Hydroxy-hexanoic acid ((R)-2-hydroxy-1-phenyl-ethyl)-amide(87319-89-9)

Safety Data

• Hazardous Substances Data: 87319-89-9(Hazardous Substances Data)

Upstream product

• 123-72-8 butyraldehyde 
• 875-74-1 (R)-phenylglycine 
• 56613-80-0 D-2-phenylglycinol 
• 78761-25-8 D-(-)-O,N-Diacetyl-α-phenylglycinol 

Relevant articles and documents

Stereoselective Aldol Reaction with Chiral Secondary Acetamides

The deprotonated acetamides 4a - c and 5a - c are added to prochiral carbonyl compounds.The influence of the solvent, of the reaction temperature, and of the enolate gegenion on the ratio of the isomeric products 8/9, 18/19, and 26/27, respectively, are studied.The highest degree of diastereoselectivity are observed, when the titanium enolate of the acetamide 4a or the threefold deprotonated N-acetyl-α-phenylglycinol (5a) is used.The diastereomers 18a - d, formed in excess in the addition of 5a to aldehydes, are isolated in pure from by a single recrystallization, and afford the enantiomerically pure β-hydroxy carboxylic acids 3a - d.Thereby, the chiral auxiliary, α-phenylglycinol (14), is recovered.