827628-31-9

Basic information

• Product Name: Carbamic acid, [1-(4-bromo-2-fluorophenyl)cyclopropyl]-, 1,1-dimethylethyl ester
• CAS NO: 827628-31-9
• Molecular Formula: C14H17BrFNO2
• Molecular Weight: 330.197
• Mol File: 827628-31-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [1-(4-bromo-2-fluorophenyl)cyclopropyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [1-(4-bromo-2-fluorophenyl)cyclopropyl]-, 1,1-dimethylethyl ester(827628-31-9)
• EPA Substance Registry System: Carbamic acid, [1-(4-bromo-2-fluorophenyl)cyclopropyl]-, 1,1-dimethylethyl ester(827628-31-9)

Safety Data

• Hazardous Substances Data: 827628-31-9(Hazardous Substances Data)

Upstream product

• 872422-15-6 1-(4-bromo-2-fluorophenyl)cyclopropane-1-carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 105942-08-3 4-bromo-6-fluorobenzonitrile 

Relevant articles and documents

N-METHYL, N-(6-(METHOXY)PYRIDAZIN-3-YL) AMINE DERIVATIVES AS AUTOTAXIN (ATX) MODULATORS FOR THE TREATMENT OF INFLAMMATORY AIRWAY OR FIBROTIC DISEASES

The present invention relates to N-methyl, N-(6-(methoxy)pyridazin-3- yl) amine derivatives as autotaxin (ATX) modulators for the treatment of inflammatory airway or fibrotic diseases such as e.g. idiopathic lung disease (IFF) or systemic sclerosis (SSc). The present description discloses the preparation of exemplary compounds (e.g. pages 37 to 45; examples 1.1 to 1.13) as well as relevant biological data thereof (e.g. pages 12 to 17, tables 1 to 9). An exemplary compound is e.g. l-[4-(4-{l-[(6-{[6-(trifluoromethyl) pyridin-3-yl]methoxy}pyridazin-3-yl)amino]cyclopropyl}-phenyl) piperazin-l-yl]ethan-l-one (example 1.1).

HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF

The present invention relates to imidazo pyridine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.