815645-30-8Relevant articles and documents
(S,S)-trans-cyclopentane-constrained peptide nucleic acids. A general backbone modification that improves binding affinity and sequence specificity
Pokorski, Jonathan K.,Witschi, Mark A.,Purnell, Bethany L.,Appella, Daniel H.
, p. 15067 - 15073 (2007/10/03)
Replacing the ethylenediamine portion of aminoethylglycine peptide nucleic acids (aegPNAs) with one or more (S,S)-trans-cyclopentane diamine units significantly increases binding affinity and sequence specificity to complementary DNA, making these modifie