82935-42-0

Basic information

• Product Name: REMOXIPRIDE
• CAS NO: 82935-42-0
• Molecular Weight: 0
• Mol File: 82935-42-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: REMOXIPRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: REMOXIPRIDE(82935-42-0)
• EPA Substance Registry System: REMOXIPRIDE(82935-42-0)

Safety Data

• Hazardous Substances Data: 82935-42-0(Hazardous Substances Data)

Usage

Description

Remoxipride hydrochloride is a new selective dopamine D2-antagonist for the treatment of schizophrenia and other psychoses where thought disorders are prominent symptoms. Efficacy appears to be similar to that of haloperidol, with reportedly significantly less extrapyramidal side-effects.

Brand name

Roxiam

Upstream product

• 26116-12-1 1-ethyl-2-pyrrolidinemethanamine 
• 84225-91-2 5-bromo-2,6-dimethoxybenzoic acid chloride 
• 73219-89-3 3-bromo-2,6-dimethoxybenzoic acid 
• 1466-76-8 2-6-dimethoxybenzoic acid 
• 113310-91-1 di-L-(+)-tartrate salt of (S)-2-aminomethyl-1-ethylpyrrolidine 
• 22795-99-9 (S)-2-(Aminomethyl)-1-ethylpyrrolidine 
• 84277-13-4 di-D-(-)-tartrate salt of (S)-2-aminomethyl-1-ethylpyrrolidine 

Relevant articles and documents

3-Aminomethylbiphenyls. A New Class of Dopamine Receptor Ligands

A series of 3-aminomethylbiphenyls were prepared in three steps from 3-phenylbenzoic acid and their affinities for the D2, D3 and D4 dopamine receptor subtypes determined. Most of the compounds described contained unique amine subunits of known dopaminergic agents. The compounds containing the amino tails present in the antipsychotic drugs haloperidol, pimozide and miliperidine displayed selectivity for the D2 receptor. Five-fold selectivity for the D4 receptor was observed in the compound 1-(3-biphenyl)-4-(2-pyrimidyl)piperazine. This selectivity for D4 vs. D2 receptors is comparable to that observed with the atypical antipsychotic clozapine.