82130-75-4

Basic information

• Product Name: 2(3H)-Furanone, dihydro-4-(phenylmethoxy)-, (4S)-
• CAS NO: 82130-75-4
• Molecular Formula: C11H12O3
• Molecular Weight: 192.214
• Mol File: 82130-75-4.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 2(3H)-Furanone, dihydro-4-(phenylmethoxy)-, (4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(3H)-Furanone, dihydro-4-(phenylmethoxy)-, (4S)-(82130-75-4)
• EPA Substance Registry System: 2(3H)-Furanone, dihydro-4-(phenylmethoxy)-, (4S)-(82130-75-4)

Safety Data

• Hazardous Substances Data: 82130-75-4(Hazardous Substances Data)

Upstream product

• 81927-55-1 O-benzyl 2,2,2-trichloroacetimidate 
• 5469-16-9 (3S)-hydroxy-γ-butyrolactone 
• 100-39-0 benzyl bromide 
• 201230-82-2 carbon monoxide 
• 95257-22-0 3-(benzyloxy)oxetane 
• 30830-27-4 3-benzyloxy cyclobutanone 
• 5469-16-9 4-Hydroxy-dihydro-furan-2-on 
• 86185-81-1 2-(benzyloxy)-1,4-butanediol 
• 75322-91-7 3-Benzyloxy-dihydro-furan-2,5-dione 
• 1031428-76-8 3-(benzyloxy)-4-chlorobutanenitrile 
• 129611-57-0 (2S,4S,5R)-4-Methyl-5-phenyl-3-carbobenzyloxy-2-<(1S)-1-benzyloxy-2-carbobenzyloxy>ethyloxazolidine 
• 129611-58-1 2-<(1S)-1-Benzyloxy-2-carbobenzyloxy>-ethyl-1,3-dithiolane 
• 129611-53-6 Benzyl (3S)-3-benzyloxy-4-oxobutanoate 
• 82130-73-2 dimethyl (S)-(-)-2-benzyloxybutanedioate 

Downstream Products

• 713519-32-5 (S)-3-benzyloxy-N,O-dimethyl-4-hydroxybutyramide 
• 259877-36-6 4-(benzyloxy)tetrahydrofuran-2-yl acetate 
• 1379457-31-4 C₂₃H₂₄FN₅O₅ 
• 1379457-32-5 C₂₃H₂₂FN₅O₄ 
• 1379457-26-7 N-(4-((S)-5-(acetamidomethyl)-2-oxo-oxazolidin-3-yl)-2-fluorophenyl)-3-(benzyloxy)-4-hydroxybutanamide 
• 911313-90-1 (3S)-N(H)-3-(benzyloxy)pyrrolidine 
• 1374255-90-9 (S)-2-benzyloxy-4-(2,2,2-trifluoroacetamido)butyl methanesulfonate 
• 1374255-89-6 (S)-N-[3-(benzyloxy)-4-hydroxybutyl]-2,2,2-trifluoroacetamide 
• 1374255-88-5 (S)-4-amino-2-(benzyloxy)butan-1-ol 
• 186429-14-1 (S)-3-benzyloxy-4-hydroxybutanamide 
• 82130-83-4 2-((E)-(S)-2-Benzyloxy-4-chloro-but-3-enyl)-5,5-dimethyl-[1,3]dioxane 
• 82130-80-1 Toluene-4-sulfonic acid (S)-2-benzyloxy-3-(5,5-dimethyl-[1,3]dioxan-2-yl)-propyl ester 
• 82130-82-3 2-((S)-4-Benzenesulfinyl-2-benzyloxy-4-chloro-butyl)-5,5-dimethyl-[1,3]dioxane 
• 82130-85-6 2-((S)-2-Benzyloxy-but-3-ynyl)-5,5-dimethyl-[1,3]dioxane 

Relevant articles and documents

Efficient Synthesis of γ-Lactones by Cobalt-Catalyzed Carbonylative Ring Expansion of Oxetanes under Syngas Atmosphere

A practical route from oxetane or thietane to γ-(thio)butyrolactone via solvated-proton-assisted cobalt-catalyzed carbonylative ring expansion under syngas atmosphere has been established. A wide variety of γ-(thio)butyrolactones can be afforded in good to excellent yields. The versatility of this method has been well demonstrated in the synthesis of intermediates towards the natural product Arctigenin as well as the pharmaceuticals Baclofen and Montelukast. The observed promoting effect of glycol ether solvent has been rationally interpreted.

Flavinium and Alkali-Metal Assembly on Sulfated Chitin: A Heterogeneous Supramolecular Catalyst for H2O2-Mediated Oxidation

Heterogeneous multiple-catalyst assemblies were developed in which the flavinium cation and Na or Li cations were easily immobilized on a chitin-derived anionic polymeric scaffold through noncovalent ionic interactions. The supramolecular flavinium catalysts were successfully employed in the environmentally friendly heterogeneous Baeyer–Villiger oxidation and sulfoxidation by H2O2. Owing to the cooperative catalytic effect of flavinium, alkali metal, and sulfated chitin, the supramolecular flavinium assembly showed higher catalytic activity for the Baeyer–Villiger oxidation of cyclic ketones than the corresponding homogeneous flavinium catalyst. Because the ionic assembly was stable under the reaction conditions, the catalyst could be readily recovered by simple filtration and reused.

Lactonization reactions through hydrolase-catalyzed peracid formation. Use of lipases for chemoenzymatic Baeyer-Villiger oxidations of cyclobutanones

A one-pot chemoenzymatic method has been described for the synthesis of γ-butyrolactones starting from the corresponding ketones through a Baeyer-Villiger reaction. The approach is based on a lipase-catalyzed perhydrolysis for the formation of peracetic acid, which is the responsible for the ketone oxidation. Optimization studies have been performed in the oxidation of cyclobutanone, finding Candida antarctica lipase type B, ethyl acetate and urea-hydrogen peroxide complex as the best system. The relative ratio of these reagents has also been analyzed in depth. This synthetic approach has been successfully extended to a family of 3-substituted cyclobutanones in high substrate concentration, yielding the corresponding lactones with excellent isolated yields and purities, under mild reaction conditions and after a simple extraction protocol.