80-51-3

Basic information

• Product Name: 4,4'-Oxybis(benzenesulfonyl hydrazide)
• Synonyms: 4,4''-OXYDIBENZENESULFONYL HYDRAZIDE (OBSH);Foamer OBSH;4,4'-Bis(hydrazinosulfonyl)diphenyl ether;Neocellborn 1000SW;[Oxybis[(4,1-phenylene)sulfonyl]]bishydrazide;4,4'-Oxybis(benzenesulfonohydrazide);4,4'-Oxybis(hydrazinosulfonylbenzene);4,4'-Oxybisbenzenesulfonohydrazide
• CAS NO: 80-51-3
• Molecular Formula: C₁₂H₁₄N₄O₅S₂
• Molecular Weight: 358.39
• EINECS: 201-286-1
• Mol File: 80-51-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 160-161 °C (dec.)(lit.)
• Boiling Point: 590 °C at 760 mmHg
• Flash Point: 310.6 °C
• Appearance: White/Solid
• Density: 1.4940 (rough estimate)
• Vapor Pressure: 0.001Pa at 80℃
• Refractive Index: 1.6000 (estimate)
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
• PKA: 8.76±0.10(Predicted)
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: 4,4'-Oxybis(benzenesulfonyl hydrazide)(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-Oxybis(benzenesulfonyl hydrazide)(80-51-3)
• EPA Substance Registry System: 4,4'-Oxybis(benzenesulfonyl hydrazide)(80-51-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• RTECS: DB7321000
• TSCA: Yes
• HazardClass: 4.1
• Hazardous Substances Data: 80-51-3(Hazardous Substances Data)

Usage

Uses

4,4''-Oxydibenzenesulfonyl Hydrazide can be used for an antimicrobial mask with an anti-fog function.

General Description

A colorless, crystalline solid with a geranium-like odor. Insoluble in water and denser than water. Flash point 239°F. Boiling point 257°F. Contact may irritate skin, eyes and mucous membranes. Moderately toxic by ingestion, inhalation and skin absorption. Readily ignited by sparks or flames and burns intensely and persistently.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4,4'-Oxybis(benzenesulfonyl hydrazide) is an azide. Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides.

Flammability and Explosibility

Notclassified

Safety Profile

Mutation data reported. A flammable solid. When heated to decomposition it emits very toxic fumes of NOx and SOx

Synthetic route

4,4'-bis(sulfonic acid)diphenyl ether (3232-24-4) → diphenylether-4,4'-disulfonyl hydrazide (80-51-3)

Conditions	Yield
With carbazic acid In neat (no solvent) at 100℃; for 5h; Reagent/catalyst; Green chemistry;	97%

4,4'-oxybis(benzenesulfonyl chloride) (121-63-1) → diphenylether-4,4'-disulfonyl hydrazide (80-51-3)

Conditions	Yield
With carbazic acid In neat (no solvent) at 100℃; for 5h; Reagent/catalyst; Temperature; Solvent; Green chemistry;	91%
With hydrazine
With hydrazine hydrate

diphenylether-4,4'-disulfonyl hydrazide (80-51-3) → 4,4′-disulfonylazidophenyl ether

Conditions	Yield
With hydrogenchloride; sodium nitrite In methanol; water at 0℃; Temperature; Solvent;	96%
With acetic acid; sodium nitrite

diphenylether-4,4'-disulfonyl hydrazide (80-51-3) + phenylacetylene (536-74-3) → (E)-1,1'-((2,2'-iodo-2-phenylvinyl)-4,4'-oxybis(benzenesulfonyl)vinyl)benzene

Conditions	Yield
With sodium iodide In chloroform; water at 20℃; for 5h; Electrolysis; stereoselective reaction;	75%

1-ethoxy-4,5-dihydro-3H-benzo[4,5]thieno[2,3-c]azepine (50491-70-8) + diphenylether-4,4'-disulfonyl hydrazide (80-51-3) → 4,4'-oxy-bis-benzenesulfonic acid bis-[(2,3,4,5-tetrahydro-benzo[4,5]thieno[2,3-c]azepin-1-ylidene)-hydrazide] (50491-76-4)

Conditions	Yield
In ethanol for 22h; Heating;

Upstream product

• 3232-24-4 4,4'-bis(sulfonic acid)diphenyl ether 
• 121-63-1 4,4'-oxybis(benzenesulfonyl chloride) 

Relevant articles and documents

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