84459-33-6

Basic information

• Product Name: 2-Bromo-5-chlorobenzaldehyde
• Synonyms: 4-chloro-2-broMobenzaldehyde;2-BroMo-4-chlorobenaldehyde;2-BroMo-4-chlorobenaldehy...;Benzaldehyde,2-broMo-4-chloro-;2 - broMine - 4 - chlorobenzene forMaldehyde
• CAS NO: 84459-33-6
• Molecular Formula: C₇H₄BrClO
• Molecular Weight: 219.47
• Mol File: 84459-33-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 69.0 to 73.0 °C
• Boiling Point: 264.6 °C at 760 mmHg
• Flash Point: 113.8 °C
• Appearance: /
• Density: 1.698 g/cm³
• Vapor Pressure: 0.0096mmHg at 25°C
• Refractive Index: 1.623
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-Bromo-5-chlorobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-chlorobenzaldehyde(84459-33-6)
• EPA Substance Registry System: 2-Bromo-5-chlorobenzaldehyde(84459-33-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 84459-33-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H4BrClO/c8-7-3-6(9)2-1-5(7)4-10/h1-4H

Upstream product

• 143888-84-0 (2-bromo-4-chloro-phenyl)methanol 
• 7745-91-7 3-bromo-4-methylaniline 
• 7745-93-9 2-bromo-4-nitrotoluene 
• 99-99-0 1-methyl-4-nitrobenzene 
• 936-08-3 2-bromo-4-chlorobenzoic acid 
• 1202889-66-4 2-bromo-4-chloro-1-(dibromomethyl)benzene 
• 27139-97-5 2-bromo-4-chloro-1-methyl-benzene 
• 57381-49-4 2-bromo-4-chloro-benzonitrile 
• 623-03-0 4-Cyanochlorobenzene 

Downstream Products

• 90987-56-7 8-Chloro-10-(3,4-dimethyl-phenyl)-3-phenyl-10H-pyrimido[4,5-b]quinoline-2,4-dione 
• 90987-50-1 8-Chloro-10-(4-chloro-phenyl)-3-methyl-10H-pyrimido[4,5-b]quinoline-2,4-dione 
• 685534-52-5 methyl (2E)-3-(2-bromo-4-chlorophenyl)acryIate 
• 1202889-67-5 2-bromo-4-chloro-1-[2-nitroethenyl]benzene 
• 143888-84-0 (2-bromo-4-chloro-phenyl)methanol 
• 1313762-44-5 2-vinyl-5-chlorobenzaldehyde 
• 1309453-77-7 4,4'-[(1Z,1Z')-2,2'-(2,5-dibromo-1,4-phenylene)bis(ethene-2,1-diyl)]bis(3-bromo-1-chlorobenzene) 
• 1278522-61-4 C₁₄H₈(C₆H₅)2BC₆H₂(CH₃)3 
• 1278522-53-4 C₅₂H₄₂N₂Si 
• 1278522-51-2 C₃₀H₂₈O₂Si 
• 1278522-49-8 C₁₄H₈(C₆H₅)2Si(CH₃)2 
• 1086599-39-4 2-(2-bromo-4-chlorophenyl)-2-fluoroacetonitrile 

Relevant articles and documents

Preparation method of 2 -bromo -4-chlorobenzaldehyde

The invention relates to a preparation method of 2 -bromo -4-chlorobenzaldehyde and belongs to the field of medicinal chemistry. The preparation method can obtain 2 -bromo -4-chlorobenzaldehyde by taking nitrotoluene as a starting material through substitution, reduction, substitution, substitution, substitution, hydrolysis and elimination reaction. Compared with the prior art, the method shortens the reaction time, the reaction temperature is higher 120 °C or higher, the reaction conditions are mild, the yield of the obtained product is about 70% and more than 90%. The reaction temperature is reduced, high-boiling-point solvent is not needed to participate in the reaction, the post-treatment is simple, and the method is more suitable for industrial production with strict safety and environmental protection.

FACTOR XIa INHIBITORS

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma Kallikrein.

NAPHTHYLACETIC ACIDS

The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.