84029-94-7Relevant articles and documents
TARGET PROTEIN EED DEGRADATION-INDUCING DEGRADUCER, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATED TO EED, EZH2, OR PRC2, COMPRISING SAME AS ACTIVE INGREDIENT
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, (2021/12/23)
The present invention relates to a target protein degradation-inducing Degraducer, a preparation method thereof, and a pharmaceutical composition for preventing or treating diseases related to EED, EZH2, or PRC2 comprising same as an active ingredient. A novel compound represented by formula 1, according to the present invention is a Degraducer compound that induces degradation of a target protein, i.e., embryonic ectoderm development (EED) or polycomb repressive complex 2 (PRC2), utilizing cereblon E3 ubiquitin ligase, von Hippel-Lindau tumor suppressor (VHL) E3 ubiquitin ligase, mouse double minute 2 homolog (MDM2) E3 ubiquitin ligase, and cellular inhibitor of apoptosis protein 1 (cIAP) E3 ubiquitin ligase, wherein the compound has an aspect of remarkably achieving target protein degradation-inducing activity through a ubiquitin proteasome system (UPS), and therefore there is a useful effect in that it is possible to provide a pharmaceutical composition for preventing or treating diseases or conditions related to a target protein, and a functional health food composition for preventing or improving same, comprising said compound as an active ingredient.
Method of Preparing Aminoundecane Acid and 11-Aminoundecanoic Acid or Structural Isomer Thereof by Hydroformylation Reaction
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Paragraph 0112-0116; 0119-0136, (2020/11/03)
The present invention relates to a method for preparing 11-aminoundecanoic acid or structural isomers thereof using a hydroformylation reaction. More particularly, the present invention is an eco-friendly method capable of preparing aminoundecanoic acid used as a monomer of polyamide and structural isomers thereof from an olefinic acid ester obtained through a metathesis reaction of oleic acid by means of hydroformylation, reductive amination reaction, and hydrolysis reaction, and capable of producing various polyamides having different physical properties according to a ratio of each isomer since the ratio of structural isomers can be adjusted according to a ligand.COPYRIGHT KIPO 2021
Preparation method of 11-aminoundecanoic acid
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, (2019/04/27)
The invention provides a preparation method of 11-aminoundecanoic acid. The method comprises the following steps: 1) dissolving 9-hydroxyl pelargonic acid or 9-hydroxyl pelargonate in a solvent and carrying out selective oxidization in the presence of an oxidant to prepare 9-oxo pelargonic acid or 9-oxo pelargonate; 2) dissolving 9-oxo pelargonic acid or 9-oxo pelargonate and cyanoacetate in a solvent for knoevenagel condensation reaction to obtain a compound as shown in a formula III; 3) continuously carrying out a hydrolysis reaction on the product obtained in the step 2) and carrying out acidification to obtain 2-cyano cyanohendecene-2-diacid; 4) carrying out a selective decarboxylic reaction on the product obtained in the step 3) to obtain a compound as shown in a formula V: 10-cyno-10-ene capric acid; and 5) adding a catalyst into the 10-cyno-10-ene capric acid obtained in the step 4), replacing the mixture with nitrogen and hydrogen successively for a hydrogenation reduction reaction, and refining a coarse product to obtain the 11-aminoundecanoic acid.
