81338-23-0

Basic information

• Product Name: D-AP7
• Synonyms: D-(-)-2-AMINO-7-PHOSPHONOHEPTANOIC ACID;D-(-)-AP-7;D-AP7;D(-)-2-AMINO-7-PHOSPHONOHEPTANOIC ACID S ELECTIVE NMDA ANTAGO;(2R)-2-Amino-7-phosphonoheptanoic acid;(R)-2-Amino-7-phosphonoheptanoic acid;(R)-AP-7;[R,(-)]-2-Amino-7-phosphonoheptanoic acid
• CAS NO: 81338-23-0
• Molecular Formula: C7H16NO5P
• Molecular Weight: 225.18
• Product Categories: Glutamate receptor
• Mol File: 81338-23-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 480.1 °C at 760 mmHg
• Flash Point: 244.2 °C
• Appearance: /
• Density: 1.39 g/cm³
• Vapor Pressure: 1.54E-10mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: Store at RT
• PKA: 2.54±0.24(Predicted)
• CAS DataBase Reference: D-AP7(CAS DataBase Reference)
• NIST Chemistry Reference: D-AP7(81338-23-0)
• EPA Substance Registry System: D-AP7(81338-23-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 81338-23-0(Hazardous Substances Data)

Usage

Uses

D-AP7 is 8-Bromo-cGMP.

Biological Activity

More active form of AP7.

InChI:InChI=1/C7H16NO5P/c8-6(7(9)10)4-2-1-3-5-14(11,12)13/h6H,1-5,8H2,(H,9,10)(H2,11,12,13)/t6-/m1/s1

Upstream product

• 85797-13-3 AP-7 
• 258278-52-3 2-(N-phenylacetylamino)-7-phosphonoheptanoic acid 
• 42757-42-6 diethyl 5-bromopentanephosphonate 
• 5183-26-6 diethyl acetamido(5-bromopentyl)malonate 
• 111-24-0 1,5-dibromo-pentane 
• 137622-48-1 2-Acetylamino-2-(5-phosphono-pentyl)-malonic acid diethyl ester 
• 137622-51-6 2-Acetylamino-2-[5-(dimethoxy-phosphoryl)-pentyl]-malonic acid diethyl ester 
• 85685-91-2 (N-acetylamino-6 bis-ethoxycarbonyl-6,6)-hexylphosphonate de diethyle 

Downstream Products

• 81338-23-0 D-2-amino-7-phosphonoheptanoate 
• 81338-23-0 2-amino-7-phosphono-heptanoic acid 

Relevant articles and documents

Involucrin gene expression promoter

PROBLEM TO BE SOLVED: To provide an involucrin gene expression promoter that has high effect of promoting involucrin gene expression, and is applied to the skin, to quickly increase involucrin concentrations, and markedly improving the barrier function. SOLUTION: An involucrin gene expression promoter contains at least one selected from a compound represented by the following formula (1) [where R1 and R2 are the same or different to represent a hydrogen atom, or a substituent. n is an integer of 1 or greater], a salt thereof, and their hydrates as an active ingredient. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPO&INPIT

Phosphorus-containing aminocarboxylic acids. VII. Asymmetric synthesis of ω-phosphono-α-aminocarboxylic acids

New asymmetric ω-phosphono-α-aminocarboxylic acids were synthesized by alkylation with ω-bromoalkylphosphonates of the glycine methylene group in the Ni(II) complex of the Schiff base derived from glycine and (S)- and (R)-2-N-(N-benzylprolyl)-o-aminobenzo

SYNTHESE D'ACIDES ω-AMINO-ω-CARBOXY-ALKYLPHOSPHONIQUES

ω-Amino ω-carboxyalkylphosphonic acids 1 synthesis is reviewed.For n = 4, 5, 6 a general, efficient and inexpensive synthesis is described; acetamido(ω-bromoalkyl)malonates 12 are prepared from commercial dibromoalkanes and acetamidomalonate using the phase transfer catalysis process, then condensed with triethylphosphite through an Arbuzov reaction.An acid hydrolysis followed by purification on Dowex gives aminophosphonic acids 1 (n = 4, 5, 6) with a 70percent overall yield.The lower acid 1 (n = 2) is obtained with an identical overall yield from acetamidomalonate and 2-haloethylphosphonate using also liquid-solid phase transfer catalysis.