82027-51-8Relevant articles and documents
Compact reaction-module on a pad for scalable flow-production of organophosphates as drug scaffolds
Kang, In Seok,Kim, Dong-Pyo,Ramanjaneyulu, Bandaru T.,Vidyacharan, Shinde,Yang, Yu Dong,Yim, Se Jun
, p. 973 - 978 (2020/03/13)
Continuous pharmaceutical manufacturing receives intense attention as an alternative way to meet flexible market needs with the assurance of higher safety and quality control. Here, we report a compact reaction-module on a pad (CRP, 170 × 170 × 1.2 mm) for scale-up production of drug precursors in a continuous-flow. The CRP system was devised by stacking 9 films of the patterned polyimide to integrate micro-flow circuits, combining the functions of the even distribution of feeds, being completely mixed in less than a few milliseconds. A methodology of using a highly reactive species for the single-step synthesis of α-phosphonyloxy ketone, a drug scaffold, required the synthesis time of a few seconds in microfluidics. The fast reaction in the single CRP was capable of producing 19.2 g h-1 drug precursor, which indicates a solid step toward kilogram-scale pharmaceutical manufacturing in small footage.
Preparation of alkyl formates from corresponding alcohols using ethyl formate catalyzed by poly(4-vinylpyridinium tribromide) under neutral and solvent-free conditions
Ghorbani-Choghamarani, Arash,Norouzi, Masoomeh
experimental part, p. 1399 - 1402 (2011/12/15)
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Ceric ammonium nitrate promoted oxidation of oxazoles
Evans, David A.,Nagorny, Pavel,Xu, Risheng
, p. 5669 - 5671 (2007/10/03)
The ceric ammonium nitrate promoted oxidations of 4,5-diphenyloxazoles and oxazoles with various substitution patterns have been investigated. This transformation results in the formation of the corresponding imide in good yield and tolerates a wide variety of functional groups and substituents on the oxazole moiety.
