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83-49-8

83-49-8

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83-49-8 Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 83-49-8 differently. You can refer to the following data:
1. Protected β-Hyodeoxycholic Acid (H998105), a potential bile acid metabolite.
2. Labelled Hyodeoxycholic Acid. Unlabelled version is isolated from pig bile. Antitumor agent
3. It is isolated from pig bile. Antitumor agent
4. Labelled β-Hyodeoxycholic Acid

Definition

ChEBI: A member of the class of 5beta-cholanic acids that is (5beta)-cholan-24-oic acid substituted by alpha-hydroxy groups at positions 3 and 6.

General Description

Hyodeoxycholic acid is a naturally occurring secondary bile acid. It is produced by the gut flora in the small intestine. Hyodeoxycholic acid is obtained from chenodeoxycholic acid during enterohepatic circulation of bile in rats.

Purification Methods

Crystallise -hyodeoxycholic acid from EtOAc or Me2CO. The K salt separates in needles from an alcoholic solution of the acid when an equivalent of KOMe is added (see lithocholic acid). [Weiland & Gumlish Hoppe Seyler's Z Physiol Chem 215 18 1933, Windaus & Bohne Justus Liebigs Ann Chem 433 278 1923, Beilstein 10 III 1631.]

Check Digit Verification of cas no

The CAS Registry Mumber 83-49-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 3 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 83-49:
(4*8)+(3*3)+(2*4)+(1*9)=58
58 % 10 = 8
So 83-49-8 is a valid CAS Registry Number.
InChI:InChI=1/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15-,16+,17-,18+,19+,20+,21+,23-,24-/m1/s1

83-49-8 Well-known Company Product Price

  • Brand
  • (Code)Product description
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  • Alfa Aesar

  • (B20506)  Hyodeoxycholic acid, 96%   

  • 83-49-8

  • 5g

  • 548.0CNY

  • Detail

  • Alfa Aesar

  • (B20506)  Hyodeoxycholic acid, 96%   

  • 83-49-8

  • 25g

  • 1760.0CNY

  • Detail

  • Alfa Aesar

  • (B20506)  Hyodeoxycholic acid, 96%   

  • 83-49-8

  • 100g

  • 6236.0CNY

  • Detail

  • Sigma

  • (H3878)  Hyodeoxycholicacid  ≥98%

  • 83-49-8

  • H3878-5G

  • 833.04CNY

  • Detail

83-49-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name hyodeoxycholic acid

1.2 Other means of identification

Product number -
Other names Hyodeoxycholic

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:83-49-8 SDS

83-49-8Relevant articles and documents

PROCESS FOR THE PREPARATION OF CHOLANIC ACIDS

-

Page/Page column 2, (2008/06/13)

A process for the preparation of high purity cholanic acids, typically in purity equal to or higher than 99%.

Xanthomonas maltophilia CBS 897.97 as a source of new 7β- and 7α-hydroxysteroid dehydrogenases and cholylglycine hydrolase: Improved biotransformations of bile acids

Pedrini, Paola,Andreotti, Elisa,Guerrini, Alessandra,Dean, Mariangela,Fantin, Giancarlo,Giovannini, Pier Paolo

, p. 189 - 198 (2007/10/03)

The paper reports the partial purification and characterization of the 7β- and 7α-hydroxysteroid dehydrogenases (HSDH) and cholylglycine hydrolase (CGH), isolated from Xanthomonas maltophilia CBS 897.97. The activity of 7β-HSDH and 7α-HSDH in the reduction of the 7-keto bile acids is determined. The affinity of 7β-HSDH for bile acids is confirmed by the reduction, on analytical scale, to the corresponding 7β-OH derivatives. A crude mixture of 7α- and 7β-HSDH, in soluble or immobilized form, is employed in the synthesis, on preparative scale, of ursocholic and ursodeoxycholic acids starting from the corresponding 7α-derivatives. On the other hand, a partially purified 7β-HSDH in a double enzyme system, where the couple formate/formate dehydrogenase allows the cofactor recycle, affords 6α-fluoro-3α, 7β-dihydroxy-5β-cholan-24-oic acid (6-FUDCA) by reduction of the corresponding 7-keto derivative. This compound is not obtainable by microbiological route. The efficient and mild hydrolysis of glycinates and taurinates of bile acids with CGH is also reported. Very promising results are also obtained with bile acid containing raw materials.

Progesterone from 3-alpha-hydroxy-6-oxo-5-alpha-cholic acid

Lehmann,Tepper,Hilgetag

, p. 176 - 181 (2007/10/06)

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