815610-16-3 Usage
General Description
4-Iodopyrimidin-2-amine, also known as 2-amino-4-iodopyrimidine, is a chemical compound with the molecular formula C4H4IN3. It is a halogenated derivative of pyrimidine and contains an amino group. 4-Iodopyrimidin-2-amine is commonly used in the synthesis of pharmaceuticals and is used as a building block in the preparation of various bioactive molecules. Its combination of an amine and iodine group make it a versatile intermediate for organic synthesis, allowing for the creation of a wide range of novel compounds for medicinal and scientific research.
Check Digit Verification of cas no
The CAS Registry Mumber 815610-16-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,1,5,6,1 and 0 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 815610-16:
(8*8)+(7*1)+(6*5)+(5*6)+(4*1)+(3*0)+(2*1)+(1*6)=143
143 % 10 = 3
So 815610-16-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H4IN3/c5-3-1-2-7-4(6)8-3/h1-2H,(H2,6,7,8)
815610-16-3Relevant articles and documents
Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors
Reichelt, Andreas,Bailis, Julie M.,Bartberger, Michael D.,Yao, Guomin,Shu, Hong,Kaller, Matthew R.,Allen, John G.,Weidner, Margaret F.,Keegan, Kathleen S.,Dao, Jennifer H.
, p. 364 - 382 (2014/05/20)
The Cell division cycle 7 (Cdc7) protein kinase is essential for DNA replication and maintenance of genome stability. We systematically explored thiazole-based compounds as inhibitors of Cdc7 kinase activity in cancer cells. Our studies resulted in the identification of a potent, selective Cdc7 inhibitor that decreased phosphorylation of the direct substrate MCM2 in vitro and in vivo, and inhibited DNA synthesis and cell viability in vitro.
