796967-48-1

Basic information

• Product Name: Urea, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-N'-[3-(trifluoro methyl)phenyl]-
• CAS NO: 796967-48-1
• Molecular Formula: C20H22BF3N2O3
• Molecular Weight: 406.212
• Mol File: 796967-48-1.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Urea, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-N'-[3-(trifluoro methyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Urea, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-N'-[3-(trifluoro methyl)phenyl]-(796967-48-1)
• EPA Substance Registry System: Urea, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-N'-[3-(trifluoro methyl)phenyl]-(796967-48-1)

Safety Data

• Hazardous Substances Data: 796967-48-1(Hazardous Substances Data)

Usage

General Description

The chemical "Urea, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-N'-[3-(trifluoromethyl)phenyl]-" is a complex organic compound that contains urea, boron, and various phenyl groups. It is composed of nitrogen, carbon, hydrogen, oxygen, fluorine, and boron atoms. This chemical has potential applications in pharmaceuticals, agrochemicals, and materials science due to its unique structure and properties. It may also have uses in organic synthesis and as a building block for the development of new compounds with specific properties. Its precise uses and effects would depend on further research and testing.

Upstream product

• 329-01-1 1-isocyanato-3-trifluoromethyl-benzene 
• 214360-73-3 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline 
• 98-16-8 3-trifluoromethylaniline 
• 106-40-1 4-bromo-aniline 
• 195452-46-1 1-(4-bromophenyl)-3-(3-(trifluoromethyl)phenyl)urea 
• 73183-34-3 bis(pinacol)diborane 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 80460-73-7 (4-aminophenyl)boronic acid hydrochloride 
• 76-09-5 2,3-dimethyl-2,3-butane diol 

Downstream Products

• 819058-32-7 C₂₁H₁₅F₃N₄OS 

Relevant articles and documents

Diaryl urea compounds with anti-tumor activity as well as preparation method and application of diaryl urea compounds

The invention provides diaryl urea compounds with anti-tumor activity as well as a preparation method and an application of the diaryl urea compounds. A structural formula of the compounds is shown in the specification, wherein R1 represents hydrogen, and R2 represents isopropyl or halogen groups. The compounds have good inhibition activity for VEGFR-2 (vascular endothelial growth factor-2) kinase, and can block VEGFR-2 kinase induced signaling pathways and inhibit tumor cell proliferation and migration by inhibiting activity of VEGFR-2 kinase, so that the compounds can be applied to preparation of anti-tumor drugs. Besides, the preparation method of the compounds has the advantages that raw materials are easily available, reaction conditions are mild, a reaction process is simple to operate and used reagents are cheap.

Discovery of novel anti-angiogenesis agents. Part 7: Multitarget inhibitors of VEGFR-2, TIE-2 and EphB4

Herein, we embarked on a structural optimization campaign aiming at the discovery of second generation anti-angiogenesis agents with our previously reported BPS-7 as lead compound. A library of 27 compounds has been afforded based on the highly conserved ATP-binding pocket of VEGFR-2, Tie-2, and EphB4. Several title compounds exhibited simultaneous inhibitory effects against three angiogenic RTKs. These compounds with a ‘triplet’ inhibition profile have been identified as novel anti-angiogenic and anticancer agents. The representative VDAU11 displayed prominent anti-angiogenic and anticancer potency and could be considered as a candidate for further optimization. These results indicate that N-(pyridin-2-yl)acrylamide could serve as a novel hinge-binding group of triple inhibitors.

COMBINED MODULATION OF IRE1

Described herein, inter alia, are combined compositions of an Irel kinase modulating compound and an Irel ribonuc lease modulating compound and methods of using same.