82240-03-7

Basic information

• Product Name: 4-[P-(BENZYLOXY)PHENYL]CYCLOHEXANONE
• Synonyms: 4-(4'-BENZYLOXY-PHENYL)-CYCLOHEXANONE;4-[P-(BENZYLOXY)PHENYL]CYCLOHEXANONE
• CAS NO: 82240-03-7
• Molecular Formula: C₁₉H₂₀O₂
• Molecular Weight: 280.36
• Mol File: 82240-03-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-[P-(BENZYLOXY)PHENYL]CYCLOHEXANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[P-(BENZYLOXY)PHENYL]CYCLOHEXANONE(82240-03-7)
• EPA Substance Registry System: 4-[P-(BENZYLOXY)PHENYL]CYCLOHEXANONE(82240-03-7)

Safety Data

• Hazardous Substances Data: 82240-03-7(Hazardous Substances Data)

Upstream product

• 16715-88-1 4-(4-hydroxyphenyl)cyclohexanol 
• 92-88-6 4,4'-Dihydroxybiphenyl 
• 105640-07-1 4-(4-hydroxyphenyl)cyclohexan-1-one 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 

Downstream Products

• 82240-04-8 α-<1-idrossi-4-(4-benzilossifenil)cicloesil>butirrato d'etile 
• 105640-07-1 4-(4-hydroxyphenyl)cyclohexan-1-one 
• 865458-75-9 1-[4-(4-benzyloxyphenyl)-cyclohex-1-enyl]-pyrrolidine 
• 103212-34-6 trans-1-(4-benzyloxy-phenyl)-4-(toluene-4-sulfonyloxy)-cyclohexane 
• 82240-05-9 acido α-<1-idrossi-4-(4-benzilossifenil)cicloesil>butirrico 
• 82205-94-5 acido α-<1-idrossi-4-(4-idrossifenil)cicloesil>butirrico 
• 860616-51-9 6-[4-(3-bromo-propoxy)-3-chloro-phenyl]-spiro[2.5]octane 
• 860616-71-3 6-(4-benzyloxy-phenyl)-spiro[2.5]octane 
• 102162-14-1 (1r,4r)-4-(4-(benzyloxy)phenyl)cyclohexan-1-ol 
• 1402465-93-3 methyl 6-(4-hydroxyphenyl)spiro[2.5]octane-1-carboxylate 
• 1402465-92-2 methyl 6-(4-(benzyloxy)phenyl)spiro[2.5]octane-1-carboxylate 
• 1402465-91-1 methyl 2-(4-(4-(benzyloxy)phenyl)cyclohexylidene)acetate 
• 259664-11-4 trans 4-(4-benzyloxy-phenyl)-cyclohexyl-amine 
• 149507-41-5 4-((1r,4r)-4-aminocyclohexyl)phenol 

Relevant articles and documents

Metal-Free C-O Bond Functionalization: Catalytic Intramolecular and Intermolecular Benzylation of Arenes

A catalytic, metal-free intramolecular rearrangement of benzyl phenyl ethers using nitrosonium salt as a catalyst is described. The optimized reaction conditions enabled a catalytic and metal-free Friedel-Crafts alkylation reaction with benzylic alcohols, producing water as the stoichiometric byproduct. A comprehensive scope (>50 examples) for both approaches and application in drug synthesis were demonstrated. Mechanistic studies suggest a Lewis acid-based mechanism for the metal-free Friedel-Crafts reaction.

Method for synthesizing 4-(4-hydroxyphenyl) cyclohexanone

The invention belongs to the technical field of electronic material intermediate, and discloses a method for synthesizing 4-(4-hydroxyphenyl) cyclohexanone. The method comprises the following steps: reducing 4,4'-diphenol with Al-Ni to prepare 4-(4-cyclohexanamide)-phenol; then preparing 4-(4-benzyloxy-benzene) cyclohexanol with benzyl chloride protection; oxidizing with chromium trioxide to obtain 4-(4-benzyloxy-benzene) cyclohexanone; and finally hydrogenating with 5% Pd/C to obtain 4-(4-hydroxyphenyl) cyclohexanone having a molecular formula of C12H14O2. The 4-(4-hydroxyphenyl) cyclohexanone prepared by the method is an electronic material and medicinal intermediate; and the synthesizing method has the advantages of reasonable process design, high yield and short production cycle, is economical and feasible, and easily realizes industrial production.

INHIBITORS OF DIACYLGLYCEROL O-ACYLOTRANSFERASE TYPE 1 ENZYME

Compounds of formula (I), or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof. Pharmaceutical compositions of formula (I) and related methods for treating or preventing metabolic diseases or conditions.